Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions
Background: HIV cure-directed clinical trials using analytical treatment interruptions (ATIs) require participants to adhere to frequent monitoring visits for viral load tests. Novel viral load monitoring strategies are needed to decrease participant burden during ATIs. Objective: To examine accepta...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2022-08-01
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| Series: | HIV Research & Clinical Practice |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/25787489.2022.2103582 |
| _version_ | 1797661027352969216 |
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| author | Karine Dubé Harsh Agarwal William B. Carter Lynda Dee Jeff Taylor Christopher Roebuck Beth Peterson Hursch Patel Samuel Ndukwe Kenneth M. Lynn Linden Lalley-Chareczko Emily Hiserodt Sukyung Kim Daniel Rosenbloom Brad R. Evans Melanie Anderson Daria J. Hazuda Kevin Bateman Bonnie J. Howell Livio Azzoni Karam Mounzer Pablo Tebas Luis J. Montaner |
| author_facet | Karine Dubé Harsh Agarwal William B. Carter Lynda Dee Jeff Taylor Christopher Roebuck Beth Peterson Hursch Patel Samuel Ndukwe Kenneth M. Lynn Linden Lalley-Chareczko Emily Hiserodt Sukyung Kim Daniel Rosenbloom Brad R. Evans Melanie Anderson Daria J. Hazuda Kevin Bateman Bonnie J. Howell Livio Azzoni Karam Mounzer Pablo Tebas Luis J. Montaner |
| author_sort | Karine Dubé |
| collection | DOAJ |
| description | Background: HIV cure-directed clinical trials using analytical treatment interruptions (ATIs) require participants to adhere to frequent monitoring visits for viral load tests. Novel viral load monitoring strategies are needed to decrease participant burden during ATIs. Objective: To examine acceptability of a novel home-based blood collection device for viral load testing in the context of two ongoing ATI trials in Philadelphia, PA, United States. Methods: From January 2021 to February 2022, participants completed three in-depth interviews via teleconference during their participation in an ATI: (1) within two weeks of enrollment in the device study, (2) approximately four weeks after beginning to use the device, and (3) within two weeks of the end of the ATI when ART was re-initiated. We used conventional content analysis to analyze the data. Results: We recruited 17 participants: 15 were cisgender males, 1 cisgender female, and 1 transgender woman. We observed an overall 87% success rate in drawing blood with the device from home collection and found overall high acceptance of the device. A mean of 91.5 devices per participant were used for home-based blood collection. Most PWH viewed the device as relatively convenient, painless, easy to use, and a simple solution to frequent blood draws. The main challenge encountered was the inability to completely fill up devices with blood in some cases. Most participants reported positive experiences with mailing blood samples and could see themselves using the device on a regular basis outside of ATIs. Conclusions: Our study showed participant valued the novel home-based peripheral blood collection for viral load testing in the context of ATI trials. More research will be necessary to optimize implementation of the device and to assess whether blood collected can reliably measure viral loads in the context of ATI trials. |
| first_indexed | 2024-03-11T18:39:25Z |
| format | Article |
| id | doaj.art-05fbd233a40d4f83afda13ea5699851d |
| institution | Directory Open Access Journal |
| issn | 2578-7470 |
| language | English |
| last_indexed | 2024-03-11T18:39:25Z |
| publishDate | 2022-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | HIV Research & Clinical Practice |
| spelling | doaj.art-05fbd233a40d4f83afda13ea5699851d2023-10-12T13:43:53ZengTaylor & Francis GroupHIV Research & Clinical Practice2578-74702022-08-01231769010.1080/25787489.2022.21035822103582Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptionsKarine Dubé0Harsh Agarwal1William B. Carter2Lynda Dee3Jeff Taylor4Christopher Roebuck5Beth Peterson6Hursch Patel7Samuel Ndukwe8Kenneth M. Lynn9Linden Lalley-Chareczko10Emily Hiserodt11Sukyung Kim12Daniel Rosenbloom13Brad R. Evans14Melanie Anderson15Daria J. Hazuda16Kevin Bateman17Bonnie J. Howell18Livio Azzoni19Karam Mounzer20Pablo Tebas21Luis J. Montaner22UNC Gillings School of Global Public HealthUNC Gillings School of Global Public HealthBEAT-HIV Delaney Collaboratory