Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer
Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient ho...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2016-05-01
|
| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/14552 |
| _version_ | 1818019070358847488 |
|---|---|
| author | Andrea Strakova Máire Ní Leathlobhair Guo-Dong Wang Ting-Ting Yin Ilona Airikkala-Otter Janice L Allen Karen M Allum Leontine Bansse-Issa Jocelyn L Bisson Artemio Castillo Domracheva Karina F de Castro Anne M Corrigan Hugh R Cran Jane T Crawford Stephen M Cutter Laura Delgadillo Keenan Edward M Donelan Ibikunle A Faramade Erika Flores Reynoso Eleni Fotopoulou Skye N Fruean Fanny Gallardo-Arrieta Olga Glebova Rodrigo F Häfelin Manrique Joaquim JGP Henriques Natalia Ignatenko Debbie Koenig Marta Lanza-Perea Remo Lobetti Adriana M Lopez Quintana Thibault Losfelt Gabriele Marino Inigo Martincorena Simón Martínez Castañeda Mayra F Martínez-López Michael Meyer Berna Nakanwagi Andrigo B De Nardi Winifred Neunzig Sally J Nixon Marsden M Onsare Antonio Ortega-Pacheco Maria C Peleteiro Ruth J Pye John F Reece Jose Rojas Gutierrez Haleema Sadia Sheila K Schmeling Olga Shamanova Richard K Ssuna Audrey E Steenland-Smit Alla Svitich Ismail Thoya Ngoka Bogdan A Vițălaru Anna P de Vos Johan P de Vos Oliver Walkinton David C Wedge Alvaro S Wehrle-Martinez Mirjam G van der Wel Sophie AE Widdowson Elizabeth P Murchison |
| author_facet | Andrea Strakova Máire Ní Leathlobhair Guo-Dong Wang Ting-Ting Yin Ilona Airikkala-Otter Janice L Allen Karen M Allum Leontine Bansse-Issa Jocelyn L Bisson Artemio Castillo Domracheva Karina F de Castro Anne M Corrigan Hugh R Cran Jane T Crawford Stephen M Cutter Laura Delgadillo Keenan Edward M Donelan Ibikunle A Faramade Erika Flores Reynoso Eleni Fotopoulou Skye N Fruean Fanny Gallardo-Arrieta Olga Glebova Rodrigo F Häfelin Manrique Joaquim JGP Henriques Natalia Ignatenko Debbie Koenig Marta Lanza-Perea Remo Lobetti Adriana M Lopez Quintana Thibault Losfelt Gabriele Marino Inigo Martincorena Simón Martínez Castañeda Mayra F Martínez-López Michael Meyer Berna Nakanwagi Andrigo B De Nardi Winifred Neunzig Sally J Nixon Marsden M Onsare Antonio Ortega-Pacheco Maria C Peleteiro Ruth J Pye John F Reece Jose Rojas Gutierrez Haleema Sadia Sheila K Schmeling Olga Shamanova Richard K Ssuna Audrey E Steenland-Smit Alla Svitich Ismail Thoya Ngoka Bogdan A Vițălaru Anna P de Vos Johan P de Vos Oliver Walkinton David C Wedge Alvaro S Wehrle-Martinez Mirjam G van der Wel Sophie AE Widdowson Elizabeth P Murchison |
| author_sort | Andrea Strakova |
| collection | DOAJ |
| description | Canine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution. |
| first_indexed | 2024-04-14T07:46:41Z |
| format | Article |
| id | doaj.art-06141372134c493a9c7fbb4ad68bc165 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:46:41Z |
| publishDate | 2016-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-06141372134c493a9c7fbb4ad68bc1652022-12-22T02:05:18ZengeLife Sciences Publications LtdeLife2050-084X2016-05-01510.7554/eLife.14552Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancerAndrea Strakova0Máire Ní Leathlobhair1Guo-Dong Wang2Ting-Ting Yin3Ilona Airikkala-Otter4Janice L Allen5Karen M Allum6Leontine Bansse-Issa7Jocelyn L Bisson8Artemio Castillo Domracheva9Karina F de Castro10Anne M Corrigan11Hugh R Cran12Jane T Crawford13Stephen M Cutter14Laura Delgadillo Keenan15Edward M Donelan16Ibikunle A Faramade17Erika Flores Reynoso18Eleni Fotopoulou19Skye N Fruean20Fanny Gallardo-Arrieta21Olga Glebova22Rodrigo F Häfelin Manrique23Joaquim JGP Henriques24Natalia Ignatenko25Debbie Koenig26Marta Lanza-Perea27Remo Lobetti28Adriana M Lopez Quintana29Thibault Losfelt30Gabriele Marino31Inigo Martincorena32Simón Martínez Castañeda33Mayra F Martínez-López34Michael Meyer35Berna Nakanwagi36Andrigo B De Nardi37Winifred Neunzig38Sally J Nixon39Marsden M Onsare40Antonio Ortega-Pacheco41Maria C Peleteiro42Ruth J Pye43John F Reece44Jose Rojas Gutierrez45Haleema Sadia46Sheila K Schmeling47Olga Shamanova48Richard K Ssuna49Audrey E Steenland-Smit50Alla Svitich51Ismail Thoya Ngoka52Bogdan A Vițălaru53Anna P de Vos54Johan P de Vos55Oliver Walkinton56David C Wedge57Alvaro S Wehrle-Martinez58Mirjam G van der Wel59Sophie AE Widdowson60Elizabeth P Murchison61https://orcid.org/0000-0001-7462-8907Department of Veterinary Medicine, University of Cambridge, Cambridge, United KingdomDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United KingdomState Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaState Key Laboratory of Genetic Resources and Evolution, Yunnan Laboratory of Molecular Biology of Domestic Animals, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, ChinaInternational Training Center, Worldwide Veterinary Service, Aruvankadu, IndiaAnimal Management in Rural and Remote Indigenous Communities, Darwin, AustraliaWorld Vets, Fargo, United StatesStichting Dierenbescherming Suriname, Paramaribo, SurinameDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United KingdomCorozal Veterinary Hospital, University of Panama, Panama City, PanamaDepartment