Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

Heterogeneous Expression and Subcellular Localization of Pyruvate Dehydrogenase Complex in Prostate Cancer

BackgroundPyruvate dehydrogenase (PDH) complex converts pyruvate into acetyl-CoA by pyruvate decarboxylation, which drives energy metabolism during cell growth, including prostate cancer (PCa) cell growth. The major catalytic subunit of PDH, PDHA1, is regulated by phosphorylation/dephosphorylation b...

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Bibliographic Details
Main Authors: Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Mælandsmo, Øystein Fodstad, Roberto Llarena, José I. López, Rafael Pulido
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
prostate cancer (PCa)
pyruvate dehydrogenase (PDH)
pyruvate dehydrogenase kinase (PDK)
androgen receptor (AR)
dichloroacetate (DCA)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.873516/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.873516/full

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