Item-specific neural representations during human sleep support long-term memory.
Understanding how individual memories are reactivated during sleep is essential in theorizing memory consolidation. Here, we employed the targeted memory reactivation (TMR) paradigm to unobtrusively replaying auditory memory cues during human participants' slow-wave sleep (SWS). Using represent...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-11-01
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| Series: | PLoS Biology |
| Online Access: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002399&type=printable |
| _version_ | 1797392906119544832 |
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| author | Jing Liu Tao Xia Danni Chen Ziqing Yao Minrui Zhu James W Antony Tatia M C Lee Xiaoqing Hu |
| author_facet | Jing Liu Tao Xia Danni Chen Ziqing Yao Minrui Zhu James W Antony Tatia M C Lee Xiaoqing Hu |
| author_sort | Jing Liu |
| collection | DOAJ |
| description | Understanding how individual memories are reactivated during sleep is essential in theorizing memory consolidation. Here, we employed the targeted memory reactivation (TMR) paradigm to unobtrusively replaying auditory memory cues during human participants' slow-wave sleep (SWS). Using representational similarity analysis (RSA) on cue-elicited electroencephalogram (EEG), we found temporally segregated and functionally distinct item-specific neural representations: the early post-cue EEG activity (within 0 to 2,000 ms) contained comparable item-specific representations for memory cues and control cues, signifying effective processing of auditory cues. Critically, the later EEG activity (2,500 to 2,960 ms) showed greater item-specific representations for post-sleep remembered items than for forgotten and control cues, indicating memory reprocessing. Moreover, these later item-specific neural representations were supported by concurrently increased spindles, particularly for items that had not been tested prior to sleep. These findings elucidated how external memory cues triggered item-specific neural representations during SWS and how such representations were linked to successful long-term memory. These results will benefit future research aiming to perturb specific memory episodes during sleep. |
| first_indexed | 2024-03-08T23:55:22Z |
| format | Article |
| id | doaj.art-0615568bcf264802b703c99ac6f0c24b |
| institution | Directory Open Access Journal |
| issn | 1544-9173 1545-7885 |
| language | English |
| last_indexed | 2024-03-08T23:55:22Z |
| publishDate | 2023-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj.art-0615568bcf264802b703c99ac6f0c24b2023-12-13T05:31:19ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852023-11-012111e300239910.1371/journal.pbio.3002399Item-specific neural representations during human sleep support long-term memory.Jing LiuTao XiaDanni ChenZiqing YaoMinrui ZhuJames W AntonyTatia M C LeeXiaoqing HuUnderstanding how individual memories are reactivated during sleep is essential in theorizing memory consolidation. Here, we employed the targeted memory reactivation (TMR) paradigm to unobtrusively replaying auditory memory cues during human participants' slow-wave sleep (SWS). Using representational similarity analysis (RSA) on cue-elicited electroencephalogram (EEG), we found temporally segregated and functionally distinct item-specific neural representations: the early post-cue EEG activity (within 0 to 2,000 ms) contained comparable item-specific representations for memory cues and control cues, signifying effective processing of auditory cues. Critically, the later EEG activity (2,500 to 2,960 ms) showed greater item-specific representations for post-sleep remembered items than for forgotten and control cues, indicating memory reprocessing. Moreover, these later item-specific neural representations were supported by concurrently increased spindles, particularly for items that had not been tested prior to sleep. These findings elucidated how external memory cues triggered item-specific neural representations during SWS and how such representations were linked to successful long-term memory. These results will benefit future research aiming to perturb specific memory episodes during sleep.https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002399&type=printable |
| spellingShingle | Jing Liu Tao Xia Danni Chen Ziqing Yao Minrui Zhu James W Antony Tatia M C Lee Xiaoqing Hu Item-specific neural representations during human sleep support long-term memory. PLoS Biology |
| title | Item-specific neural representations during human sleep support long-term memory. |
| title_full | Item-specific neural representations during human sleep support long-term memory. |
| title_fullStr | Item-specific neural representations during human sleep support long-term memory. |
| title_full_unstemmed | Item-specific neural representations during human sleep support long-term memory. |
| title_short | Item-specific neural representations during human sleep support long-term memory. |
| title_sort | item specific neural representations during human sleep support long term memory |
| url | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.3002399&type=printable |
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