Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy?
Abstract Differences in concordance rates between monozygotic and dizygotic twin pairs with Parkinson's disease (PD) have been used to estimate genetic influences in PD pathogenesis. We hypothesized that “discordance” may not in all cases adequately reflect the multifaceted disease manifestatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-06-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.775 |
| _version_ | 1818722572595888128 |
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| author | Alexander Balck Max Borsche Meike Kasten Katja Lohmann Philip Seibler Norbert Brüggemann Christine Klein |
| author_facet | Alexander Balck Max Borsche Meike Kasten Katja Lohmann Philip Seibler Norbert Brüggemann Christine Klein |
| author_sort | Alexander Balck |
| collection | DOAJ |
| description | Abstract Differences in concordance rates between monozygotic and dizygotic twin pairs with Parkinson's disease (PD) have been used to estimate genetic influences in PD pathogenesis. We hypothesized that “discordance” may not in all cases adequately reflect the multifaceted disease manifestation of PD that involves a continuum from prodromal to definite PD. Deep clinical phenotyping, combining motor, nonmotor, and imaging modalities in five monozygotic, seemingly discordant twin pairs revealed motor and/or nonmotor features and/or nigral hyperechogenicity in all of the five putatively unaffected twins. In conclusion, our data suggest that concordance rates in monozygotic twins may be higher than previously appreciated. |
| first_indexed | 2024-12-17T20:56:46Z |
| format | Article |
| id | doaj.art-0600cf4f69f547559e18fcfb3beda649 |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-17T20:56:46Z |
| publishDate | 2019-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-0600cf4f69f547559e18fcfb3beda6492022-12-21T21:32:50ZengWileyAnnals of Clinical and Translational Neurology2328-95032019-06-01661102110510.1002/acn3.775Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy?Alexander Balck0Max Borsche1Meike Kasten2Katja Lohmann3Philip Seibler4Norbert Brüggemann5Christine Klein6Institute of Neurogenetics University of Lübeck Lübeck GermanyInstitute of Neurogenetics University of Lübeck Lübeck GermanyInstitute of Neurogenetics University of Lübeck Lübeck GermanyInstitute of Neurogenetics University of Lübeck Lübeck GermanyInstitute of Neurogenetics University of Lübeck Lübeck GermanyInstitute of Neurogenetics University of Lübeck Lübeck GermanyInstitute of Neurogenetics University of Lübeck Lübeck GermanyAbstract Differences in concordance rates between monozygotic and dizygotic twin pairs with Parkinson's disease (PD) have been used to estimate genetic influences in PD pathogenesis. We hypothesized that “discordance” may not in all cases adequately reflect the multifaceted disease manifestation of PD that involves a continuum from prodromal to definite PD. Deep clinical phenotyping, combining motor, nonmotor, and imaging modalities in five monozygotic, seemingly discordant twin pairs revealed motor and/or nonmotor features and/or nigral hyperechogenicity in all of the five putatively unaffected twins. In conclusion, our data suggest that concordance rates in monozygotic twins may be higher than previously appreciated.https://doi.org/10.1002/acn3.775 |
| spellingShingle | Alexander Balck Max Borsche Meike Kasten Katja Lohmann Philip Seibler Norbert Brüggemann Christine Klein Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy? Annals of Clinical and Translational Neurology |
| title | Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy? |
| title_full | Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy? |
| title_fullStr | Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy? |
| title_full_unstemmed | Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy? |
| title_short | Discordance in monozygotic Parkinson's disease twins – continuum or dichotomy? |
| title_sort | discordance in monozygotic parkinson s disease twins continuum or dichotomy |
| url | https://doi.org/10.1002/acn3.775 |
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