αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies.
BACKGROUND: Cataract and geographic atrophy (GA, also called advanced "dry" age-related macular degeneration) are the two major causes of visual impairment in the developed world. The association between cataract surgery and the development of GA was controversial in previous studies. METH...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3423426?pdf=render |
| _version_ | 1811285977300205568 |
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| author | Peng Zhou Hong-Fei Ye Yong-Xiang Jiang Jin Yang Xiang-Jia Zhu Xing-Huai Sun Yi Luo Guo-Rui Dou Yu-Sheng Wang Yi Lu |
| author_facet | Peng Zhou Hong-Fei Ye Yong-Xiang Jiang Jin Yang Xiang-Jia Zhu Xing-Huai Sun Yi Luo Guo-Rui Dou Yu-Sheng Wang Yi Lu |
| author_sort | Peng Zhou |
| collection | DOAJ |
| description | BACKGROUND: Cataract and geographic atrophy (GA, also called advanced "dry" age-related macular degeneration) are the two major causes of visual impairment in the developed world. The association between cataract surgery and the development of GA was controversial in previous studies. METHODS/PRINCIPAL FINDINGS: We performed a meta-analysis by pooling the current evidence in literature and found that cataract is associated with an increased risk of geographic atrophy with a summary odds ratio (OR) of 3.75 (95% CI: 95% CI: 1.84-7.62). However, cataract surgery is not associated with the risk of geographic atrophy (polled OR=3.23, 95% CI: 0.63-16.47). Further experiments were performed to analyze how the αA-crystallin, the major component of the lens, influences the development of GA in a mouse model. We found that theαA-crystallin mRNA and protein expression increased after oxidative stress induced by NaIO(3) in immunohistochemistry of retinal section and western blot of posterior eyecups. Both functional and histopathological evidence confirmed that GA is more severe in αA-crystallin knockout mice compared to wild-type mice. CONCLUSIONS: Therefore, αA-crystallin may protect against geographic atrophy. This study provides a better understanding of the relationship between cataract, cataract surgery, and GA. |
| first_indexed | 2024-04-13T02:52:50Z |
| format | Article |
| id | doaj.art-05ffc6c4fd2a4343a7253bf2d3ad18d5 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T02:52:50Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-05ffc6c4fd2a4343a7253bf2d3ad18d52022-12-22T03:05:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0178e4317310.1371/journal.pone.0043173αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies.Peng ZhouHong-Fei YeYong-Xiang JiangJin YangXiang-Jia ZhuXing-Huai SunYi LuoGuo-Rui DouYu-Sheng WangYi LuBACKGROUND: Cataract and geographic atrophy (GA, also called advanced "dry" age-related macular degeneration) are the two major causes of visual impairment in the developed world. The association between cataract surgery and the development of GA was controversial in previous studies. METHODS/PRINCIPAL FINDINGS: We performed a meta-analysis by pooling the current evidence in literature and found that cataract is associated with an increased risk of geographic atrophy with a summary odds ratio (OR) of 3.75 (95% CI: 95% CI: 1.84-7.62). However, cataract surgery is not associated with the risk of geographic atrophy (polled OR=3.23, 95% CI: 0.63-16.47). Further experiments were performed to analyze how the αA-crystallin, the major component of the lens, influences the development of GA in a mouse model. We found that theαA-crystallin mRNA and protein expression increased after oxidative stress induced by NaIO(3) in immunohistochemistry of retinal section and western blot of posterior eyecups. Both functional and histopathological evidence confirmed that GA is more severe in αA-crystallin knockout mice compared to wild-type mice. CONCLUSIONS: Therefore, αA-crystallin may protect against geographic atrophy. This study provides a better understanding of the relationship between cataract, cataract surgery, and GA.http://europepmc.org/articles/PMC3423426?pdf=render |
| spellingShingle | Peng Zhou Hong-Fei Ye Yong-Xiang Jiang Jin Yang Xiang-Jia Zhu Xing-Huai Sun Yi Luo Guo-Rui Dou Yu-Sheng Wang Yi Lu αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies. PLoS ONE |
| title | αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies. |
| title_full | αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies. |
| title_fullStr | αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies. |
| title_full_unstemmed | αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies. |
| title_short | αA crystallin may protect against geographic atrophy-meta-analysis of cataract vs. cataract surgery for geographic atrophy and experimental studies. |
| title_sort | αa crystallin may protect against geographic atrophy meta analysis of cataract vs cataract surgery for geographic atrophy and experimental studies |
| url | http://europepmc.org/articles/PMC3423426?pdf=render |
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