Analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance
Diabetes type 2 is a chronic metabolic disorder. Pathogenesis of diabetes type 2 results from the impaired insulin secretion, impaired insulin action and increased endogenous glucose production. Diabetes evolves through several phases characterized by qualitative and quantitative changes of beta cel...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Serbian Medical Society
2006-01-01
|
| Series: | Srpski Arhiv za Celokupno Lekarstvo |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0370-8179/2006/0370-81790606219P.pdf |
| _version_ | 1818886755034595328 |
|---|---|
| author | Popović Ljiljana Zamaklar Miroslava Lalić Katarina Vasović Olga |
| author_facet | Popović Ljiljana Zamaklar Miroslava Lalić Katarina Vasović Olga |
| author_sort | Popović Ljiljana |
| collection | DOAJ |
| description | Diabetes type 2 is a chronic metabolic disorder. Pathogenesis of diabetes type 2 results from the impaired insulin secretion, impaired insulin action and increased endogenous glucose production. Diabetes evolves through several phases characterized by qualitative and quantitative changes of beta cell secretory function. The aim of our study was to analyze the impact of diabetes duration on beta cell secretory function and insulin resistance. The results indicated significant negative correlation of diabetes duration and fasting insulinemia, as well as beta cell secretory function assessed by HOMA β index. Our study also found significant negative correlation of diabetes duration and insulin resistance assessed by HOMA IR index. Significant positive correlation was established between beta cell secretory capacity (fasting insulinemia and HOMA β) and insulin resistance assessed by HOMA IR index, independently of diabetes duration. These results indicate that: beta cell secretory capacity, assessed by HOMA β index, significantly decreases with diabetes duration. In parallel with decrease of fasting insulinemia, reduction of insulin resistance assessed by HOMA IR index was found as well. |
| first_indexed | 2024-12-19T16:26:22Z |
| format | Article |
| id | doaj.art-0607c2240ad748ad9f59c80f63816447 |
| institution | Directory Open Access Journal |
| issn | 0370-8179 |
| language | English |
| last_indexed | 2024-12-19T16:26:22Z |
| publishDate | 2006-01-01 |
| publisher | Serbian Medical Society |
| record_format | Article |
| series | Srpski Arhiv za Celokupno Lekarstvo |
| spelling | doaj.art-0607c2240ad748ad9f59c80f638164472022-12-21T20:14:19ZengSerbian Medical SocietySrpski Arhiv za Celokupno Lekarstvo0370-81792006-01-011345-621922310.2298/SARH0606219PAnalysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistancePopović LjiljanaZamaklar MiroslavaLalić KatarinaVasović OlgaDiabetes type 2 is a chronic metabolic disorder. Pathogenesis of diabetes type 2 results from the impaired insulin secretion, impaired insulin action and increased endogenous glucose production. Diabetes evolves through several phases characterized by qualitative and quantitative changes of beta cell secretory function. The aim of our study was to analyze the impact of diabetes duration on beta cell secretory function and insulin resistance. The results indicated significant negative correlation of diabetes duration and fasting insulinemia, as well as beta cell secretory function assessed by HOMA β index. Our study also found significant negative correlation of diabetes duration and insulin resistance assessed by HOMA IR index. Significant positive correlation was established between beta cell secretory capacity (fasting insulinemia and HOMA β) and insulin resistance assessed by HOMA IR index, independently of diabetes duration. These results indicate that: beta cell secretory capacity, assessed by HOMA β index, significantly decreases with diabetes duration. In parallel with decrease of fasting insulinemia, reduction of insulin resistance assessed by HOMA IR index was found as well.http://www.doiserbia.nb.rs/img/doi/0370-8179/2006/0370-81790606219P.pdfdiabetes type 2insulin secretioninsulin resistancediabetes duration |
| spellingShingle | Popović Ljiljana Zamaklar Miroslava Lalić Katarina Vasović Olga Analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance Srpski Arhiv za Celokupno Lekarstvo diabetes type 2 insulin secretion insulin resistance diabetes duration |
| title | Analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance |
| title_full | Analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance |
| title_fullStr | Analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance |
| title_full_unstemmed | Analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance |
| title_short | Analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance |
| title_sort | analysis of the effect of diabetes type 2 duration on beta cell secretory function and insulin resistance |
| topic | diabetes type 2 insulin secretion insulin resistance diabetes duration |
| url | http://www.doiserbia.nb.rs/img/doi/0370-8179/2006/0370-81790606219P.pdf |
| work_keys_str_mv | AT popovicljiljana analysisoftheeffectofdiabetestype2durationonbetacellsecretoryfunctionandinsulinresistance AT zamaklarmiroslava analysisoftheeffectofdiabetestype2durationonbetacellsecretoryfunctionandinsulinresistance AT lalickatarina analysisoftheeffectofdiabetestype2durationonbetacellsecretoryfunctionandinsulinresistance AT vasovicolga analysisoftheeffectofdiabetestype2durationonbetacellsecretoryfunctionandinsulinresistance |