Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients
Introduction. The study of dialysis patients not needing erythropoiesis-stimulating agents (ESA) for long periods of time has gained interest lately. The aim of this study was to compare laboratory and clinical parameters in hemodialysis patients with autosomal dominant polycystic kidney disease (AD...
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| Format: | Article |
| Language: | English |
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Sciendo
2017-10-01
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| Series: | Romanian Journal of Laboratory Medicine |
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| Online Access: | https://doi.org/10.1515/rrlm-2017-0032 |
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| author | Orăsan Olga Hilda Petrov Ljubomir Urian Laura Cozma Angela Ciulei George Patiu Ioan Mihai Orăsan Remus Aurel |
| author_facet | Orăsan Olga Hilda Petrov Ljubomir Urian Laura Cozma Angela Ciulei George Patiu Ioan Mihai Orăsan Remus Aurel |
| author_sort | Orăsan Olga Hilda |
| collection | DOAJ |
| description | Introduction. The study of dialysis patients not needing erythropoiesis-stimulating agents (ESA) for long periods of time has gained interest lately. The aim of this study was to compare laboratory and clinical parameters in hemodialysis patients with autosomal dominant polycystic kidney disease (ADPKD) treated or not with ESA. Methods. Forty-six hemodialysis ADPKD patients were studied for 8 months and they were divided into: group 1- 29 patients who received ESA during the study period and group 2- 17 patients with no ESA treatment. The following parameters were determined: weekly treatment time, body mass index (BMI), pre-session diastolic blood pressure (DBP), pre-session systolic blood pressure (SBP), blood volume processed (BVD), interdialytic body weight gain (IBWG), spKt/V -K/DOQI formula (Kt/V), urea distribution volume (UDV), hemoglobin (Hb), ferritin, transferrin saturation (TSAT), serum phosphate, total serum calcium, normalized protein catabolic ratio (nPCR), albumin, and intact parathormone (PTH). Results. Patients not requiring ESA were more likely to be men, had higher Hb, albumin, total serum calcium levels, IBWG, UDV, BVP, and weekly treatment time. They had lower ferritin, TSAT, SBP. There was no difference regarding DBP, BMI, serum phosphate, PTH, Kt/V, and nPCR. Conclusion. Hemodialysis ADPKD patients not treated with ESA seem to be better nourished, with a slightly better SBP control, with longer dialysis time and increased Hb (despite lower iron loading markers), compared to hemodialysis ADPKD patients treated with ESA. |
| first_indexed | 2024-12-17T12:10:44Z |
| format | Article |
| id | doaj.art-06083eb0407940a08fca785c967948c4 |
| institution | Directory Open Access Journal |
| issn | 2284-5623 |
| language | English |
| last_indexed | 2024-12-17T12:10:44Z |
| publishDate | 2017-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Romanian Journal of Laboratory Medicine |
| spelling | doaj.art-06083eb0407940a08fca785c967948c42022-12-21T21:49:25ZengSciendoRomanian Journal of Laboratory Medicine2284-56232017-10-0125437538210.1515/rrlm-2017-0032rrlm-2017-0032Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patientsOrăsan Olga Hilda0Petrov Ljubomir1Urian Laura2Cozma Angela3Ciulei George4Patiu Ioan Mihai5Orăsan Remus Aurel64th Medical Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, RomaniaHemathology Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, RomaniaHemathology Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania4th Medical Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, Romania4th Medical Department, University of Medicine and Pharmacy Iuliu Hatieganu, Cluj-Napoca, RomaniaNefromed Dialysis Center, Cluj-Napoca, RomaniaNefromed Dialysis Center, Cluj-Napoca, RomaniaIntroduction. The study of dialysis patients not needing erythropoiesis-stimulating agents (ESA) for long periods of time has gained interest lately. The aim of this study was to compare laboratory and clinical parameters in hemodialysis patients with autosomal dominant polycystic kidney disease (ADPKD) treated or not with ESA. Methods. Forty-six hemodialysis ADPKD patients were studied for 8 months and they were divided into: group 1- 29 patients who received ESA during the study period and group 2- 17 patients with no ESA treatment. The following parameters were determined: weekly treatment time, body mass index (BMI), pre-session diastolic blood pressure (DBP), pre-session systolic blood pressure (SBP), blood volume processed (BVD), interdialytic body weight gain (IBWG), spKt/V -K/DOQI formula (Kt/V), urea distribution volume (UDV), hemoglobin (Hb), ferritin, transferrin saturation (TSAT), serum phosphate, total serum calcium, normalized protein catabolic ratio (nPCR), albumin, and intact parathormone (PTH). Results. Patients not requiring ESA were more likely to be men, had higher Hb, albumin, total serum calcium levels, IBWG, UDV, BVP, and weekly treatment time. They had lower ferritin, TSAT, SBP. There was no difference regarding DBP, BMI, serum phosphate, PTH, Kt/V, and nPCR. Conclusion. Hemodialysis ADPKD patients not treated with ESA seem to be better nourished, with a slightly better SBP control, with longer dialysis time and increased Hb (despite lower iron loading markers), compared to hemodialysis ADPKD patients treated with ESA.https://doi.org/10.1515/rrlm-2017-0032autosomal dominant polycystic kidney diseaseerythropoiesis-stimulating agentsanemiahemodialysis |
| spellingShingle | Orăsan Olga Hilda Petrov Ljubomir Urian Laura Cozma Angela Ciulei George Patiu Ioan Mihai Orăsan Remus Aurel Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients Romanian Journal of Laboratory Medicine autosomal dominant polycystic kidney disease erythropoiesis-stimulating agents anemia hemodialysis |
| title | Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients |
| title_full | Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients |
| title_fullStr | Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients |
| title_full_unstemmed | Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients |
| title_short | Effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients |
| title_sort | effect of long period treatment with erythropoiesis stimulating agents on clinically and laboratory parameters in hemodialysis autosomal dominant polycystic kidney disease patients |
| topic | autosomal dominant polycystic kidney disease erythropoiesis-stimulating agents anemia hemodialysis |
| url | https://doi.org/10.1515/rrlm-2017-0032 |
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