of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, BrazilSt. George's University, True Blue, GrenadaThe Nakuru District Veterinary Scheme Ltd, Nakuru, KenyaAnimal Medical Centre, Belize City, BelizeAnimal Management in Rural and Remote Indigenous Communities, Darwin, AustraliaVeterinary clinic Sr. Dog's, Guadalajara, MexicoAnimal Management in Rural and Remote Indigenous Communities, Darwin, AustraliaNational Veterinary Research Institute, Vom, NigeriaInternational Fund for Animal Welfare, Quintana Roo, MexicoIntermunicipal Stray Animals Care Centre, Perama, GreeceAnimal Protection Society of Samoa, Apia, SamoaFaculty of Veterinary Science, University of Zulia, Maracaibo, VenezuelaVeterinary clinic BIOCONTROL, Moscow, RussiaVeterinary clinic El Roble, Santiago de Chile, ChileOnevetGroup, Centro Veterinário Berna, Lisboa, PortugalVeterinary clinic Zoovetservis, Kiev, UkraineWorld Vets, Fargo, United StatesSt. George's University, True Blue, GrenadaBryanston Veterinary Hospital, Bryanston, South AfricaVeterinary Clinic Lopez Quintana, Maldonado, UruguayClinique Veterinaire de Grand Fond, Saint Gilles les Bains, FranceDepartment of Veterinary Sciences, University of Messina, Messina, ItalyWellcome Trust Sanger Institute, Hinxton, United KingdomFacultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, MexicoSchool of Veterinary Medicine, Universidad de las Américas, Quito, EcuadorTouray & Meyer Vet Clinic, Serrekunda, GambiaThe Kampala Veterinary Surgery, Kampala, UgandaDepartment of Clinical and Veterinary Surgery, São Paulo State University, São Paulo, BrazilWorld Vets, Fargo, United StatesVets Beyond Borders, The Rocks, AustraliaAniworld veterinary clinic, Kisumu, KenyaFaculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, MexicoInterdisciplinary Centre of Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisboa, PortugalVets Beyond Borders, The Rocks, AustraliaHelp in Suffering, Jaipur, IndiaVeterinary clinic Dr José Rojas, Los Andes, ChileUniversity of Veterinary and Animal Sciences, Lahore, PakistanCorozal Veterinary Clinic, Corozal Town, BelizeVeterinary clinic Vetmaster, Ramenskoye, RussiaLilongwe Society for Protection and Care of Animals, Lilongwe, MalawiStichting Dierenbescherming Suriname, Paramaribo, SurinameState Hospital of Veterinary Medicine, Dniprodzerzhynsk, UkraineKenya Society for Protection and Care of Animals, Nairobi, KenyaClinical Sciences Department, Faculty of Veterinary Medicine, Bucharest, RomaniaLadybrand Animal Clinic, Ladybrand, South AfricaVeterinary Oncology Referral Centre De Ottenhorst, Terneuzen, NetherlandsVets Beyond Borders, The Rocks, AustraliaWellcome Trust Sanger Institute, Hinxton, United KingdomFaculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, ParaguayAnimal Anti Cruelty League, Port Elizabeth, South AfricaLilongwe Society for Protection and Care of Animals, Lilongwe, MalawiDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United KingdomCanine transmissible venereal tumour (CTVT) is a clonally transmissible cancer that originated approximately 11,000 years ago and affects dogs worldwide. Despite the clonal origin of the CTVT nuclear genome, CTVT mitochondrial genomes (mtDNAs) have been acquired by periodic capture from transient hosts. We sequenced 449 complete mtDNAs from a global population of CTVTs, and show that mtDNA horizontal transfer has occurred at least five times, delineating five tumour clades whose distributions track two millennia of dog global migration. Negative selection has operated to prevent accumulation of deleterious mutations in captured mtDNA, and recombination has caused occasional mtDNA re-assortment. These findings implicate functional mtDNA as a driver of CTVT global metastatic spread, further highlighting the important role of mtDNA in cancer evolution.https://elifesciences.org/articles/14552Dogtransmissible cancercanine transmissible venereal tumourmitochondria |
| spellingShingle | Andrea Strakova Máire Ní Leathlobhair Guo-Dong Wang Ting-Ting Yin Ilona Airikkala-Otter Janice L Allen Karen M Allum Leontine Bansse-Issa Jocelyn L Bisson Artemio Castillo Domracheva Karina F de Castro Anne M Corrigan Hugh R Cran Jane T Crawford Stephen M Cutter Laura Delgadillo Keenan Edward M Donelan Ibikunle A Faramade Erika Flores Reynoso Eleni Fotopoulou Skye N Fruean Fanny Gallardo-Arrieta Olga Glebova Rodrigo F Häfelin Manrique Joaquim JGP Henriques Natalia Ignatenko Debbie Koenig Marta Lanza-Perea Remo Lobetti Adriana M Lopez Quintana Thibault Losfelt Gabriele Marino Inigo Martincorena Simón Martínez Castañeda Mayra F Martínez-López Michael Meyer Berna Nakanwagi Andrigo B De Nardi Winifred Neunzig Sally J Nixon Marsden M Onsare Antonio Ortega-Pacheco Maria C Peleteiro Ruth J Pye John F Reece Jose Rojas Gutierrez Haleema Sadia Sheila K Schmeling Olga Shamanova Richard K Ssuna Audrey E Steenland-Smit Alla Svitich Ismail Thoya Ngoka Bogdan A Vițălaru Anna P de Vos Johan P de Vos Oliver Walkinton David C Wedge Alvaro S Wehrle-Martinez Mirjam G van der Wel Sophie AE Widdowson Elizabeth P Murchison Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer eLife Dog transmissible cancer canine transmissible venereal tumour mitochondria |
