Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells

Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production via Multiple Mechanisms in Differentiated Airway Epithelial Cells

Human rhinoviruses (HRVs) are associated with acute exacerbations in patients with chronic obstructive pulmonary disease (COPD) and asthma, which are accompanied by mucus hypersecretion. Whereas, various studies have shown that HRVs increase epithelial mucin production and thus may directly contribu...

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Bibliographic Details
Main Authors: Ying Wang, Dennis K. Ninaber, Annemarie van Schadewijk, Pieter S. Hiemstra
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
rhinovirus
exacerbation
tiotropium
fluticasone
mucin production
airway epithelial cells
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00278/full

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