Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.

Schizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reor...

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Main Authors: Cristina Solé-Padullés, Josefina Castro-Fornieles, Elena de la Serna, Soledad Romero, Anna Calvo, Vanessa Sánchez-Gistau, Marta Padrós-Fornieles, Inmaculada Baeza, Núria Bargalló, Sophia Frangou, Gisela Sugranyes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4757444?pdf=render
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author Cristina Solé-Padullés
Josefina Castro-Fornieles
Elena de la Serna
Soledad Romero
Anna Calvo
Vanessa Sánchez-Gistau
Marta Padrós-Fornieles
Inmaculada Baeza
Núria Bargalló
Sophia Frangou
Gisela Sugranyes
author_facet Cristina Solé-Padullés
Josefina Castro-Fornieles
Elena de la Serna
Soledad Romero
Anna Calvo
Vanessa Sánchez-Gistau
Marta Padrós-Fornieles
Inmaculada Baeza
Núria Bargalló
Sophia Frangou
Gisela Sugranyes
author_sort Cristina Solé-Padullés
collection DOAJ
description Schizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reorganization during youth coinciding with the period of increased incidence for both disorders. We therefore focused on characterizing resting state network connectivity in youth at familial risk for SZ or BD to identify alterations arising during this period. We measured resting-state functional connectivity in a sample of 106 youth, aged 7-19 years, comprising offspring of patients with SZ (N = 27), offspring of patients with BD (N = 39) and offspring of community control parents (N = 40). We used Independent Component Analysis to assess functional connectivity within the default mode, executive control, salience and basal ganglia networks and define their relationship to grey matter volume, clinical and cognitive measures. There was no difference in connectivity within any of the networks examined between offspring of patients with BD and offspring of community controls. In contrast, offspring of patients with SZ showed reduced connectivity within the left basal ganglia network compared to control offspring, and they showed a positive correlation between connectivity in this network and grey matter volume in the left caudate. Our findings suggest that dysconnectivity in the basal ganglia network is a robust correlate of familial risk for SZ and can be detected during childhood and adolescence.
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spelling doaj.art-05fbd3a3aafe40d482d9ec3f3d5b8ff72022-12-21T23:54:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014804510.1371/journal.pone.0148045Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.Cristina Solé-PadullésJosefina Castro-FornielesElena de la SernaSoledad RomeroAnna CalvoVanessa Sánchez-GistauMarta Padrós-FornielesInmaculada BaezaNúria BargallóSophia FrangouGisela SugranyesSchizophrenia (SZ) and bipolar disorder (BD) share clinical features, genetic risk factors and neuroimaging abnormalities. There is evidence of disrupted connectivity in resting state networks in patients with SZ and BD and their unaffected relatives. Resting state networks are known to undergo reorganization during youth coinciding with the period of increased incidence for both disorders. We therefore focused on characterizing resting state network connectivity in youth at familial risk for SZ or BD to identify alterations arising during this period. We measured resting-state functional connectivity in a sample of 106 youth, aged 7-19 years, comprising offspring of patients with SZ (N = 27), offspring of patients with BD (N = 39) and offspring of community control parents (N = 40). We used Independent Component Analysis to assess functional connectivity within the default mode, executive control, salience and basal ganglia networks and define their relationship to grey matter volume, clinical and cognitive measures. There was no difference in connectivity within any of the networks examined between offspring of patients with BD and offspring of community controls. In contrast, offspring of patients with SZ showed reduced connectivity within the left basal ganglia network compared to control offspring, and they showed a positive correlation between connectivity in this network and grey matter volume in the left caudate. Our findings suggest that dysconnectivity in the basal ganglia network is a robust correlate of familial risk for SZ and can be detected during childhood and adolescence.http://europepmc.org/articles/PMC4757444?pdf=render
spellingShingle Cristina Solé-Padullés
Josefina Castro-Fornieles
Elena de la Serna
Soledad Romero
Anna Calvo
Vanessa Sánchez-Gistau
Marta Padrós-Fornieles
Inmaculada Baeza
Núria Bargalló
Sophia Frangou
Gisela Sugranyes
Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.
PLoS ONE
title Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.
title_full Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.
title_fullStr Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.
title_full_unstemmed Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.
title_short Altered Cortico-Striatal Connectivity in Offspring of Schizophrenia Patients Relative to Offspring of Bipolar Patients and Controls.
title_sort altered cortico striatal connectivity in offspring of schizophrenia patients relative to offspring of bipolar patients and controls
url http://europepmc.org/articles/PMC4757444?pdf=render
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