Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm
Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare, heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exploration of its pathogenesis and treatment methods...
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| Format: | Article |
| Language: | English |
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Editorial Office of China Oncology
2022-09-01
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| Series: | Zhongguo aizheng zazhi |
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| Online Access: | http://www.china-oncology.com/fileup/1007-3639/PDF/1666588240648-1409686645.pdf |
| _version_ | 1811256798027448320 |
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| author | CUI Lingjun, TIAN Chao, CHENG Zixuan, ZHENG Jiabin, SU Fei, TAN Huangying |
| author_facet | CUI Lingjun, TIAN Chao, CHENG Zixuan, ZHENG Jiabin, SU Fei, TAN Huangying |
| author_sort | CUI Lingjun, TIAN Chao, CHENG Zixuan, ZHENG Jiabin, SU Fei, TAN Huangying |
| collection | DOAJ |
| description | Gastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare, heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exploration of its pathogenesis and treatment methods, the importance of preclinical models has become increasingly prominent. Here we reviewed the published preclinical models such as cell lines, organoid models, patient-derived xenograft models and genetically engineered mouse models. We also discussed the current practical applications of these models and their strengths and weaknesses, to provide threads and directions for future research. |
| first_indexed | 2024-04-12T17:46:44Z |
| format | Article |
| id | doaj.art-060c8fb824fe4d79a25d09370e04ba35 |
| institution | Directory Open Access Journal |
| issn | 1007-3639 |
| language | English |
| last_indexed | 2024-04-12T17:46:44Z |
| publishDate | 2022-09-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj.art-060c8fb824fe4d79a25d09370e04ba352022-12-22T03:22:37ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392022-09-0132977978510.19401/j.cnki.1007-3639.2022.09.004Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasmCUI Lingjun, TIAN Chao, CHENG Zixuan, ZHENG Jiabin, SU Fei, TAN Huangying01. Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China;2. Department of Integrative Oncology, China-Japan Friendship Hospital, Beijing 100029, ChinaGastroenteropancreatic neuroendocrine neoplasm (GEP-NEN) is a rare, heterogeneous tumor that can be divided into neuroendocrine tumor (NET) and neuroendocrine carcinoma (NEC) due to its degree of differentiation. With the gradual deepening of the exploration of its pathogenesis and treatment methods, the importance of preclinical models has become increasingly prominent. Here we reviewed the published preclinical models such as cell lines, organoid models, patient-derived xenograft models and genetically engineered mouse models. We also discussed the current practical applications of these models and their strengths and weaknesses, to provide threads and directions for future research.http://www.china-oncology.com/fileup/1007-3639/PDF/1666588240648-1409686645.pdf|gastroenteropancreatic neuroendocrine neoplasm|cell line|organoid model|patient-derived xenograft model|genetically engineered mouse model |
| spellingShingle | CUI Lingjun, TIAN Chao, CHENG Zixuan, ZHENG Jiabin, SU Fei, TAN Huangying Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm Zhongguo aizheng zazhi |gastroenteropancreatic neuroendocrine neoplasm|cell line|organoid model|patient-derived xenograft model|genetically engineered mouse model |
| title | Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm |
| title_full | Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm |
| title_fullStr | Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm |
| title_full_unstemmed | Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm |
| title_short | Advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm |
| title_sort | advances in preclinical research models for gastroenteropancreatic neuroendocrine neoplasm |
| topic | |gastroenteropancreatic neuroendocrine neoplasm|cell line|organoid model|patient-derived xenograft model|genetically engineered mouse model |
| url | http://www.china-oncology.com/fileup/1007-3639/PDF/1666588240648-1409686645.pdf |
| work_keys_str_mv | AT cuilingjuntianchaochengzixuanzhengjiabinsufeitanhuangying advancesinpreclinicalresearchmodelsforgastroenteropancreaticneuroendocrineneoplasm |