Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic Review
Parsonage-Turner syndrome (PTS) is an inflammatory disorder of the brachial plexus. Hypothesized underlying causes focus on immune-mediated processes, as more than half of patients present some antecedent event or possible predisposing condition, such as infection, vaccination, exercise, or surgery....
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| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/837 |
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| author | Amalia Cornea Irina Lata Mihaela Simu Elena Cecilia Rosca |
| author_facet | Amalia Cornea Irina Lata Mihaela Simu Elena Cecilia Rosca |
| author_sort | Amalia Cornea |
| collection | DOAJ |
| description | Parsonage-Turner syndrome (PTS) is an inflammatory disorder of the brachial plexus. Hypothesized underlying causes focus on immune-mediated processes, as more than half of patients present some antecedent event or possible predisposing condition, such as infection, vaccination, exercise, or surgery. Recently, PTS was reported following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate data on PTS triggered by SARS-CoV-2 infection to provide an extensive perspective on this pathology and to reveal what other, more specific, research questions can be further addressed. In addition, we aimed to highlight research gaps requiring further attention. We systematically reviewed two databases (LitCOVID and the World Health Organization database on COVID-19) to January 2023. We found 26 cases of PTS in patients with previous SARS-CoV-2 infection. The clinical and paraclinical spectrum was heterogeneous, ranging from classical PTS to pure sensory neuropathy, extended neuropathy, spinal accessory nerve involvement, and diaphragmatic palsy. Also, two familial cases were reported. Among them, 93.8% of patients had severe pain, 80.8% were reported to present a motor deficit, and 53.8% of patients presented muscle wasting. Paresthesia was noted in 46.2% of PTS individuals and a sensory loss was reported in 34.6% of patients. The present systematic review highlights the necessity of having a high index of suspicion of PTS in patients with previous SARS-CoV-2 infection, as the clinical manifestations can be variable. Also, there is a need for a standardized approach to investigation and reporting on PTS. Future studies should aim for a comprehensive assessment of patients. Factors including the baseline characteristics of the patients, evolution, and treatments should be consistently assessed across studies. In addition, a thorough differential diagnosis should be employed. |
| first_indexed | 2024-03-11T06:53:10Z |
| format | Article |
| id | doaj.art-0619eb1aad0045109d480ca8d61c43bb |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:10Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0619eb1aad0045109d480ca8d61c43bb2023-11-17T09:46:20ZengMDPI AGBiomedicines2227-90592023-03-0111383710.3390/biomedicines11030837Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic ReviewAmalia Cornea0Irina Lata1Mihaela Simu2Elena Cecilia Rosca3Department of Neurology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, RomaniaDepartment of Neurology, Clinical Emergency County Hospital Timisoara, Bd. Iosif Bulbuca no. 10, 300736 Timisoara, RomaniaDepartment of Neurology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, RomaniaDepartment of Neurology, Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. no. 2, 300041 Timisoara, RomaniaParsonage-Turner syndrome (PTS) is an inflammatory disorder of the brachial plexus. Hypothesized underlying causes focus on immune-mediated processes, as more than half of patients present some antecedent event or possible predisposing condition, such as infection, vaccination, exercise, or surgery. Recently, PTS was reported following the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate data on PTS triggered by SARS-CoV-2 infection to provide an extensive perspective on this pathology and to reveal what other, more specific, research questions can be further addressed. In addition, we aimed to highlight research gaps requiring further attention. We systematically reviewed two databases (LitCOVID and the World Health Organization database on COVID-19) to January 2023. We found 26 cases of PTS in patients with previous SARS-CoV-2 infection. The clinical and paraclinical spectrum was heterogeneous, ranging from classical PTS to pure sensory neuropathy, extended neuropathy, spinal accessory nerve involvement, and diaphragmatic palsy. Also, two familial cases were reported. Among them, 93.8% of patients had severe pain, 80.8% were reported to present a motor deficit, and 53.8% of patients presented muscle wasting. Paresthesia was noted in 46.2% of PTS individuals and a sensory loss was reported in 34.6% of patients. The present systematic review highlights the necessity of having a high index of suspicion of PTS in patients with previous SARS-CoV-2 infection, as the clinical manifestations can be variable. Also, there is a need for a standardized approach to investigation and reporting on PTS. Future studies should aim for a comprehensive assessment of patients. Factors including the baseline characteristics of the patients, evolution, and treatments should be consistently assessed across studies. In addition, a thorough differential diagnosis should be employed.https://www.mdpi.com/2227-9059/11/3/837Parsonage-Turner syndromeneuralgic amyotrophySARS-CoV-2COVID-19systematic review |
| spellingShingle | Amalia Cornea Irina Lata Mihaela Simu Elena Cecilia Rosca Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic Review Biomedicines Parsonage-Turner syndrome neuralgic amyotrophy SARS-CoV-2 COVID-19 systematic review |
| title | Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic Review |
| title_full | Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic Review |
| title_fullStr | Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic Review |
| title_full_unstemmed | Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic Review |
| title_short | Parsonage-Turner Syndrome Following SARS-CoV-2 Infection: A Systematic Review |
| title_sort | parsonage turner syndrome following sars cov 2 infection a systematic review |
| topic | Parsonage-Turner syndrome neuralgic amyotrophy SARS-CoV-2 COVID-19 systematic review |
| url | https://www.mdpi.com/2227-9059/11/3/837 |
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