Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma
Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clini...
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2002-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2002/0042-84500201029T.pdf |
| _version_ | 1811327221983346688 |
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| author | Topić Brano Stanković Nebojša Savjak Dragutin Grbić Slavko |
| author_facet | Topić Brano Stanković Nebojša Savjak Dragutin Grbić Slavko |
| author_sort | Topić Brano |
| collection | DOAJ |
| description | Correlation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma. |
| first_indexed | 2024-04-13T15:02:55Z |
| format | Article |
| id | doaj.art-061a59330d184fb0ae652ec972e6a763 |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-04-13T15:02:55Z |
| publishDate | 2002-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-061a59330d184fb0ae652ec972e6a7632022-12-22T02:42:14ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502002-01-01591293210.2298/VSP0201029TCorrelation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinomaTopić BranoStanković NebojšaSavjak DragutinGrbić SlavkoCorrelation of standard path morphological prognostic parameters, primary tumor size and axillary nodal status with new prognostic factor in breast carcinoma: tumor suppressor gene p53 was analyzed. The studied sample included 65 women who underwent surgery for breast carcinoma at the Surgical Clinic of Clinical Center Banja Luka, from January 1st 1997 till January 1st 1999. Statistical data analysis was performed and correlation of prognostic factors was determined. The majority of authors in this field agree that the primary tumor size and axillary nodal status are the two most important prognostic factors. These factors are the best predictors of prognosis and survival of women who had the tumor and were operated on. Tumor markers were immunohistochemically determined in the last ten years and, according to the majority of authors, are still considered the additional or relative prognostic factors in breast carcinoma. Their prognostic value and significance increase almost daily. Most frequently determined tumor markers are bcl-2, pS2, Ki-67 and p53. There was a positive, directly proportional relationship between primary tumor size and tumor suppressor gene p53, but there was no positive correlation between the axillary nodal status and tumor suppressor gene p53. Significance of determination of new tumor markers as the prognostic factors was emphasized. These markers represent a powerful tool in the early detection and prevention of breast carcinoma.http://www.doiserbia.nb.rs/img/doi/0042-8450/2002/0042-84500201029T.pdfbreast neoplasmscarcinomaaxillalymph nodeslymph node excisiontumor markersbiologicalprognosis |
| spellingShingle | Topić Brano Stanković Nebojša Savjak Dragutin Grbić Slavko Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma Vojnosanitetski Pregled breast neoplasms carcinoma axilla lymph nodes lymph node excision tumor markers biological prognosis |
| title | Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma |
| title_full | Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma |
| title_fullStr | Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma |
| title_full_unstemmed | Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma |
| title_short | Correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma |
| title_sort | correlation of primary tumor size and axillary nodal status with tumor suppressor gene p53 in breast carcinoma |
| topic | breast neoplasms carcinoma axilla lymph nodes lymph node excision tumor markers biological prognosis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2002/0042-84500201029T.pdf |
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