Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project
<p><strong>Objective:</strong> The primary objective of this study was to identify adverse events associated with multiple intra-articular injections of adipose stromal cell (ASC) therapy and secondarily to objectively assess the therapeutic effect of ASC therapy for treatment of f...
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| Format: | Article |
| Language: | English |
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RCVS Knowledge
2016-11-01
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| Series: | Veterinary Evidence |
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| Online Access: | https://veterinaryevidence.org/index.php/ve/article/view/45 |
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| author | Kristina M Kiefer Katja Lin Noel Fitzpatrick Elizabeth Pluhar Michael G. Conzemius |
| author_facet | Kristina M Kiefer Katja Lin Noel Fitzpatrick Elizabeth Pluhar Michael G. Conzemius |
| author_sort | Kristina M Kiefer |
| collection | DOAJ |
| description | <p><strong>Objective:</strong> The primary objective of this study was to identify adverse events associated with multiple intra-articular injections of adipose stromal cell (ASC) therapy and secondarily to objectively assess the therapeutic effect of ASC therapy for treatment of fragmented medial coronoid process (FMCP) in dogs when used as an adjuvant to standard of care (SOC) treatment. </p><p><strong>Background:</strong> Preliminary trials assessing autologous ASC therapy to treat osteoarthritis indicate a positive impact on clinical signs, but assessment of donated, allogeneic ASC therapy is lacking.</p><p><strong>Evidentiary value:</strong> This prospective, randomised, controlled trial in dogs (n=30) provides objective evidence for clinical practitioners regarding ASC therapy in a naturally occurring osteoarthritic disease model.</p><p><strong>Methods: </strong>Dogs diagnosed with FMCP and osteoarthritis were enrolled. All dogs had arthroscopic fragment removal and proximal ulnar osteotomy (PUO) and were assigned into three groups (n=10/group): 1) control group with no further treatment beyond the PUO and fragment removal (SOC), 2) PUO + autologous ASCs and 3) PUO+ allogeneic ASCs. Each dog had force platform gait analysis, Canine Brief Pain Inventory (CBPI) questionnaires, and delayed gadolinium enhanced magnetic resonance imaging scores prior to and six months after therapeutic intervention.</p><p><strong>Results:</strong> No serious adverse events were reported in any participant. 3/10 dogs in the control group, 3/10 autologous ASC group and 7/10 allogeneic ASC group participants were assessed as successful outcomes.</p><p><strong>Conclusion: </strong>This study provides preliminary safety data for the use of intra-articular allogeneic ASC therapy to treat osteoarthritis, and justification for larger clinical studies.</p><p><strong>Application:</strong> Clinical practitioners considering ASC therapy within their practice are provided with additional evidence of autologous ASC therapy for osteoarthritis. Researchers committed to developing and generating effective ASC therapies are provided with safety information for allogeneic ASC, as well as identified biases important for study design.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" /> |
| first_indexed | 2024-12-11T07:50:06Z |
| format | Article |
| id | doaj.art-06191daf3a464eb4b07c57628ea9256e |
| institution | Directory Open Access Journal |
| issn | 2396-9776 |
| language | English |
| last_indexed | 2024-12-11T07:50:06Z |
| publishDate | 2016-11-01 |
| publisher | RCVS Knowledge |
| record_format | Article |
| series | Veterinary Evidence |
| spelling | doaj.art-06191daf3a464eb4b07c57628ea9256e2022-12-22T01:15:22ZengRCVS KnowledgeVeterinary Evidence2396-97762016-11-011410.18849/ve.v1i4.4535Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot ProjectKristina M Kiefer0Katja Lin1Noel Fitzpatrick2Elizabeth Pluhar3Michael G. Conzemius4University of Minnesota, College of Veterinary Medicine, Veterinary Clinical Sciences 1352 Boyd Ave, St. Paul MN 55108Las Vegas Veterinary Specialty Center 8650 W. Tropicana Avenue, Ste. B-107, Las Vegas, NV 89147Fitzpatrick Referrals Halfway Ln, Eashing, Godalming, Surrey GU7 2QQ, United KingdomUniversity of Minnesota, College of Veterinary Medicine, Veterinary Clinical Sciences 1352 Boyd Ave, St. Paul MN 55108University of Minnesota, College of Veterinary Medicine, Veterinary Clinical Sciences 1352 Boyd Ave, St. Paul MN 55108<p><strong>Objective:</strong> The primary objective of this study was to identify adverse events associated with multiple intra-articular injections of adipose stromal cell (ASC) therapy and secondarily to objectively assess the therapeutic effect of ASC therapy for treatment of fragmented medial coronoid process (FMCP) in dogs when used as an adjuvant to standard of care (SOC) treatment. </p><p><strong>Background:</strong> Preliminary trials assessing autologous ASC therapy to treat osteoarthritis indicate a positive impact on clinical signs, but assessment of donated, allogeneic ASC therapy is lacking.</p><p><strong>Evidentiary value:</strong> This prospective, randomised, controlled trial in dogs (n=30) provides objective evidence for clinical practitioners regarding ASC therapy in a naturally occurring osteoarthritic disease model.</p><p><strong>Methods: </strong>Dogs diagnosed with FMCP and osteoarthritis were enrolled. All dogs had arthroscopic fragment removal and proximal ulnar osteotomy (PUO) and were assigned into three groups (n=10/group): 1) control group with no further treatment beyond the PUO and fragment removal (SOC), 2) PUO + autologous ASCs and 3) PUO+ allogeneic ASCs. Each dog had force platform gait analysis, Canine Brief Pain Inventory (CBPI) questionnaires, and delayed gadolinium enhanced magnetic resonance imaging scores prior to and six months after therapeutic intervention.</p><p><strong>Results:</strong> No serious adverse events were reported in any participant. 3/10 dogs in the control group, 3/10 autologous ASC group and 7/10 allogeneic ASC group participants were assessed as successful outcomes.</p><p><strong>Conclusion: </strong>This study provides preliminary safety data for the use of intra-articular allogeneic ASC therapy to treat osteoarthritis, and justification for larger clinical studies.</p><p><strong>Application:</strong> Clinical practitioners considering ASC therapy within their practice are provided with additional evidence of autologous ASC therapy for osteoarthritis. Researchers committed to developing and generating effective ASC therapies are provided with safety information for allogeneic ASC, as well as identified biases important for study design.</p><br /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access" /> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed" />https://veterinaryevidence.org/index.php/ve/article/view/45stem cellsfragmented coronoid processosteoarthritiscanine |
| spellingShingle | Kristina M Kiefer Katja Lin Noel Fitzpatrick Elizabeth Pluhar Michael G. Conzemius Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project Veterinary Evidence stem cells fragmented coronoid process osteoarthritis canine |
| title | Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project |
| title_full | Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project |
| title_fullStr | Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project |
| title_full_unstemmed | Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project |
| title_short | Does Adipose-derived Stromal Cell Adjuvant Therapy for Fragmented Medial Coronoid Process in Dogs Influence Outcome? A Pilot Project |
| title_sort | does adipose derived stromal cell adjuvant therapy for fragmented medial coronoid process in dogs influence outcome a pilot project |
| topic | stem cells fragmented coronoid process osteoarthritis canine |
| url | https://veterinaryevidence.org/index.php/ve/article/view/45 |
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