Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease
Cerebral small vessel disease (SVD) is one of the leading causes of cognitive impairment and stroke. The importance of endothelial dysfunction and high blood−brain barrier (BBB) permeability in pathogenesis, together with ischemia, is under discussion. The aim of this study was to clarify...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-10-01
|
| Series: | Brain Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3425/9/10/266 |
| _version_ | 1811327531623645184 |
|---|---|
| author | Larisa A. Dobrynina Alla A. Shabalina Maryam R. Zabitova Elena I. Kremneva Zukhra Sh. Gadzhieva Marina V. Krotenkova Elena V. Gnedovskaya Alexander B. Berdalin Lyudmila A. Kalashnikova |
| author_facet | Larisa A. Dobrynina Alla A. Shabalina Maryam R. Zabitova Elena I. Kremneva Zukhra Sh. Gadzhieva Marina V. Krotenkova Elena V. Gnedovskaya Alexander B. Berdalin Lyudmila A. Kalashnikova |
| author_sort | Larisa A. Dobrynina |
| collection | DOAJ |
| description | Cerebral small vessel disease (SVD) is one of the leading causes of cognitive impairment and stroke. The importance of endothelial dysfunction and high blood−brain barrier (BBB) permeability in pathogenesis, together with ischemia, is under discussion. The aim of this study was to clarify the relationship between tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), and magnetic resonance imaging (MRI) signs of SVD. We examined 71 patients (23 men and 48 women; mean age: 60.5 ± 6.9 years) with clinical and MRI signs of SVD, and 21 healthy volunteers with normal MRIs. All subjects underwent 3T MRI and measurements of t-PA and PAI-1 levels. An increase in t-PA level is correlated with the volume of white matter hyperintensities (WMH) (<i>R</i> = 0.289, <i>p</i> = 0.034), severity on the Fazekas scale (<i>p</i> = 0.000), and with the size of subcortical (<i>p</i> = 0.002) and semiovale (<i>p</i> = 0.008) perivascular spaces. The PAI-1 level is not correlated with the t-PA level or MRI signs of SVD. The correlation between t-PA and the degree of WMH and perivascular spaces’ enlargement, without a correlation with PAI-1 and lacunes, is consistent with the importance of t-PA in BBB disruption and its role in causing brain damage in SVD. |
| first_indexed | 2024-04-13T15:09:33Z |
| format | Article |
| id | doaj.art-060ac4971ffc43978a8387614ef4dd90 |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-04-13T15:09:33Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-060ac4971ffc43978a8387614ef4dd902022-12-22T02:42:03ZengMDPI AGBrain Sciences2076-34252019-10-0191026610.3390/brainsci9100266brainsci9100266Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel DiseaseLarisa A. Dobrynina0Alla A. Shabalina1Maryam R. Zabitova2Elena I. Kremneva3Zukhra Sh. Gadzhieva4Marina V. Krotenkova5Elena V. Gnedovskaya6Alexander B. Berdalin7Lyudmila A. Kalashnikova8Research Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaResearch Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaResearch Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaResearch Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaResearch Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaResearch Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaResearch Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaFederal State Budgetary Institution "Federal Center for Cerebrovascular Pathology and Stroke", 1, stroenie 10, Ostrovityanova, 117342 Moscow, RussiaResearch Center of Neurology, 80 Volokolamskoe shosse, 125367 Moscow, RussiaCerebral small vessel disease (SVD) is one of the leading causes of cognitive impairment and stroke. The importance of endothelial dysfunction and high blood−brain barrier (BBB) permeability in pathogenesis, together with ischemia, is under discussion. The aim of this study was to clarify the relationship between tissue plasminogen activator (t-PA), plasminogen activator inhibitor (PAI-1), and magnetic resonance imaging (MRI) signs of SVD. We examined 71 patients (23 men and 48 women; mean age: 60.5 ± 6.9 years) with clinical and MRI signs of SVD, and 21 healthy volunteers with normal MRIs. All subjects underwent 3T MRI and measurements of t-PA and PAI-1 levels. An increase in t-PA level is correlated with the volume of white matter hyperintensities (WMH) (<i>R</i> = 0.289, <i>p</i> = 0.034), severity on the Fazekas scale (<i>p</i> = 0.000), and with the size of subcortical (<i>p</i> = 0.002) and semiovale (<i>p</i> = 0.008) perivascular spaces. The PAI-1 level is not correlated with the t-PA level or MRI signs of SVD. The correlation between t-PA and the degree of WMH and perivascular spaces’ enlargement, without a correlation with PAI-1 and lacunes, is consistent with the importance of t-PA in BBB disruption and its role in causing brain damage in SVD.https://www.mdpi.com/2076-3425/9/10/266cerebral small vessel diseasewhite matter hyperintensitiesperivascular spacesendothelial dysfunctiontissue plasminogen activatorblood–brain barrier |
| spellingShingle | Larisa A. Dobrynina Alla A. Shabalina Maryam R. Zabitova Elena I. Kremneva Zukhra Sh. Gadzhieva Marina V. Krotenkova Elena V. Gnedovskaya Alexander B. Berdalin Lyudmila A. Kalashnikova Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease Brain Sciences cerebral small vessel disease white matter hyperintensities perivascular spaces endothelial dysfunction tissue plasminogen activator blood–brain barrier |
| title | Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease |
| title_full | Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease |
| title_fullStr | Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease |
| title_full_unstemmed | Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease |
| title_short | Tissue Plasminogen Activator and MRI Signs of Cerebral Small Vessel Disease |
| title_sort | tissue plasminogen activator and mri signs of cerebral small vessel disease |
| topic | cerebral small vessel disease white matter hyperintensities perivascular spaces endothelial dysfunction tissue plasminogen activator blood–brain barrier |
| url | https://www.mdpi.com/2076-3425/9/10/266 |
| work_keys_str_mv | AT larisaadobrynina tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT allaashabalina tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT maryamrzabitova tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT elenaikremneva tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT zukhrashgadzhieva tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT marinavkrotenkova tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT elenavgnedovskaya tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT alexanderbberdalin tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease AT lyudmilaakalashnikova tissueplasminogenactivatorandmrisignsofcerebralsmallvesseldisease |