| Summary: | Yan-Bin Liu,1 Li-Juan Zuo,2 Ya-Chao Liu,1 Yan-Ping Li,1 Yun-Chao Xin,1 Hong-Yan Zhang,3 Li-Yuan Hou4 1Department of ENT & HN Surgery, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei, 075000, People’s Republic of China; 2Department of Endocrine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei, 075000, People’s Republic of China; 3Departmentof Psychiatry, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei, 075000, People’s Republic of China; 4Department of Nuclear Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou City, Hebei, 075000, People’s Republic of ChinaCorrespondence: Yan-Bin Liu, Department of ENT & HN Surgery, The First Affiliated Hospital of Hebei North University, No. 12, Changqing Street, Qiaoxi District, Zhangjiakou, Hebei, 075000, People’s Republic of China, Email liuyanbin19830524@163.comObjective: This study aimed to design a standard method of psychological intervention and evaluate the effect of such psychological intervention against the psychological distress of differentiated thyroid cancer (DTC) patients in the treatment with radioactive iodine.Methods: The enrolled patients were randomly divided into the intervention group and the control group. Both the patients in the 2 groups received the routine nursing care, while the patients in the intervention group also received the additional standard psychological interventions. The questionnaires including patient health questionnaire-9 (PHQ-9), generalized anxiety disorder 7-item (GAD-7), cancer fatigue scale (CFS) and positive and negative affect schedule (PANAS) were used to assess psychological status. These questionnaires were performed at week 0 (T0), week 8 (T1, immediately after the last time of intervention) and week 24 (T2, 16 weeks after the intervention).Results: PHQ-9, GAD-7, CFS and Negative Affect (NA) scores measured at T1 and T2 in the intervention group were significantly lower than those in the control group (P < 0.001). And intervention group also had higher positive affect (PA) scores at T1 and T2 (P < 0.001). Furthermore, the changes of PHQ-9, GAD-7, CFS, PA and NA scores from T0 to T1 and T0 to T2 were more evident in the intervention group than in the control group.Conclusion: Psychological intervention could significantly improve psychological distress of DTC patients in the treatment with radioactive iodine.Keywords: differentiated thyroid cancer, radioactive iodine, psychological intervention, psychological distress, mood
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