The role of breast cancer molecular subtypes in axillary lymph node positivity
Breast cancer is a complex disease with various histopathological and molecular features. We aimed to investigate the clinicopathological predictor factors, especially molecular sub-types, on axillary involvement in breast cancer patients. Female patients who underwent mastectomy or breast-conservin...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2023-06-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | https://www.medicinescience.org/?mno=145666 |
| _version_ | 1797316431175483392 |
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| author | Mehmet Aslan Abdullah Gunes |
| author_facet | Mehmet Aslan Abdullah Gunes |
| author_sort | Mehmet Aslan |
| collection | DOAJ |
| description | Breast cancer is a complex disease with various histopathological and molecular features. We aimed to investigate the clinicopathological predictor factors, especially molecular sub-types, on axillary involvement in breast cancer patients. Female patients who underwent mastectomy or breast-conserving surgery combined with sentinel lymph node biopsy or axillary dissection were included in this study. Clinicopathological features including age, tumor location, lymphovascular invasion, perineural invasion, grade, tumor size, and hormonal receptor status were recorded. The cohort consisted of 238 patients. The mean age of the participants was 55.24±11.52 years. The most common molecular sub-type was Luminal B HER2- with 30.3%. This sub-type was followed by Triple-Negative (22.7%), Luminal A (18.9%), non-Luminal HER2+ (16.4%), and Luminal B HER2+ (11.8%), respectively. There was a significant relationship between the tumor sub-type and the axillary involvement (p=0.003). Axillary lymph node metastases were less common in Luminal A and Triple-Negative tumors. In luminal A sub-type, axillary involvement was the lowest with a rate of 24.4% (OR=0.260, 95%Cl: 0.124-0.543, p [Med-Science 2023; 12(2.000): 490-4] |
| first_indexed | 2024-03-08T03:19:16Z |
| format | Article |
| id | doaj.art-0619acaaf13049bc89aa78c3eedbda8c |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T03:19:16Z |
| publishDate | 2023-06-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-0619acaaf13049bc89aa78c3eedbda8c2024-02-12T10:33:28ZengSociety of Turaz BilimMedicine Science2147-06342023-06-01122490410.5455/medscience.2023.03.038145666The role of breast cancer molecular subtypes in axillary lymph node positivityMehmet Aslan0Abdullah Gunes1MedicalPark Kocaeli Hospital SBU Derince Training and Research HospitalBreast cancer is a complex disease with various histopathological and molecular features. We aimed to investigate the clinicopathological predictor factors, especially molecular sub-types, on axillary involvement in breast cancer patients. Female patients who underwent mastectomy or breast-conserving surgery combined with sentinel lymph node biopsy or axillary dissection were included in this study. Clinicopathological features including age, tumor location, lymphovascular invasion, perineural invasion, grade, tumor size, and hormonal receptor status were recorded. The cohort consisted of 238 patients. The mean age of the participants was 55.24±11.52 years. The most common molecular sub-type was Luminal B HER2- with 30.3%. This sub-type was followed by Triple-Negative (22.7%), Luminal A (18.9%), non-Luminal HER2+ (16.4%), and Luminal B HER2+ (11.8%), respectively. There was a significant relationship between the tumor sub-type and the axillary involvement (p=0.003). Axillary lymph node metastases were less common in Luminal A and Triple-Negative tumors. In luminal A sub-type, axillary involvement was the lowest with a rate of 24.4% (OR=0.260, 95%Cl: 0.124-0.543, p [Med-Science 2023; 12(2.000): 490-4]https://www.medicinescience.org/?mno=145666breast cancermolecular sub-typeshormonal receptor status |
| spellingShingle | Mehmet Aslan Abdullah Gunes The role of breast cancer molecular subtypes in axillary lymph node positivity Medicine Science breast cancer molecular sub-types hormonal receptor status |
| title | The role of breast cancer molecular subtypes in axillary lymph node positivity |
| title_full | The role of breast cancer molecular subtypes in axillary lymph node positivity |
| title_fullStr | The role of breast cancer molecular subtypes in axillary lymph node positivity |
| title_full_unstemmed | The role of breast cancer molecular subtypes in axillary lymph node positivity |
| title_short | The role of breast cancer molecular subtypes in axillary lymph node positivity |
| title_sort | role of breast cancer molecular subtypes in axillary lymph node positivity |
| topic | breast cancer molecular sub-types hormonal receptor status |
| url | https://www.medicinescience.org/?mno=145666 |
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