| title | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_full | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_fullStr | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_full_unstemmed | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_short | Mitochondrial genetic diversity, selection and recombination in a canine transmissible cancer |
| title_sort | mitochondrial genetic diversity selection and recombination in a canine transmissible cancer |
| topic | Dog transmissible cancer canine transmissible venereal tumour mitochondria |
| url | https://elifesciences.org/articles/14552 |
| work_keys_str_mv | AT andreastrakova mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT mairenileathlobhair mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT guodongwang mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT tingtingyin mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT ilonaairikkalaotter mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT janicelallen mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT karenmallum mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT leontinebansseissa mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT jocelynlbisson mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT artemiocastillodomracheva mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT karinafdecastro mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT annemcorrigan mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT hughrcran mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT janetcrawford mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT stephenmcutter mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT lauradelgadillokeenan mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT edwardmdonelan mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT ibikunleafaramade mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT erikafloresreynoso mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT elenifotopoulou mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT skyenfruean mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT fannygallardoarrieta mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT olgaglebova mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT rodrigofhafelinmanrique mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT joaquimjgphenriques mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT nataliaignatenko mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT debbiekoenig mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT martalanzaperea mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT remolobetti mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT adrianamlopezquintana mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT thibaultlosfelt mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT gabrielemarino mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT inigomartincorena mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT simonmartinezcastaneda mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT mayrafmartinezlopez mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT michaelmeyer mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT bernanakanwagi mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT andrigobdenardi mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT winifredneunzig mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT sallyjnixon mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT marsdenmonsare mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT antonioortegapacheco mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT mariacpeleteiro mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT ruthjpye mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT johnfreece mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT joserojasgutierrez mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT haleemasadia mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT sheilakschmeling mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT olgashamanova mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT richardkssuna mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT audreyesteenlandsmit mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT allasvitich mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT ismailthoyangoka mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT bogdanavitalaru mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT annapdevos mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT johanpdevos mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT oliverwalkinton mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT davidcwedge mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT alvaroswehrlemartinez mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT mirjamgvanderwel mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT sophieaewiddowson mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer AT elizabethpmurchison mitochondrialgeneticdiversityselectionandrecombinationinacaninetransmissiblecancer |