CPEB3 is associated with human episodic memory
Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans the ribozyme sequence...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2009-05-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/neuro.08.004.2009/full |
| _version_ | 1818154993751949312 |
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| author | Christian Vogler Christian Vogler Klara Spalek Klara Spalek Amanda Aerni Philippe Demougin Philippe Demougin Ariane Müller Ariane Müller Kim-Dung Huynh Kim-Dung Huynh Andreas Papassotiropoul Andreas Papassotiropoul Dominique J F De Quervain Dominique J F De Quervain |
| author_facet | Christian Vogler Christian Vogler Klara Spalek Klara Spalek Amanda Aerni Philippe Demougin Philippe Demougin Ariane Müller Ariane Müller Kim-Dung Huynh Kim-Dung Huynh Andreas Papassotiropoul Andreas Papassotiropoul Dominique J F De Quervain Dominique J F De Quervain |
| author_sort | Christian Vogler |
| collection | DOAJ |
| description | Cytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism which influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data support a role for human CPEB3 in human episodic memory. |
| first_indexed | 2024-12-11T14:35:20Z |
| format | Article |
| id | doaj.art-061565c227134b149f792232ba808619 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-11T14:35:20Z |
| publishDate | 2009-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-061565c227134b149f792232ba8086192022-12-22T01:02:12ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532009-05-01310.3389/neuro.08.004.2009464CPEB3 is associated with human episodic memoryChristian Vogler0Christian Vogler1Klara Spalek2Klara Spalek3Amanda Aerni4Philippe Demougin5Philippe Demougin6Ariane Müller7Ariane Müller8Kim-Dung Huynh9Kim-Dung Huynh10Andreas Papassotiropoul11Andreas Papassotiropoul12Dominique J F De Quervain13Dominique J F De Quervain14University of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of ZurichUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of BaselUniversity of ZurichUniversity of ZurichCytoplasmic polyadenylation element-binding (CPEB) proteins are crucial for synaptic plasticity and memory in model organisms. A highly conserved, mammalian-specific short intronic sequence within CPEB3 has been identified as a ribozyme with self-cleavage properties. In humans the ribozyme sequence is polymorphic and harbors a single nucleotide polymorphism which influences cleavage activity of the ribozyme. Here we show that this variation is related to performance in an episodic memory task and that the effect of the variation depends on the emotional valence of the presented material. Our data support a role for human CPEB3 in human episodic memory.http://journal.frontiersin.org/Journal/10.3389/neuro.08.004.2009/fullMemoryepisodicemotionalpolymorphismCPEB3 |
| spellingShingle | Christian Vogler Christian Vogler Klara Spalek Klara Spalek Amanda Aerni Philippe Demougin Philippe Demougin Ariane Müller Ariane Müller Kim-Dung Huynh Kim-Dung Huynh Andreas Papassotiropoul Andreas Papassotiropoul Dominique J F De Quervain Dominique J F De Quervain CPEB3 is associated with human episodic memory Frontiers in Behavioral Neuroscience Memory episodic emotional polymorphism CPEB3 |
| title | CPEB3 is associated with human episodic memory |
| title_full | CPEB3 is associated with human episodic memory |
| title_fullStr | CPEB3 is associated with human episodic memory |
| title_full_unstemmed | CPEB3 is associated with human episodic memory |
| title_short | CPEB3 is associated with human episodic memory |
| title_sort | cpeb3 is associated with human episodic memory |
| topic | Memory episodic emotional polymorphism CPEB3 |
| url | http://journal.frontiersin.org/Journal/10.3389/neuro.08.004.2009/full |
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