Predicting MicroRNA Mediated Gene Regulation between Human and Viruses
MicroRNAs (miRNAs) mediate various biological processes by actively fine-tuning gene expression at the post-transcriptional level. With the identification of numerous human and viral miRNAs, growing evidence has indicated a common role of miRNAs in mediating the interactions between humans and virus...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2018-08-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2073-4409/7/8/100 |
| _version_ | 1797725781265219584 |
|---|---|
| author | Xin Shu Xinyuan Zang Xiaoshuang Liu Jie Yang Jin Wang |
| author_facet | Xin Shu Xinyuan Zang Xiaoshuang Liu Jie Yang Jin Wang |
| author_sort | Xin Shu |
| collection | DOAJ |
| description | MicroRNAs (miRNAs) mediate various biological processes by actively fine-tuning gene expression at the post-transcriptional level. With the identification of numerous human and viral miRNAs, growing evidence has indicated a common role of miRNAs in mediating the interactions between humans and viruses. However, there is only limited information about Cross-Kingdom miRNA target sites from studies. To facilitate an extensive investigation on the interplay among the gene regulatory networks of humans and viruses, we designed a prediction pipeline, mirTarP, that is suitable for miRNA target screening on the genome scale. By applying mirTarP, we constructed the database mirTar, which is a comprehensive miRNA target repository of bidirectional interspecies regulation between viruses and humans. To provide convenient downloading for users from both the molecular biology field and medical field, mirTar classifies viruses according to “ICTV viral category” and the “medical microbiology classification” on the web page. The mirTar database and mirTarP tool are freely available online. |
| first_indexed | 2024-03-12T10:36:12Z |
| format | Article |
| id | doaj.art-060e44b87ebc49a6be58674334129494 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T10:36:12Z |
| publishDate | 2018-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-060e44b87ebc49a6be586743341294942023-09-02T08:36:36ZengMDPI AGCells2073-44092018-08-017810010.3390/cells7080100cells7080100Predicting MicroRNA Mediated Gene Regulation between Human and VirusesXin Shu0Xinyuan Zang1Xiaoshuang Liu2Jie Yang3Jin Wang4The State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210023, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210023, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210023, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210023, ChinaThe State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology, NJU Advanced Institute for Life Sciences (NAILS), School of Life Science, Nanjing University, Nanjing 210023, ChinaMicroRNAs (miRNAs) mediate various biological processes by actively fine-tuning gene expression at the post-transcriptional level. With the identification of numerous human and viral miRNAs, growing evidence has indicated a common role of miRNAs in mediating the interactions between humans and viruses. However, there is only limited information about Cross-Kingdom miRNA target sites from studies. To facilitate an extensive investigation on the interplay among the gene regulatory networks of humans and viruses, we designed a prediction pipeline, mirTarP, that is suitable for miRNA target screening on the genome scale. By applying mirTarP, we constructed the database mirTar, which is a comprehensive miRNA target repository of bidirectional interspecies regulation between viruses and humans. To provide convenient downloading for users from both the molecular biology field and medical field, mirTar classifies viruses according to “ICTV viral category” and the “medical microbiology classification” on the web page. The mirTar database and mirTarP tool are freely available online.http://www.mdpi.com/2073-4409/7/8/100miRNAvirushostCross-Kingdomtarget prediction |
| spellingShingle | Xin Shu Xinyuan Zang Xiaoshuang Liu Jie Yang Jin Wang Predicting MicroRNA Mediated Gene Regulation between Human and Viruses Cells miRNA virus host Cross-Kingdom target prediction |
| title | Predicting MicroRNA Mediated Gene Regulation between Human and Viruses |
| title_full | Predicting MicroRNA Mediated Gene Regulation between Human and Viruses |
| title_fullStr | Predicting MicroRNA Mediated Gene Regulation between Human and Viruses |
| title_full_unstemmed | Predicting MicroRNA Mediated Gene Regulation between Human and Viruses |
| title_short | Predicting MicroRNA Mediated Gene Regulation between Human and Viruses |
| title_sort | predicting microrna mediated gene regulation between human and viruses |
| topic | miRNA virus host Cross-Kingdom target prediction |
| url | http://www.mdpi.com/2073-4409/7/8/100 |
| work_keys_str_mv | AT xinshu predictingmicrornamediatedgeneregulationbetweenhumanandviruses AT xinyuanzang predictingmicrornamediatedgeneregulationbetweenhumanandviruses AT xiaoshuangliu predictingmicrornamediatedgeneregulationbetweenhumanandviruses AT jieyang predictingmicrornamediatedgeneregulationbetweenhumanandviruses AT jinwang predictingmicrornamediatedgeneregulationbetweenhumanandviruses |