A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics
Cardiovascular diseases (CVD) are the major health issue of modernized society with a high mortality rate. Lifestyle, genetic makeup, and diet are some of the major influencing factors associated with CVD. The dyslipidemia is one such factor related to the development of several CVD. Many studies pr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-10-01
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| Series: | Scientia Pharmaceutica |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-0532/87/4/26 |
| _version_ | 1828357832438710272 |
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| author | Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Chaiyavat Chaiyasut |
| author_facet | Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Chaiyavat Chaiyasut |
| author_sort | Bhagavathi Sundaram Sivamaruthi |
| collection | DOAJ |
| description | Cardiovascular diseases (CVD) are the major health issue of modernized society with a high mortality rate. Lifestyle, genetic makeup, and diet are some of the major influencing factors associated with CVD. The dyslipidemia is one such factor related to the development of several CVD. Many studies proved that the consumption of probiotics confers several health benefits. Several studies reported the evaluation of the cholesterol-lowering ability of probiotics (probiotics that showed positive effect in vitro and in vivo studies) in human volunteers. The current review summarizes the outcomes of human studies on the cholesterol-lowering property of probiotics. Probiotic consumption significantly improved the health status of hypercholesteremic patients by reducing the low-density lipoprotein cholesterol, total cholesterol, triglyceride levels, and increased the high-density lipoprotein cholesterol. The probiotic supplementation improved the lipid profile of diabetic patients, and obese people as well. However, not all probiotic interventions are effective against dyslipidemia. The results are controversial and depend on several factors such as probiotic strain, dose, duration of the treatment, lifestyle changes, etc. This literature survey indorses additional studies on the cholesterol-lowering property of probiotics, which could help to reduce the risk of CVD and other dyslipidemia associated health issues. |
| first_indexed | 2024-04-14T03:21:23Z |
| format | Article |
| id | doaj.art-06173a8ade0d4b96844ec3e881d70af3 |
| institution | Directory Open Access Journal |
| issn | 2218-0532 |
| language | English |
| last_indexed | 2024-04-14T03:21:23Z |
| publishDate | 2019-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Scientia Pharmaceutica |
| spelling | doaj.art-06173a8ade0d4b96844ec3e881d70af32022-12-22T02:15:18ZengMDPI AGScientia Pharmaceutica2218-05322019-10-018742610.3390/scipharm87040026scipharm87040026A Mini-Review of Human Studies on Cholesterol-Lowering Properties of ProbioticsBhagavathi Sundaram Sivamaruthi0Periyanaina Kesika1Chaiyavat Chaiyasut2Innovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Chiang Mai University, Chiang Mai-50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Chiang Mai University, Chiang Mai-50200, ThailandInnovation Center for Holistic Health, Nutraceuticals, and Cosmeceuticals, Chiang Mai University, Chiang Mai-50200, ThailandCardiovascular diseases (CVD) are the major health issue of modernized society with a high mortality rate. Lifestyle, genetic makeup, and diet are some of the major influencing factors associated with CVD. The dyslipidemia is one such factor related to the development of several CVD. Many studies proved that the consumption of probiotics confers several health benefits. Several studies reported the evaluation of the cholesterol-lowering ability of probiotics (probiotics that showed positive effect in vitro and in vivo studies) in human volunteers. The current review summarizes the outcomes of human studies on the cholesterol-lowering property of probiotics. Probiotic consumption significantly improved the health status of hypercholesteremic patients by reducing the low-density lipoprotein cholesterol, total cholesterol, triglyceride levels, and increased the high-density lipoprotein cholesterol. The probiotic supplementation improved the lipid profile of diabetic patients, and obese people as well. However, not all probiotic interventions are effective against dyslipidemia. The results are controversial and depend on several factors such as probiotic strain, dose, duration of the treatment, lifestyle changes, etc. This literature survey indorses additional studies on the cholesterol-lowering property of probiotics, which could help to reduce the risk of CVD and other dyslipidemia associated health issues.https://www.mdpi.com/2218-0532/87/4/26probioticshypocholesteremiacardiovascular diseasescholesterol-lowering lipidsmicrobiota |
| spellingShingle | Bhagavathi Sundaram Sivamaruthi Periyanaina Kesika Chaiyavat Chaiyasut A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics Scientia Pharmaceutica probiotics hypocholesteremia cardiovascular diseases cholesterol-lowering lipids microbiota |
| title | A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics |
| title_full | A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics |
| title_fullStr | A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics |
| title_full_unstemmed | A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics |
| title_short | A Mini-Review of Human Studies on Cholesterol-Lowering Properties of Probiotics |
| title_sort | mini review of human studies on cholesterol lowering properties of probiotics |
| topic | probiotics hypocholesteremia cardiovascular diseases cholesterol-lowering lipids microbiota |
| url | https://www.mdpi.com/2218-0532/87/4/26 |
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