Aberrant cerebellar connectivity in motor and association networks in schizophrenia
Schizophrenia is a devastating illness characterized by disturbances in multiple domains. The cerebellum is involved in both motor and non-motor functions, and the cognitive dysmetria and dysmetria of thought models propose that abnormalities of the cerebellum may contribute to schizophrenia signs a...
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Frontiers Media S.A.
2015-03-01
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Series: | Frontiers in Human Neuroscience |
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Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00134/full |
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author | Ann K. Shinn Ann K. Shinn Justin T. Baker Justin T. Baker Kathryn Eve Lewandowski Kathryn Eve Lewandowski Dost eOngur Dost eOngur Bruce M. Cohen Bruce M. Cohen |
author_facet | Ann K. Shinn Ann K. Shinn Justin T. Baker Justin T. Baker Kathryn Eve Lewandowski Kathryn Eve Lewandowski Dost eOngur Dost eOngur Bruce M. Cohen Bruce M. Cohen |
author_sort | Ann K. Shinn |
collection | DOAJ |
description | Schizophrenia is a devastating illness characterized by disturbances in multiple domains. The cerebellum is involved in both motor and non-motor functions, and the cognitive dysmetria and dysmetria of thought models propose that abnormalities of the cerebellum may contribute to schizophrenia signs and symptoms. The cerebellum and cerebral cortex are reciprocally connected via a modular, closed-loop network architecture, but few schizophrenia neuroimaging studies have taken into account the topographical and functional heterogeneity of the cerebellum. In this study, using a previously defined 17-network cerebral cortical parcellation system as the basis for our functional connectivity seeds, we systematically investigated connectivity abnormalities within the cerebellum of 44 schizophrenia patients and 28 healthy control participants. We found selective alterations in cerebro-cerebellar functional connectivity. Specifically, schizophrenia patients showed decreased cerebro-cerebellar functional connectivity in higher level association networks (ventral attention, salience, control, and default mode networks) relative to healthy control participants. Schizophrenia patients also showed increased cerebro-cerebellar connectivity in somatomotor and default mode networks, with the latter showing no overlap with the regions found to be hypoconnected within the same default mode network. Finally, we found evidence to suggest that somatomotor and default mode networks may be inappropriately linked in schizophrenia. The relationship of these dysconnectivities to schizophrenia symptoms, such as neurological soft signs and altered sense of agency, is discussed. We conclude that the cerebellum ought to be considered for analysis in all future studies of network abnormalities in SZ, and further suggest the cerebellum as a potential target for further elucidation, and possibly treatment, of the underlying mechanisms and network abnormalities producing symptoms of schizophrenia. |
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issn | 1662-5161 |
language | English |
last_indexed | 2024-04-13T04:03:59Z |
publishDate | 2015-03-01 |
publisher | Frontiers Media S.A. |
record_format | Article |
series | Frontiers in Human Neuroscience |
spelling | doaj.art-05fb0a4e9cc1454da1cc432f6d951f482022-12-22T03:03:21ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612015-03-01910.3389/fnhum.2015.00134121129Aberrant cerebellar connectivity in motor and association networks in schizophreniaAnn K. Shinn0Ann K. Shinn1Justin T. Baker2Justin T. Baker3Kathryn Eve Lewandowski4Kathryn Eve Lewandowski5Dost eOngur6Dost eOngur7Bruce M. Cohen8Bruce M. Cohen9McLean HospitalHarvard Medical SchoolMcLean HospitalHarvard Medical SchoolMcLean HospitalHarvard Medical SchoolMcLean HospitalHarvard Medical SchoolMcLean HospitalHarvard Medical SchoolSchizophrenia is a devastating illness characterized by disturbances in multiple domains. The cerebellum is involved in both motor and non-motor functions, and the cognitive dysmetria and dysmetria of thought models propose that abnormalities of the cerebellum may contribute to schizophrenia signs and symptoms. The cerebellum and cerebral cortex are reciprocally connected via a modular, closed-loop network architecture, but few schizophrenia neuroimaging studies have taken into account the topographical and functional heterogeneity of the cerebellum. In this study, using a previously defined 17-network cerebral cortical parcellation system as the basis for our functional connectivity seeds, we systematically investigated connectivity abnormalities within the cerebellum of 44 schizophrenia patients and 28 healthy control participants. We found selective alterations in cerebro-cerebellar functional connectivity. Specifically, schizophrenia patients showed decreased cerebro-cerebellar functional connectivity in higher level association networks (ventral attention, salience, control, and default mode networks) relative to healthy control participants. Schizophrenia patients also showed increased cerebro-cerebellar connectivity in somatomotor and default mode networks, with the latter showing no overlap with the regions found to be hypoconnected within the same default mode network. Finally, we found evidence to suggest that somatomotor and default mode networks may be inappropriately linked in schizophrenia. The relationship of these dysconnectivities to schizophrenia symptoms, such as neurological soft signs and altered sense of agency, is discussed. We conclude that the cerebellum ought to be considered for analysis in all future studies of network abnormalities in SZ, and further suggest the cerebellum as a potential target for further elucidation, and possibly treatment, of the underlying mechanisms and network abnormalities producing symptoms of schizophrenia.http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00134/fullCerebellumSchizophreniafunctional connectivitynetworksmotorassociation cortex |
spellingShingle | Ann K. Shinn Ann K. Shinn Justin T. Baker Justin T. Baker Kathryn Eve Lewandowski Kathryn Eve Lewandowski Dost eOngur Dost eOngur Bruce M. Cohen Bruce M. Cohen Aberrant cerebellar connectivity in motor and association networks in schizophrenia Frontiers in Human Neuroscience Cerebellum Schizophrenia functional connectivity networks motor association cortex |
title | Aberrant cerebellar connectivity in motor and association networks in schizophrenia |
title_full | Aberrant cerebellar connectivity in motor and association networks in schizophrenia |
title_fullStr | Aberrant cerebellar connectivity in motor and association networks in schizophrenia |
title_full_unstemmed | Aberrant cerebellar connectivity in motor and association networks in schizophrenia |
title_short | Aberrant cerebellar connectivity in motor and association networks in schizophrenia |
title_sort | aberrant cerebellar connectivity in motor and association networks in schizophrenia |
topic | Cerebellum Schizophrenia functional connectivity networks motor association cortex |
url | http://journal.frontiersin.org/Journal/10.3389/fnhum.2015.00134/full |
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