Role of EGFR in the Nervous System
Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/8/1887 |
| _version_ | 1797558773843230720 |
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| author | Roberta Romano Cecilia Bucci |
| author_facet | Roberta Romano Cecilia Bucci |
| author_sort | Roberta Romano |
| collection | DOAJ |
| description | Epidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR in the regulation of tissue development and homeostasis has been thoroughly investigated and it has also been demonstrated that EGFR is a driver of tumorigenesis. In the nervous system, other growth factors, and thus other receptors, are important for growth, differentiation and repair of the tissue, namely neurotrophins and neurotrophins receptors. For this reason, for a long time, the role of EGFR in the nervous system has been underestimated and poorly investigated. However, EGFR is expressed both in the central and peripheral nervous systems and it has been demonstrated to have specific important neurotrophic functions, in particular in the central nervous system. This review discusses the role of EGFR in regulating differentiation and functions of neurons and neuroglia. Furthermore, its involvement in regeneration after injury and in the onset of neurodegenerative diseases is examined. |
| first_indexed | 2024-03-10T17:35:08Z |
| format | Article |
| id | doaj.art-0602a3ad26ad4d4e957bb52803e5d1d7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T17:35:08Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0602a3ad26ad4d4e957bb52803e5d1d72023-11-20T09:51:36ZengMDPI AGCells2073-44092020-08-0198188710.3390/cells9081887Role of EGFR in the Nervous SystemRoberta Romano0Cecilia Bucci1Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, 73100 Lecce, ItalyDepartment of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, 73100 Lecce, ItalyEpidermal growth factor receptor (EGFR) is the first discovered member of the receptor tyrosine kinase superfamily and plays a fundamental role during embryogenesis and in adult tissues, being involved in growth, differentiation, maintenance and repair of various tissues and organs. The role of EGFR in the regulation of tissue development and homeostasis has been thoroughly investigated and it has also been demonstrated that EGFR is a driver of tumorigenesis. In the nervous system, other growth factors, and thus other receptors, are important for growth, differentiation and repair of the tissue, namely neurotrophins and neurotrophins receptors. For this reason, for a long time, the role of EGFR in the nervous system has been underestimated and poorly investigated. However, EGFR is expressed both in the central and peripheral nervous systems and it has been demonstrated to have specific important neurotrophic functions, in particular in the central nervous system. This review discusses the role of EGFR in regulating differentiation and functions of neurons and neuroglia. Furthermore, its involvement in regeneration after injury and in the onset of neurodegenerative diseases is examined.https://www.mdpi.com/2073-4409/9/8/1887EGFEGFRperipheral nervous systemcentral nervous systemneuronsbrain |
| spellingShingle | Roberta Romano Cecilia Bucci Role of EGFR in the Nervous System Cells EGF EGFR peripheral nervous system central nervous system neurons brain |
| title | Role of EGFR in the Nervous System |
| title_full | Role of EGFR in the Nervous System |
| title_fullStr | Role of EGFR in the Nervous System |
| title_full_unstemmed | Role of EGFR in the Nervous System |
| title_short | Role of EGFR in the Nervous System |
| title_sort | role of egfr in the nervous system |
| topic | EGF EGFR peripheral nervous system central nervous system neurons brain |
| url | https://www.mdpi.com/2073-4409/9/8/1887 |
| work_keys_str_mv | AT robertaromano roleofegfrinthenervoussystem AT ceciliabucci roleofegfrinthenervoussystem |