The Diversity of Muscles and Their Regenerative Potential across Animals
Cells with contractile functions are present in almost all metazoans, and so are the related processes of muscle homeostasis and regeneration. Regeneration itself is a complex process unevenly spread across metazoans that ranges from full-body regeneration to partial reconstruction of damaged organs...
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MDPI AG
2020-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/9/1925 |
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| author | Letizia Zullo Matteo Bozzo Alon Daya Alessio Di Clemente Francesco Paolo Mancini Aram Megighian Nir Nesher Eric Röttinger Tal Shomrat Stefano Tiozzo Alberto Zullo Simona Candiani |
| author_facet | Letizia Zullo Matteo Bozzo Alon Daya Alessio Di Clemente Francesco Paolo Mancini Aram Megighian Nir Nesher Eric Röttinger Tal Shomrat Stefano Tiozzo Alberto Zullo Simona Candiani |
| author_sort | Letizia Zullo |
| collection | DOAJ |
| description | Cells with contractile functions are present in almost all metazoans, and so are the related processes of muscle homeostasis and regeneration. Regeneration itself is a complex process unevenly spread across metazoans that ranges from full-body regeneration to partial reconstruction of damaged organs or body tissues, including muscles. The cellular and molecular mechanisms involved in regenerative processes can be homologous, co-opted, and/or evolved independently. By comparing the mechanisms of muscle homeostasis and regeneration throughout the diversity of animal body-plans and life cycles, it is possible to identify conserved and divergent cellular and molecular mechanisms underlying muscle plasticity. In this review we aim at providing an overview of muscle regeneration studies in metazoans, highlighting the major regenerative strategies and molecular pathways involved. By gathering these findings, we wish to advocate a comparative and evolutionary approach to prompt a wider use of “non-canonical” animal models for molecular and even pharmacological studies in the field of muscle regeneration. |
| first_indexed | 2024-03-10T17:09:34Z |
| format | Article |
| id | doaj.art-0603c1d4842a43b18b273a1555fe0c03 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T17:09:34Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0603c1d4842a43b18b273a1555fe0c032023-11-20T10:41:26ZengMDPI AGCells2073-44092020-08-0199192510.3390/cells9091925The Diversity of Muscles and Their Regenerative Potential across AnimalsLetizia Zullo0Matteo Bozzo1Alon Daya2Alessio Di Clemente3Francesco Paolo Mancini4Aram Megighian5Nir Nesher6Eric Röttinger7Tal Shomrat8Stefano Tiozzo9Alberto Zullo10Simona Candiani11Istituto Italiano di Tecnologia, Center for Micro-BioRobotics & Center for Synaptic Neuroscience and Technology (NSYN), 16132 Genova, ItalyLaboratory of Developmental Neurobiology, Department of Earth, Environment and Life Sciences, University of Genova, Viale Benedetto XV 5, 16132 Genova, ItalyFaculty of Marine Sciences, Ruppin Academic Center, Michmoret 40297, IsraelIstituto Italiano di Tecnologia, Center for Micro-BioRobotics & Center for Synaptic Neuroscience and Technology (NSYN), 16132 Genova, ItalyDepartment of Science and Technology, University of Sannio, 82100 Benevento, ItalyDepartment of Biomedical Sciences, University of Padova, 35131 Padova, ItalyFaculty of Marine Sciences, Ruppin Academic Center, Michmoret 40297, IsraelInstitute for Research on Cancer and Aging (IRCAN), Université Côte d’Azur, CNRS, INSERM, 06107 Nice, FranceFaculty of Marine Sciences, Ruppin Academic Center, Michmoret 40297, IsraelLaboratoire de Biologie du Développement de Villefranche-sur-Mer (LBDV), Sorbonne Université, CNRS, 06230 Paris, FranceDepartment of Science and Technology, University of Sannio, 82100 Benevento, ItalyLaboratory of Developmental Neurobiology, Department of Earth, Environment and Life Sciences, University of Genova, Viale Benedetto XV 5, 16132 Genova, ItalyCells with contractile functions are present in almost all metazoans, and so are the related processes of muscle homeostasis and regeneration. Regeneration itself is a complex process unevenly spread across metazoans that ranges from full-body regeneration to partial reconstruction of damaged organs or body tissues, including muscles. The cellular and molecular mechanisms involved in regenerative processes can be homologous, co-opted, and/or evolved independently. By comparing the mechanisms of muscle homeostasis and regeneration throughout the diversity of animal body-plans and life cycles, it is possible to identify conserved and divergent cellular and molecular mechanisms underlying muscle plasticity. In this review we aim at providing an overview of muscle regeneration studies in metazoans, highlighting the major regenerative strategies and molecular pathways involved. By gathering these findings, we wish to advocate a comparative and evolutionary approach to prompt a wider use of “non-canonical” animal models for molecular and even pharmacological studies in the field of muscle regeneration.https://www.mdpi.com/2073-4409/9/9/1925myogenesisevolutionmetazoansdifferentiationtransdifferentiationmuscle precursors |
| spellingShingle | Letizia Zullo Matteo Bozzo Alon Daya Alessio Di Clemente Francesco Paolo Mancini Aram Megighian Nir Nesher Eric Röttinger Tal Shomrat Stefano Tiozzo Alberto Zullo Simona Candiani The Diversity of Muscles and Their Regenerative Potential across Animals Cells myogenesis evolution metazoans differentiation transdifferentiation muscle precursors |
| title | The Diversity of Muscles and Their Regenerative Potential across Animals |
| title_full | The Diversity of Muscles and Their Regenerative Potential across Animals |
| title_fullStr | The Diversity of Muscles and Their Regenerative Potential across Animals |
| title_full_unstemmed | The Diversity of Muscles and Their Regenerative Potential across Animals |
| title_short | The Diversity of Muscles and Their Regenerative Potential across Animals |
| title_sort | diversity of muscles and their regenerative potential across animals |
| topic | myogenesis evolution metazoans differentiation transdifferentiation muscle precursors |
| url | https://www.mdpi.com/2073-4409/9/9/1925 |
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