Heterogeneity of Bovine Peripheral Blood Monocytes
Peripheral blood monocytes of several species can be divided into different subpopulations with distinct phenotypic and functional properties. Herein, we aim at reviewing published work regarding the heterogeneity of the recently characterized bovine monocyte subsets. As the heterogeneity of human b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-12-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01875/full |
| _version_ | 1818152222031085568 |
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| author | Jamal Hussen Jamal Hussen Hans-Joachim Schuberth |
| author_facet | Jamal Hussen Jamal Hussen Hans-Joachim Schuberth |
| author_sort | Jamal Hussen |
| collection | DOAJ |
| description | Peripheral blood monocytes of several species can be divided into different subpopulations with distinct phenotypic and functional properties. Herein, we aim at reviewing published work regarding the heterogeneity of the recently characterized bovine monocyte subsets. As the heterogeneity of human blood monocytes was widely studied and reviewed, this work focuses on comparing bovine monocyte subsets with their human counterparts regarding their phenotype, adhesion and migration properties, inflammatory and antimicrobial functions, and their ability to interact with neutrophilic granulocytes. In addition, the differentiation of monocyte subsets into functionally polarized macrophages is discussed. Regarding phenotype and distribution in blood, bovine monocyte subsets share similarities with their human counterparts. However, many functional differences exist between monocyte subsets from the two species. In contrast to their pro-inflammatory functions in human, bovine non-classical monocytes show the lowest phagocytosis and reactive oxygen species generation capacity, an absent ability to produce the pro-inflammatory cytokine IL-1β after inflammasome activation, and do not have a role in the early recruitment of neutrophils into inflamed tissues. Classical and intermediate monocytes of both species also differ in their response toward major monocyte-attracting chemokines (CCL2 and CCL5) and neutrophil degranulation products (DGP) in vitro. Such differences between homologous monocyte subsets also extend to the development of monocyte-derived macrophages under the influence of chemokines like CCL5 and neutrophil DGP. Whereas the latter induce the differentiation of M1-polarized macrophages in human, bovine monocyte-derived macrophages develop a mixed M1/M2 macrophage phenotype. Although only a few bovine clinical trials analyzed the correlation between changes in monocyte composition and disease, they suggest that functional differences between human and bovine monocyte subsets are also reflected in their different clinical relevance for distinct diseases. In opposite to the human system, where higher blood cell number of non-classical monocytes was widely correlated with several human infectious and non-infectious diseases, higher counts of bovine intermediate monocytes are suggested as a potential biomarker for inflammatory responses postpartum. |
| first_indexed | 2024-12-11T13:51:17Z |
| format | Article |
| id | doaj.art-06039d14af6e4d3da1a512c57cb8e635 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T13:51:17Z |
| publishDate | 2017-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-06039d14af6e4d3da1a512c57cb8e6352022-12-22T01:04:16ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-12-01810.3389/fimmu.2017.01875312543Heterogeneity of Bovine Peripheral Blood MonocytesJamal Hussen0Jamal Hussen1Hans-Joachim Schuberth2Department of Microbiology and Parasitology, College of Veterinary Medicine, King Faisal University, Al Ahsa, Hofuf, Saudi ArabiaImmunology Unit, University of Veterinary Medicine, Hannover, GermanyImmunology Unit, University of Veterinary Medicine, Hannover, GermanyPeripheral blood monocytes of several species can be divided into different subpopulations with distinct phenotypic and functional properties. Herein, we aim at reviewing published work regarding the heterogeneity of the recently characterized bovine monocyte subsets. As the heterogeneity of human blood monocytes was widely studied and reviewed, this work focuses on comparing bovine monocyte subsets with their human counterparts regarding their phenotype, adhesion and migration properties, inflammatory and antimicrobial functions, and their ability to interact with neutrophilic granulocytes. In addition, the differentiation of monocyte subsets into functionally polarized macrophages is discussed. Regarding phenotype and distribution in blood, bovine monocyte subsets share similarities with their human counterparts. However, many functional differences exist between monocyte subsets from the two species. In contrast to their pro-inflammatory functions in human, bovine non-classical monocytes show the lowest phagocytosis and reactive oxygen species generation capacity, an absent ability to produce the pro-inflammatory cytokine IL-1β after inflammasome activation, and do not have a role in the early recruitment of neutrophils into inflamed tissues. Classical and intermediate monocytes of both species also differ in their response toward major monocyte-attracting chemokines (CCL2 and CCL5) and neutrophil degranulation products (DGP) in vitro. Such differences between homologous monocyte subsets also extend to the development of monocyte-derived macrophages under the influence of chemokines like CCL5 and neutrophil DGP. Whereas the latter induce the differentiation of M1-polarized macrophages in human, bovine monocyte-derived macrophages develop a mixed M1/M2 macrophage phenotype. Although only a few bovine clinical trials analyzed the correlation between changes in monocyte composition and disease, they suggest that functional differences between human and bovine monocyte subsets are also reflected in their different clinical relevance for distinct diseases. In opposite to the human system, where higher blood cell number of non-classical monocytes was widely correlated with several human infectious and non-infectious diseases, higher counts of bovine intermediate monocytes are suggested as a potential biomarker for inflammatory responses postpartum.http://journal.frontiersin.org/article/10.3389/fimmu.2017.01875/fullmonocyte subsetsmonocyte heterogeneitybovinemacrophagesmonocyte migration |
| spellingShingle | Jamal Hussen Jamal Hussen Hans-Joachim Schuberth Heterogeneity of Bovine Peripheral Blood Monocytes Frontiers in Immunology monocyte subsets monocyte heterogeneity bovine macrophages monocyte migration |
| title | Heterogeneity of Bovine Peripheral Blood Monocytes |
| title_full | Heterogeneity of Bovine Peripheral Blood Monocytes |
| title_fullStr | Heterogeneity of Bovine Peripheral Blood Monocytes |
| title_full_unstemmed | Heterogeneity of Bovine Peripheral Blood Monocytes |
| title_short | Heterogeneity of Bovine Peripheral Blood Monocytes |
| title_sort | heterogeneity of bovine peripheral blood monocytes |
| topic | monocyte subsets monocyte heterogeneity bovine macrophages monocyte migration |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.01875/full |
| work_keys_str_mv | AT jamalhussen heterogeneityofbovineperipheralbloodmonocytes AT jamalhussen heterogeneityofbovineperipheralbloodmonocytes AT hansjoachimschuberth heterogeneityofbovineperipheralbloodmonocytes |