The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats
Chronic inflammation and oxidative stress can contribute to the development of cardiovascular diseases. Isoproterenol (ISO), a synthetic catecholamine, is used to study the effects of drugs on cardiotoxicity. Agmatine (AGM) is a type of biogenic amine produced through the decarboxylation of arginine...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2023-12-01
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| Series: | Medicine Science |
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| Online Access: | https://www.medicinescience.org/?mno=167417 |
| _version_ | 1797316498205704192 |
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| author | Zeynep Ulutas Semih Tapsiz Onural Ozhan Mehmet Ediz Sarihan Azibe Yildiz Merve Durhan Nigar Vardi Yilmaz Cigremis Leyla Sahin Buyukkorkmaz Hakan Parlakpinar |
| author_facet | Zeynep Ulutas Semih Tapsiz Onural Ozhan Mehmet Ediz Sarihan Azibe Yildiz Merve Durhan Nigar Vardi Yilmaz Cigremis Leyla Sahin Buyukkorkmaz Hakan Parlakpinar |
| author_sort | Zeynep Ulutas |
| collection | DOAJ |
| description | Chronic inflammation and oxidative stress can contribute to the development of cardiovascular diseases. Isoproterenol (ISO), a synthetic catecholamine, is used to study the effects of drugs on cardiotoxicity. Agmatine (AGM) is a type of biogenic amine produced through the decarboxylation of arginine. The purpose of the current study was to evaluate the effects of AGM against ISO-induced cardiotoxicity due to the described roles of AGM in cardiovascular disease. Four groups of thirty-two Wistar Albino rats were divided equally as control, ISO, AGM+ISO, and ISO+AGM. ISO was administered intraperitoneally (i.p.) twice at a dose of 150 mg/kg, at 24-hour intervals. Prior to and after ISO injection, 20 mg/kg of AGM was injected i.p. Hemodynamic measurements and serum and tissue biochemical analyses were evaluated at the end of the experiment. The levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) in the tissue were measured. In the ISO group, levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were increased significantly (p [Med-Science 2023; 12(4.000): 1290-6] |
| first_indexed | 2024-03-08T03:20:14Z |
| format | Article |
| id | doaj.art-06134379f86b4a26b04f4b68830240d7 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T03:20:14Z |
| publishDate | 2023-12-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-06134379f86b4a26b04f4b68830240d72024-02-12T10:32:08ZengSociety of Turaz BilimMedicine Science2147-06342023-12-011241290610.5455/medscience.2023.08.179167417The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in ratsZeynep Ulutas0Semih Tapsiz1Onural Ozhan2Mehmet Ediz Sarihan3Azibe Yildiz4Merve Durhan5Nigar Vardi6Yilmaz Cigremis7Leyla Sahin Buyukkorkmaz8Hakan Parlakpinar9Department of Cardiology, Faculty of Medicine, Inonu University, Malatya, Turkiye Inonu University, Faculty of Medicine, Undergraduate Student, Malatya, Turkiye Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkiye Department of Emergency, Faculty of Medicine, Inonu University, Malatya, Turkiye Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkiye Department of Medical Biology and Genetics, Faculty of Medicine, Inonu University, Malatya, Turkiye Department of Histology and Embryology, Faculty of Medicine, Inonu University, Malatya, Turkiye Department of Medical Biology and Genetics, Faculty of Medicine, Inonu University, Malatya, Turkiye Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, Turkiye Department of Pharmacology, Faculty of Medicine, Inonu University, Malatya, TurkiyeChronic inflammation and oxidative stress can contribute to the development of cardiovascular diseases. Isoproterenol (ISO), a synthetic catecholamine, is used to study the effects of drugs on cardiotoxicity. Agmatine (AGM) is a type of biogenic amine produced through the decarboxylation of arginine. The purpose of the current study was to evaluate the effects of AGM against ISO-induced cardiotoxicity due to the described roles of AGM in cardiovascular disease. Four groups of thirty-two Wistar Albino rats were divided equally as control, ISO, AGM+ISO, and ISO+AGM. ISO was administered intraperitoneally (i.p.) twice at a dose of 150 mg/kg, at 24-hour intervals. Prior to and after ISO injection, 20 mg/kg of AGM was injected i.p. Hemodynamic measurements and serum and tissue biochemical analyses were evaluated at the end of the experiment. The levels of glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and malondialdehyde (MDA) in the tissue were measured. In the ISO group, levels of lactate dehydrogenase (LDH) and creatine kinase (CK) were increased significantly (p [Med-Science 2023; 12(4.000): 1290-6]https://www.medicinescience.org/?mno=167417agmatineisoproterenolmyocardial injuryoxidative stressrat |
| spellingShingle | Zeynep Ulutas Semih Tapsiz Onural Ozhan Mehmet Ediz Sarihan Azibe Yildiz Merve Durhan Nigar Vardi Yilmaz Cigremis Leyla Sahin Buyukkorkmaz Hakan Parlakpinar The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats Medicine Science agmatine isoproterenol myocardial injury oxidative stress rat |
| title | The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats |
| title_full | The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats |
| title_fullStr | The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats |
| title_full_unstemmed | The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats |
| title_short | The protective and therapeutic effects of agmatine on isoproterenol-induced myocardial injury in rats |
| title_sort | protective and therapeutic effects of agmatine on isoproterenol induced myocardial injury in rats |
| topic | agmatine isoproterenol myocardial injury oxidative stress rat |
| url | https://www.medicinescience.org/?mno=167417 |
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