TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases

TIE2 Induces Breast Cancer Cell Dormancy and Inhibits the Development of Osteolytic Bone Metastases

Breast cancer (BCa) cells disseminating to the bone can remain dormant and resistant to treatments for many years until relapsing as bone metastases. The tyrosine kinase receptor TIE2 induces the dormancy of hematopoietic stem cells, and could also induce the dormancy of BCa cells. However, TIE2 is...

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Bibliographic Details
Main Authors: Florian Drescher, Patricia Juárez, Danna L. Arellano, Nicolás Serafín-Higuera, Felipe Olvera-Rodriguez, Samanta Jiménez, Alexei F. Licea-Navarro, Pierrick G.J. Fournier
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
breast cancer
bone metastasis
dormancy
TIE2
chemotherapy resistance
cancer relapse
Online Access:https://www.mdpi.com/2072-6694/12/4/868

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