Cellular and Molecular Targets of Menthol Actions
Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antiox...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-07-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fphar.2017.00472/full |
| _version_ | 1818007987678085120 |
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| author | Murat Oz Murat Oz Eslam G. El Nebrisi Keun-Hang S. Yang Frank C. Howarth Lina T. Al Kury |
| author_facet | Murat Oz Murat Oz Eslam G. El Nebrisi Keun-Hang S. Yang Frank C. Howarth Lina T. Al Kury |
| author_sort | Murat Oz |
| collection | DOAJ |
| description | Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels. |
| first_indexed | 2024-04-14T05:23:08Z |
| format | Article |
| id | doaj.art-060e01ea5ee74225bb0337bc4e432a2f |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-14T05:23:08Z |
| publishDate | 2017-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-060e01ea5ee74225bb0337bc4e432a2f2022-12-22T02:10:06ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122017-07-01810.3389/fphar.2017.00472268548Cellular and Molecular Targets of Menthol ActionsMurat Oz0Murat Oz1Eslam G. El Nebrisi2Keun-Hang S. Yang3Frank C. Howarth4Lina T. Al Kury5Department of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates UniversityAl Ain, United Arab EmiratesDepartment of Basic Medical Sciences, College of Medicine, Qatar UniversityDoha, QatarDepartment of Pharmacology, College of Medicine and Health Sciences, United Arab Emirates UniversityAl Ain, United Arab EmiratesDepartment of Biological Sciences, Schmid College of Science and Technology, Chapman UniversityOrange, CA, United StatesDepartment of Physiology, College of Medicine and Health Sciences, United Arab Emirates UniversityAl Ain, United Arab EmiratesDepartment of Health Sciences, College of Natural and Health Sciences, Zayed UniversityAbu Dhabi, United Arab EmiratesMenthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels.http://journal.frontiersin.org/article/10.3389/fphar.2017.00472/fullmonoterpenesvoltage-gated ion channelsligand-gated ion channelsTRP channelsmenthol |
| spellingShingle | Murat Oz Murat Oz Eslam G. El Nebrisi Keun-Hang S. Yang Frank C. Howarth Lina T. Al Kury Cellular and Molecular Targets of Menthol Actions Frontiers in Pharmacology monoterpenes voltage-gated ion channels ligand-gated ion channels TRP channels menthol |
| title | Cellular and Molecular Targets of Menthol Actions |
| title_full | Cellular and Molecular Targets of Menthol Actions |
| title_fullStr | Cellular and Molecular Targets of Menthol Actions |
| title_full_unstemmed | Cellular and Molecular Targets of Menthol Actions |
| title_short | Cellular and Molecular Targets of Menthol Actions |
| title_sort | cellular and molecular targets of menthol actions |
| topic | monoterpenes voltage-gated ion channels ligand-gated ion channels TRP channels menthol |
| url | http://journal.frontiersin.org/article/10.3389/fphar.2017.00472/full |
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