Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.
Schizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reor...
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Public Library of Science (PLoS)
2016-01-01
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Online Access: | http://europepmc.org/articles/PMC4757444?pdf=render |
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author | Cristina Solé-Padullés Josefina Castro-Fornieles Elena de la Serna Soledad Romero Anna Calvo Vanessa Sánchez-Gistau Marta Padrós-Fornieles Inmaculada Baeza Núria Bargalló Sophia Frangou Gisela Sugranyes |
author_facet | Cristina Solé-Padullés Josefina Castro-Fornieles Elena de la Serna Soledad Romero Anna Calvo Vanessa Sánchez-Gistau Marta Padrós-Fornieles Inmaculada Baeza Núria Bargalló Sophia Frangou Gisela Sugranyes |
author_sort | Cristina Solé-Padullés |
collection | DOAJ |
description | Schizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reorganization during youth coinciding with the period of increased incidence for both disorders. We therefore focused on characterizing resting state network connectivity in youth at familial risk for SZ or BD to identify alterations arising during this period. We measured resting-state functional connectivity in a sample of 106 youth, aged 7-19 years, comprising offspring of patients with SZ (N = 27), offspring of patients with BD (N = 39) and offspring of community control parents (N = 40). We used Independent Component Analysis to assess functional connectivity within the default mode, executive control, salience and basal ganglia networks and define their relationship to grey matter volume, clinical and cognitive measures. There was no difference in connectivity within any of the networks examined between offspring of patients with BD and offspring of community controls. In contrast, offspring of patients with SZ showed reduced connectivity within the left basal ganglia network compared to control offspring, and they showed a positive correlation between connectivity in this network and grey matter volume in the left caudate. Our findings suggest that dysconnectivity in the basal ganglia network is a robust correlate of familial risk for SZ and can be detected during childhood and adolescence. |
first_indexed | 2024-12-13T07:41:34Z |
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id | doaj.art-05fbd3a3aafe40d482d9ec3f3d5b8ff7 |
institution | Directory Open Access Journal |
issn | 1932-6203 |
language | English |
last_indexed | 2024-12-13T07:41:34Z |
publishDate | 2016-01-01 |
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spelling | doaj.art-05fbd3a3aafe40d482d9ec3f3d5b8ff72022-12-21T23:54:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014804510.1371/journal.pone.0148045Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.Cristina Solé-PadullésJosefina Castro-FornielesElena de la SernaSoledad RomeroAnna CalvoVanessa Sánchez-GistauMarta Padrós-FornielesInmaculada BaezaNúria BargallóSophia FrangouGisela SugranyesSchizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reorganization during youth coinciding with the period of increased incidence for both disorders. We therefore focused on characterizing resting state network connectivity in youth at familial risk for SZ or BD to identify alterations arising during this period. We measured resting-state functional connectivity in a sample of 106 youth, aged 7-19 years, comprising offspring of patients with SZ (N = 27), offspring of patients with BD (N = 39) and offspring of community control parents (N = 40). We used Independent Component Analysis to assess functional connectivity within the default mode, executive control, salience and basal ganglia networks and define their relationship to grey matter volume, clinical and cognitive measures. There was no difference in connectivity within any of the networks examined between offspring of patients with BD and offspring of community controls. In contrast, offspring of patients with SZ showed reduced connectivity within the left basal ganglia network compared to control offspring, and they showed a positive correlation between connectivity in this network and grey matter volume in the left caudate. Our findings suggest that dysconnectivity in the basal ganglia network is a robust correlate of familial risk for SZ and can be detected during childhood and adolescence.http://europepmc.org/articles/PMC4757444?pdf=render |
spellingShingle | Cristina Solé-Padullés Josefina Castro-Fornieles Elena de la Serna Soledad Romero Anna Calvo Vanessa Sánchez-Gistau Marta Padrós-Fornieles Inmaculada Baeza Núria Bargalló Sophia Frangou Gisela Sugranyes Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls. PLoS ONE |
title | Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls. |
title_full | Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls. |
title_fullStr | Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls. |
title_full_unstemmed | Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls. |
title_short | Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls. |
title_sort | altered cortico striatal connectivity in offspring of schizophrenia patients relative to offspring of bipolar patients and controls |
url | http://europepmc.org/articles/PMC4757444?pdf=render |
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