Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis
Metastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multi...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.656851/full |
| _version_ | 1818922850972598272 |
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| author | Ana Hipólito Ana Hipólito Filipa Martins Filipa Martins Cindy Mendes Cindy Mendes Filipa Lopes-Coelho Filipa Lopes-Coelho Jacinta Serpa Jacinta Serpa |
| author_facet | Ana Hipólito Ana Hipólito Filipa Martins Filipa Martins Cindy Mendes Cindy Mendes Filipa Lopes-Coelho Filipa Lopes-Coelho Jacinta Serpa Jacinta Serpa |
| author_sort | Ana Hipólito |
| collection | DOAJ |
| description | Metastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multistep process encompasses the dissemination of cancer cells to distant organs, followed by their adaptation to foreign microenvironments and establishment in secondary tumors. During the last decades, it was discovered that these events may be favored by particular metabolic patterns, which are dependent on reprogrammed signaling pathways in cancer cells while they acquire metastatic traits. In this review, we present current knowledge of molecular mechanisms that coordinate the crosstalk between metastatic signaling and cellular metabolism. The recent findings involving the contribution of crucial metabolic pathways involved in the bioenergetics and biosynthesis control in metastatic cells are summarized. Finally, we highlight new promising metabolism-based therapeutic strategies as a putative way of impairing metastasis. |
| first_indexed | 2024-12-20T02:00:06Z |
| format | Article |
| id | doaj.art-0600ff37bf154085b5129d8916f8b36f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-20T02:00:06Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-0600ff37bf154085b5129d8916f8b36f2022-12-21T19:57:22ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.656851656851Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor MetastasisAna Hipólito0Ana Hipólito1Filipa Martins2Filipa Martins3Cindy Mendes4Cindy Mendes5Filipa Lopes-Coelho6Filipa Lopes-Coelho7Jacinta Serpa8Jacinta Serpa9CEDOC, Chronic Diseases Research Centre, NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, PortugalUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisboa, PortugalCEDOC, Chronic Diseases Research Centre, NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, PortugalUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisboa, PortugalCEDOC, Chronic Diseases Research Centre, NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, PortugalUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisboa, PortugalCEDOC, Chronic Diseases Research Centre, NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, PortugalUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisboa, PortugalCEDOC, Chronic Diseases Research Centre, NOVA Medical School|Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisboa, PortugalUnidade de Investigação em Patobiologia Molecular (UIPM), Instituto Português de Oncologia de Lisboa Francisco Gentil (IPOLFG), Lisboa, PortugalMetastasis is a major hurdle to the efficient treatment of cancer, accounting for the great majority of cancer-related deaths. Although several studies have disclosed the detailed mechanisms underlying primary tumor formation, the emergence of metastatic disease remains poorly understood. This multistep process encompasses the dissemination of cancer cells to distant organs, followed by their adaptation to foreign microenvironments and establishment in secondary tumors. During the last decades, it was discovered that these events may be favored by particular metabolic patterns, which are dependent on reprogrammed signaling pathways in cancer cells while they acquire metastatic traits. In this review, we present current knowledge of molecular mechanisms that coordinate the crosstalk between metastatic signaling and cellular metabolism. The recent findings involving the contribution of crucial metabolic pathways involved in the bioenergetics and biosynthesis control in metastatic cells are summarized. Finally, we highlight new promising metabolism-based therapeutic strategies as a putative way of impairing metastasis.https://www.frontiersin.org/articles/10.3389/fonc.2021.656851/fullmetabolic reprogrammingmetastasismetastatic cascadetumor microenvironmentnew therapies |
| spellingShingle | Ana Hipólito Ana Hipólito Filipa Martins Filipa Martins Cindy Mendes Cindy Mendes Filipa Lopes-Coelho Filipa Lopes-Coelho Jacinta Serpa Jacinta Serpa Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis Frontiers in Oncology metabolic reprogramming metastasis metastatic cascade tumor microenvironment new therapies |
| title | Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis |
| title_full | Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis |
| title_fullStr | Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis |
| title_full_unstemmed | Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis |
| title_short | Molecular and Metabolic Reprogramming: Pulling the Strings Toward Tumor Metastasis |
| title_sort | molecular and metabolic reprogramming pulling the strings toward tumor metastasis |
| topic | metabolic reprogramming metastasis metastatic cascade tumor microenvironment new therapies |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.656851/full |
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