Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States and worldwide. Though nonalcoholic fatty liver per se may not be independently associated with an increased risk for all-cause mortality, it is associated with a number of harmful metaboli...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2023-02-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-2022-0351.pdf |
| _version_ | 1797871482204848128 |
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| author | Peter Konyn Aijaz Ahmed Donghee Kim |
| author_facet | Peter Konyn Aijaz Ahmed Donghee Kim |
| author_sort | Peter Konyn |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States and worldwide. Though nonalcoholic fatty liver per se may not be independently associated with an increased risk for all-cause mortality, it is associated with a number of harmful metabolic risk factors, such as type 2 diabetes mellitus, hyperlipidemia, obesity, a sedentary lifestyle, and an unhealthy diet. The fibrosis stage is a predictor of all-cause mortality in NAFLD. Mortality in individuals with NAFLD has been steadily increasing, and the most common cause-specific mortality for NAFLD is cardiovascular disease, followed by extra-hepatic cancer, liver-related mortality, and diabetes. High-risk profiles for mortality in NAFLD include PNPLA3 I148M polymorphism, low thyroid function and hypothyroidism, and sarcopenia. Achieving weight loss through adherence to a high-quality diet and sufficient physical activity is the most important predictor of improvement in NAFLD severity and the benefit of survival. Given the increasing health burden of NAFLD, future studies with more long-term mortality data may demonstrate an independent association between NAFLD and mortality. |
| first_indexed | 2024-04-10T00:44:36Z |
| format | Article |
| id | doaj.art-06005c9aff5f4e69a4b7bb20400a9acb |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-04-10T00:44:36Z |
| publishDate | 2023-02-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-06005c9aff5f4e69a4b7bb20400a9acb2023-03-14T01:46:51ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2023-02-0129SupplS43S5710.3350/cmh.2022.03511729Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver diseasePeter Konyn0Aijaz Ahmed1Donghee Kim2 Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USA Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA, USANonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States and worldwide. Though nonalcoholic fatty liver per se may not be independently associated with an increased risk for all-cause mortality, it is associated with a number of harmful metabolic risk factors, such as type 2 diabetes mellitus, hyperlipidemia, obesity, a sedentary lifestyle, and an unhealthy diet. The fibrosis stage is a predictor of all-cause mortality in NAFLD. Mortality in individuals with NAFLD has been steadily increasing, and the most common cause-specific mortality for NAFLD is cardiovascular disease, followed by extra-hepatic cancer, liver-related mortality, and diabetes. High-risk profiles for mortality in NAFLD include PNPLA3 I148M polymorphism, low thyroid function and hypothyroidism, and sarcopenia. Achieving weight loss through adherence to a high-quality diet and sufficient physical activity is the most important predictor of improvement in NAFLD severity and the benefit of survival. Given the increasing health burden of NAFLD, future studies with more long-term mortality data may demonstrate an independent association between NAFLD and mortality.http://e-cmh.org/upload/pdf/cmh-2022-0351.pdfnon-alcoholic fatty liver disease and fatty liverdeathrisk factornashoutcome |
| spellingShingle | Peter Konyn Aijaz Ahmed Donghee Kim Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease Clinical and Molecular Hepatology non-alcoholic fatty liver disease and fatty liver death risk factor nash outcome |
| title | Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease |
| title_full | Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease |
| title_fullStr | Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease |
| title_full_unstemmed | Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease |
| title_short | Causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease |
| title_sort | causes and risk profiles of mortality among individuals with nonalcoholic fatty liver disease |
| topic | non-alcoholic fatty liver disease and fatty liver death risk factor nash outcome |
| url | http://e-cmh.org/upload/pdf/cmh-2022-0351.pdf |
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