Community Advisory Board (CAB)AIDS Treatment Activists Coalition (ATAC), NationwideAIDS Treatment Activists Coalition (ATAC), NationwideDepartment of Science and Technology Studies, Cornell UniversityWistar Institute and BEAT-HIV Delaney CollaboratoryUNC Gillings School of Global Public HealthUNC Gillings School of Global Public HealthHospital of the University of PennsylvaniaPhiladelphia FIGHT Community Health CentersPhiladelphia FIGHT Community Health CentersHospital of the University of PennsylvaniaMerck & Co, IncMerck & Co, IncMerck & Co, IncMerck & Co, IncMerck & Co, IncMerck & Co, IncWistar Institute and BEAT-HIV Delaney CollaboratoryPhiladelphia FIGHT Community Health CentersHospital of the University of PennsylvaniaWistar Institute and BEAT-HIV Delaney CollaboratoryBackground: HIV cure-directed clinical trials using analytical treatment interruptions (ATIs) require participants to adhere to frequent monitoring visits for viral load tests. Novel viral load monitoring strategies are needed to decrease participant burden during ATIs. Objective: To examine acceptability of a novel home-based blood collection device for viral load testing in the context of two ongoing ATI trials in Philadelphia, PA, United States. Methods: From January 2021 to February 2022, participants completed three in-depth interviews via teleconference during their participation in an ATI: (1) within two weeks of enrollment in the device study, (2) approximately four weeks after beginning to use the device, and (3) within two weeks of the end of the ATI when ART was re-initiated. We used conventional content analysis to analyze the data. Results: We recruited 17 participants: 15 were cisgender males, 1 cisgender female, and 1 transgender woman. We observed an overall 87% success rate in drawing blood with the device from home collection and found overall high acceptance of the device. A mean of 91.5 devices per participant were used for home-based blood collection. Most PWH viewed the device as relatively convenient, painless, easy to use, and a simple solution to frequent blood draws. The main challenge encountered was the inability to completely fill up devices with blood in some cases. Most participants reported positive experiences with mailing blood samples and could see themselves using the device on a regular basis outside of ATIs. Conclusions: Our study showed participant valued the novel home-based peripheral blood collection for viral load testing in the context of ATI trials. More research will be necessary to optimize implementation of the device and to assess whether blood collected can reliably measure viral loads in the context of ATI trials.http://dx.doi.org/10.1080/25787489.2022.2103582home-based blood collectionexperimental deviceself-testviral loadparticipant experiencesacceptabilityhiv cure researchanalytical treatment interruptionspeople with hiv |
| spellingShingle | Karine Dubé Harsh Agarwal William B. Carter Lynda Dee Jeff Taylor Christopher Roebuck Beth Peterson Hursch Patel Samuel Ndukwe Kenneth M. Lynn Linden Lalley-Chareczko Emily Hiserodt Sukyung Kim Daniel Rosenbloom Brad R. Evans Melanie Anderson Daria J. Hazuda Kevin Bateman Bonnie J. Howell Livio Azzoni Karam Mounzer Pablo Tebas Luis J. Montaner Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions HIV Research & Clinical Practice home-based blood collection experimental device self-test viral load participant experiences acceptability hiv cure research analytical treatment interruptions people with hiv |
| title | Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions |
| title_full | Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions |
| title_fullStr | Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions |
| title_full_unstemmed | Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions |
| title_short | Participant experiences using novel home-based blood collection device for viral load testing in HIV cure trials with analytical treatment interruptions |
| title_sort | participant experiences using novel home based blood collection device for viral load testing in hiv cure trials with analytical treatment interruptions |
| topic | home-based blood collection experimental device self-test viral load participant experiences acceptability hiv cure research analytical treatment interruptions people with hiv |
| url | http://dx.doi.org/10.1080/25787489.2022.2103582 |
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