MiR-223 suppresses cell proliferation by targeting IGF-1R.

MiR-223 suppresses cell proliferation by targeting IGF-1R.

To study the roles of microRNA-223 (miR-223) in regulation of cell growth, we established a miR-223 over-expression model in HeLa cells infected with miR-223 by Lentivirus pLL3.7 system. We observed in this model that miR-223 significantly suppressed the proliferation, growth rate, colony formation...

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Bibliographic Details
Main Authors: Cheng You Jia, Hui Hui Li, Xu Chao Zhu, Yi Wei Dong, Da Fu, Qian Lei Zhao, Wei Wu, Xing Zhong Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3206888?pdf=render

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