An atlas of itch-associated neural dynamics in the mouse brain
Summary: The itch-scratching cycle is mediated by neural dynamics in the brain. However, our understanding of the neural dynamics during this cycle remains limited. In this study, we examine the neural dynamics of 126 mouse brain areas by measuring the calcium signal using fiber photometry. We prese...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-10-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723013165 |
| _version_ | 1827787582933565440 |
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| author | Wen-Zhen Chen Ting-Yu Shen Meng Wang Lin Yuan Lin-Han Wang Wen-Qun Ding Xiao-Xue Shi Xiao-Fei Wang Bin-Shi Bo Zhi-Feng Liang Yan-Gang Sun |
| author_facet | Wen-Zhen Chen Ting-Yu Shen Meng Wang Lin Yuan Lin-Han Wang Wen-Qun Ding Xiao-Xue Shi Xiao-Fei Wang Bin-Shi Bo Zhi-Feng Liang Yan-Gang Sun |
| author_sort | Wen-Zhen Chen |
| collection | DOAJ |
| description | Summary: The itch-scratching cycle is mediated by neural dynamics in the brain. However, our understanding of the neural dynamics during this cycle remains limited. In this study, we examine the neural dynamics of 126 mouse brain areas by measuring the calcium signal using fiber photometry. We present numerous response patterns in the mouse brain during the itch-scratching cycle. Interestingly, we find that a group of brain areas exhibit activation only at the end of histamine-induced scratching behavior. Additionally, several brain areas exhibit transient activation at the onset of scratching induced by chloroquine. Both histamine- and chloroquine-induced itch evoke diverse response patterns across the mouse brain. In summary, our study provides a comprehensive dataset for the diverse activity pattern of mouse brain during the itch-scratching cycle, paving the way for further exploration into the neural mechanisms underlying the itch-scratching cycle. |
| first_indexed | 2024-03-11T16:52:01Z |
| format | Article |
| id | doaj.art-05faad359b05408698da4c5da50d477c |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-11T16:52:01Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-05faad359b05408698da4c5da50d477c2023-10-21T04:22:33ZengElsevierCell Reports2211-12472023-10-014210113304An atlas of itch-associated neural dynamics in the mouse brainWen-Zhen Chen0Ting-Yu Shen1Meng Wang2Lin Yuan3Lin-Han Wang4Wen-Qun Ding5Xiao-Xue Shi6Xiao-Fei Wang7Bin-Shi Bo8Zhi-Feng Liang9Yan-Gang Sun10Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; University of Chinese Academy of Sciences, 19A Yu-quan Road, Beijing 100049, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; University of Chinese Academy of Sciences, 19A Yu-quan Road, Beijing 100049, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; University of Chinese Academy of Sciences, 19A Yu-quan Road, Beijing 100049, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Department of Orthopaedic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; University of Chinese Academy of Sciences, 19A Yu-quan Road, Beijing 100049, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; University of Chinese Academy of Sciences, 19A Yu-quan Road, Beijing 100049, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science & Intelligence Technology, Chinese Academy of Sciences, 320 Yue-Yang Road, Shanghai 200031, China; Corresponding authorSummary: The itch-scratching cycle is mediated by neural dynamics in the brain. However, our understanding of the neural dynamics during this cycle remains limited. In this study, we examine the neural dynamics of 126 mouse brain areas by measuring the calcium signal using fiber photometry. We present numerous response patterns in the mouse brain during the itch-scratching cycle. Interestingly, we find that a group of brain areas exhibit activation only at the end of histamine-induced scratching behavior. Additionally, several brain areas exhibit transient activation at the onset of scratching induced by chloroquine. Both histamine- and chloroquine-induced itch evoke diverse response patterns across the mouse brain. In summary, our study provides a comprehensive dataset for the diverse activity pattern of mouse brain during the itch-scratching cycle, paving the way for further exploration into the neural mechanisms underlying the itch-scratching cycle.http://www.sciencedirect.com/science/article/pii/S2211124723013165CP: Neuroscience |
| spellingShingle | Wen-Zhen Chen Ting-Yu Shen Meng Wang Lin Yuan Lin-Han Wang Wen-Qun Ding Xiao-Xue Shi Xiao-Fei Wang Bin-Shi Bo Zhi-Feng Liang Yan-Gang Sun An atlas of itch-associated neural dynamics in the mouse brain Cell Reports CP: Neuroscience |
| title | An atlas of itch-associated neural dynamics in the mouse brain |
| title_full | An atlas of itch-associated neural dynamics in the mouse brain |
| title_fullStr | An atlas of itch-associated neural dynamics in the mouse brain |
| title_full_unstemmed | An atlas of itch-associated neural dynamics in the mouse brain |
| title_short | An atlas of itch-associated neural dynamics in the mouse brain |
| title_sort | atlas of itch associated neural dynamics in the mouse brain |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723013165 |
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