Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screening
Abstract Breast cancer screening has substantially reduced mortality across screening populations. However, a clinical need persists for more accessible, cost-effective, and robust approaches for increased-risk and diverse patient populations, especially those with dense breasts where screening mamm...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-41424-7 |
| _version_ | 1797452825753550848 |
|---|---|
| author | Claire Keun Sun Park Tiana Trumpour Amal Aziz Jeffrey Scott Bax David Tessier Lori Gardi Aaron Fenster |
| author_facet | Claire Keun Sun Park Tiana Trumpour Amal Aziz Jeffrey Scott Bax David Tessier Lori Gardi Aaron Fenster |
| author_sort | Claire Keun Sun Park |
| collection | DOAJ |
| description | Abstract Breast cancer screening has substantially reduced mortality across screening populations. However, a clinical need persists for more accessible, cost-effective, and robust approaches for increased-risk and diverse patient populations, especially those with dense breasts where screening mammography is suboptimal. We developed and validated a cost-effective, portable, patient-dedicated three-dimensional (3D) automated breast ultrasound (ABUS) system for point-of-care breast cancer screening. The 3D ABUS system contains a wearable, rapid-prototype 3D-printed dam assembly, a compression assembly, and a computer-driven 3DUS scanner, adaptable to any commercially available US machine and transducer. Acquisition is operator-agnostic, involves a 40-second scan time, and provides multiplanar 3D visualization for whole-breast assessment. Geometric reconstruction accuracy was evaluated with a 3D grid phantom and tissue-mimicking breast phantoms, demonstrating linear measurement and volumetric reconstruction errors < 0.2 mm and < 3%, respectively. The system’s capability was demonstrated in a healthy male volunteer and two healthy female volunteers, representing diverse patient geometries and breast sizes. The system enables comfortable ultrasonic coupling and tissue stabilization, with adjustable compression to improve image quality while alleviating discomfort. Moreover, the system effectively mitigates breathing and motion, since its assembly affixes directly onto the patient. While future studies are still required to evaluate the impact on current clinical practices and workflow, the 3D ABUS system shows potential for adoption as an alternative, cost-effective, dedicated point-of-care breast cancer screening approach for increased-risk populations and limited-resource settings. |
| first_indexed | 2024-03-09T15:14:16Z |
| format | Article |
| id | doaj.art-05fe86852a7741a3acd336ced71e2a2a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:14:16Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-05fe86852a7741a3acd336ced71e2a2a2023-11-26T13:09:49ZengNature PortfolioScientific Reports2045-23222023-09-0113111610.1038/s41598-023-41424-7Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screeningClaire Keun Sun Park0Tiana Trumpour1Amal Aziz2Jeffrey Scott Bax3David Tessier4Lori Gardi5Aaron Fenster6Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western UniversityDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western UniversityRobarts Research InstituteRobarts Research InstituteRobarts Research InstituteRobarts Research InstituteDepartment of Medical Biophysics, Schulich School of Medicine and Dentistry, Western UniversityAbstract Breast cancer screening has substantially reduced mortality across screening populations. However, a clinical need persists for more accessible, cost-effective, and robust approaches for increased-risk and diverse patient populations, especially those with dense breasts where screening mammography is suboptimal. We developed and validated a cost-effective, portable, patient-dedicated three-dimensional (3D) automated breast ultrasound (ABUS) system for point-of-care breast cancer screening. The 3D ABUS system contains a wearable, rapid-prototype 3D-printed dam assembly, a compression assembly, and a computer-driven 3DUS scanner, adaptable to any commercially available US machine and transducer. Acquisition is operator-agnostic, involves a 40-second scan time, and provides multiplanar 3D visualization for whole-breast assessment. Geometric reconstruction accuracy was evaluated with a 3D grid phantom and tissue-mimicking breast phantoms, demonstrating linear measurement and volumetric reconstruction errors < 0.2 mm and < 3%, respectively. The system’s capability was demonstrated in a healthy male volunteer and two healthy female volunteers, representing diverse patient geometries and breast sizes. The system enables comfortable ultrasonic coupling and tissue stabilization, with adjustable compression to improve image quality while alleviating discomfort. Moreover, the system effectively mitigates breathing and motion, since its assembly affixes directly onto the patient. While future studies are still required to evaluate the impact on current clinical practices and workflow, the 3D ABUS system shows potential for adoption as an alternative, cost-effective, dedicated point-of-care breast cancer screening approach for increased-risk populations and limited-resource settings.https://doi.org/10.1038/s41598-023-41424-7 |
| spellingShingle | Claire Keun Sun Park Tiana Trumpour Amal Aziz Jeffrey Scott Bax David Tessier Lori Gardi Aaron Fenster Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screening Scientific Reports |
| title | Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screening |
| title_full | Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screening |
| title_fullStr | Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screening |
| title_full_unstemmed | Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screening |
| title_short | Cost-effective, portable, patient-dedicated three-dimensional automated breast ultrasound for point-of-care breast cancer screening |
| title_sort | cost effective portable patient dedicated three dimensional automated breast ultrasound for point of care breast cancer screening |
| url | https://doi.org/10.1038/s41598-023-41424-7 |
| work_keys_str_mv | AT clairekeunsunpark costeffectiveportablepatientdedicatedthreedimensionalautomatedbreastultrasoundforpointofcarebreastcancerscreening AT tianatrumpour costeffectiveportablepatientdedicatedthreedimensionalautomatedbreastultrasoundforpointofcarebreastcancerscreening AT amalaziz costeffectiveportablepatientdedicatedthreedimensionalautomatedbreastultrasoundforpointofcarebreastcancerscreening AT jeffreyscottbax costeffectiveportablepatientdedicatedthreedimensionalautomatedbreastultrasoundforpointofcarebreastcancerscreening AT davidtessier costeffectiveportablepatientdedicatedthreedimensionalautomatedbreastultrasoundforpointofcarebreastcancerscreening AT lorigardi costeffectiveportablepatientdedicatedthreedimensionalautomatedbreastultrasoundforpointofcarebreastcancerscreening AT aaronfenster costeffectiveportablepatientdedicatedthreedimensionalautomatedbreastultrasoundforpointofcarebreastcancerscreening |