Immunotherapy with NK cells: recent developments in gene modification open up new avenues
Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual kill...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-01-01
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| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/2162402X.2020.1777651 |
| _version_ | 1819133915745484800 |
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| author | Lisa Marie Reindl Nawid Albinger Tobias Bexte Stephan Müller Jessica Hartmann Evelyn Ullrich |
| author_facet | Lisa Marie Reindl Nawid Albinger Tobias Bexte Stephan Müller Jessica Hartmann Evelyn Ullrich |
| author_sort | Lisa Marie Reindl |
| collection | DOAJ |
| description | Chimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential. |
| first_indexed | 2024-12-22T09:54:53Z |
| format | Article |
| id | doaj.art-0616bc6e29da4671903ffed3e39bb6d7 |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-12-22T09:54:53Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-0616bc6e29da4671903ffed3e39bb6d72022-12-21T18:30:18ZengTaylor & Francis GroupOncoImmunology2162-402X2020-01-019110.1080/2162402X.2020.17776511777651Immunotherapy with NK cells: recent developments in gene modification open up new avenuesLisa Marie Reindl0Nawid Albinger1Tobias Bexte2Stephan Müller3Jessica Hartmann4Evelyn Ullrich5Goethe-University FrankfurtGoethe-University FrankfurtGoethe-University FrankfurtGoethe-University FrankfurtPaul-Ehrlich-InstituteGoethe-University FrankfurtChimeric antigen receptor (CAR)-T cell therapies have achieved remarkable success. However, application-related toxicities, such as cytokine release syndrome or neurotoxicity, moved natural killer (NK) cells into focus as novel players in immunotherapy. CAR-NK cells provide an advantageous dual killing-capacity by CAR-dependent and -independent mechanisms and induce few side effects. While the majority of trials still use CAR-T cells, CAR-NK cell trials are on the rise with 19 ongoing studies worldwide. This review illuminates the current state of research and clinical application of CAR-NK cells, as well as future developmental potential.http://dx.doi.org/10.1080/2162402X.2020.1777651carnk cellsnk-92 cellscell therapy |
| spellingShingle | Lisa Marie Reindl Nawid Albinger Tobias Bexte Stephan Müller Jessica Hartmann Evelyn Ullrich Immunotherapy with NK cells: recent developments in gene modification open up new avenues OncoImmunology car nk cells nk-92 cells cell therapy |
| title | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
| title_full | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
| title_fullStr | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
| title_full_unstemmed | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
| title_short | Immunotherapy with NK cells: recent developments in gene modification open up new avenues |
| title_sort | immunotherapy with nk cells recent developments in gene modification open up new avenues |
| topic | car nk cells nk-92 cells cell therapy |
| url | http://dx.doi.org/10.1080/2162402X.2020.1777651 |
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