Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib
Modern therapy for rheumatoid arthritis (RA) allows not only to reduce the activity of immune-mediated inflammation and slow down the progression of the disease, but also to quickly eliminate the main symptoms that cause the most concern to patients, such as pain, functional disorders, fatigue. This...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2020-09-01
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| Series: | Научно-практическая ревматология |
| Subjects: | |
| Online Access: | https://rsp.mediar-press.net/rsp/article/view/2931 |
| _version_ | 1797862557523902464 |
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| author | A. E. Karateev |
| author_facet | A. E. Karateev |
| author_sort | A. E. Karateev |
| collection | DOAJ |
| description | Modern therapy for rheumatoid arthritis (RA) allows not only to reduce the activity of immune-mediated inflammation and slow down the progression of the disease, but also to quickly eliminate the main symptoms that cause the most concern to patients, such as pain, functional disorders, fatigue. This action has an inhibitor of Janus kinases 1/ 2 – baricitinib, which quickly reduces the activity of inflammation, provides remission in RA, and has a high analgesic effect. The review discusses the role of autoimmune inflammation and the intracellular signaling pathway JAK/STAT (Janus kinase/signal transducers and activators of transcription) in the pathogenesis of chronic pain in RA, the role of baricitinib for effective control of pain intensity and fatigue. |
| first_indexed | 2024-04-09T22:22:23Z |
| format | Article |
| id | doaj.art-061439e61097470cb40aaded40029790 |
| institution | Directory Open Access Journal |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| last_indexed | 2024-04-09T22:22:23Z |
| publishDate | 2020-09-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj.art-061439e61097470cb40aaded400297902023-03-22T13:45:56ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922020-09-0158442042710.47360/1995-4484-2020-420-4272635Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinibA. E. Karateev0V.A. Nasonova Research Institute of RheumatologyModern therapy for rheumatoid arthritis (RA) allows not only to reduce the activity of immune-mediated inflammation and slow down the progression of the disease, but also to quickly eliminate the main symptoms that cause the most concern to patients, such as pain, functional disorders, fatigue. This action has an inhibitor of Janus kinases 1/ 2 – baricitinib, which quickly reduces the activity of inflammation, provides remission in RA, and has a high analgesic effect. The review discusses the role of autoimmune inflammation and the intracellular signaling pathway JAK/STAT (Janus kinase/signal transducers and activators of transcription) in the pathogenesis of chronic pain in RA, the role of baricitinib for effective control of pain intensity and fatigue.https://rsp.mediar-press.net/rsp/article/view/2931rheumatoid arthritischronic painfatiguetargeted synthetic basic anti-inflammatory drugsjak kinasebaricitinib |
| spellingShingle | A. E. Karateev Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib Научно-практическая ревматология rheumatoid arthritis chronic pain fatigue targeted synthetic basic anti-inflammatory drugs jak kinase baricitinib |
| title | Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib |
| title_full | Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib |
| title_fullStr | Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib |
| title_full_unstemmed | Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib |
| title_short | Problems of pain and quality of life in rheumatoid arthritis: focus on baricitinib |
| title_sort | problems of pain and quality of life in rheumatoid arthritis focus on baricitinib |
| topic | rheumatoid arthritis chronic pain fatigue targeted synthetic basic anti-inflammatory drugs jak kinase baricitinib |
| url | https://rsp.mediar-press.net/rsp/article/view/2931 |
| work_keys_str_mv | AT aekarateev problemsofpainandqualityoflifeinrheumatoidarthritisfocusonbaricitinib |