A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae
Whole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle.
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-03-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-08903-w |
| _version_ | 1818342138683850752 |
|---|---|
| author | Ulrike Münzner Edda Klipp Marcus Krantz |
| author_facet | Ulrike Münzner Edda Klipp Marcus Krantz |
| author_sort | Ulrike Münzner |
| collection | DOAJ |
| description | Whole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle. |
| first_indexed | 2024-12-13T16:09:56Z |
| format | Article |
| id | doaj.art-0615cfea666e4b4e822c127ef0947045 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:09:56Z |
| publishDate | 2019-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0615cfea666e4b4e822c127ef09470452022-12-21T23:38:58ZengNature PortfolioNature Communications2041-17232019-03-0110111210.1038/s41467-019-08903-wA comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiaeUlrike Münzner0Edda Klipp1Marcus Krantz2Humboldt-Universität zu Berlin, Institute of Biology, Theoretical BiophysicsHumboldt-Universität zu Berlin, Institute of Biology, Theoretical BiophysicsHumboldt-Universität zu Berlin, Institute of Biology, Theoretical BiophysicsWhole-cell models hold great promise for fundamental and translational biology, but genome-scale modelling of signalling networks has been a challenge. Here, the authors present a genome-scale, mechanistic and executable model of the network controlling and executing the S. cerevisiae cell cycle.https://doi.org/10.1038/s41467-019-08903-w |
| spellingShingle | Ulrike Münzner Edda Klipp Marcus Krantz A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae Nature Communications |
| title | A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae |
| title_full | A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae |
| title_fullStr | A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae |
| title_full_unstemmed | A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae |
| title_short | A comprehensive, mechanistically detailed, and executable model of the cell division cycle in Saccharomyces cerevisiae |
| title_sort | comprehensive mechanistically detailed and executable model of the cell division cycle in saccharomyces cerevisiae |
| url | https://doi.org/10.1038/s41467-019-08903-w |
| work_keys_str_mv | AT ulrikemunzner acomprehensivemechanisticallydetailedandexecutablemodelofthecelldivisioncycleinsaccharomycescerevisiae AT eddaklipp acomprehensivemechanisticallydetailedandexecutablemodelofthecelldivisioncycleinsaccharomycescerevisiae AT marcuskrantz acomprehensivemechanisticallydetailedandexecutablemodelofthecelldivisioncycleinsaccharomycescerevisiae AT ulrikemunzner comprehensivemechanisticallydetailedandexecutablemodelofthecelldivisioncycleinsaccharomycescerevisiae AT eddaklipp comprehensivemechanisticallydetailedandexecutablemodelofthecelldivisioncycleinsaccharomycescerevisiae AT marcuskrantz comprehensivemechanisticallydetailedandexecutablemodelofthecelldivisioncycleinsaccharomycescerevisiae |