Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles
ABSTRACT<br /> In this paper the synthesis of 4-substituted benzoxazole [3,4-b] imidazole (9,10) and 4-aryl hexahydrobenzoxazole [3,4-b] imidazole (13,14) is reported. Glycine was treated with benzoyl chloride or p-nitrobenzoyl chloride to give N-aroyl glycine (1,2), the reaction of N-aroyl gl...
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| Format: | Article |
| Language: | Arabic |
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College of Education for Pure Sciences
1970-01-01
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| Series: | مجلة التربية والعلم |
| Subjects: | |
| Online Access: | https://edusj.mosuljournals.com/article_57443_1d7582214c1cb0fdaa9a94c0a73a63fd.pdf |
| _version_ | 1819115546700939264 |
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| author | Yaser Al-Jawharji |
| author_facet | Yaser Al-Jawharji |
| author_sort | Yaser Al-Jawharji |
| collection | DOAJ |
| description | ABSTRACT<br /> In this paper the synthesis of 4-substituted benzoxazole [3,4-b] imidazole (9,10) and 4-aryl hexahydrobenzoxazole [3,4-b] imidazole (13,14) is reported. Glycine was treated with benzoyl chloride or p-nitrobenzoyl chloride to give N-aroyl glycine (1,2), the reaction of N-aroyl glycine with thionyl chloride followed by treatment the product (3,4) with ammonium hydroxide to give N-aroyl glycine amide (5,6). Treatment of the amide with 1-bromocyclohexanone gave N-methylene-2-hexahydrobenzoxazole) aryl amide (7,8), cyclization of this gave product (9,10), whereas the compounds (13,14) was synthesized from o-aminophenol and the acid chlorides to give N-methylene (2-benzoxazole) aryl amide (11,12) which cyclized with phosphorous oxychloride to give the products (13,14).<br /> The structure of all synthesized compounds were confirmed by physical and spectral data. |
| first_indexed | 2024-12-22T05:02:55Z |
| format | Article |
| id | doaj.art-061bdf8b3cfd4052b538736dea220026 |
| institution | Directory Open Access Journal |
| issn | 1812-125X 2664-2530 |
| language | Arabic |
| last_indexed | 2024-12-22T05:02:55Z |
| publishDate | 1970-01-01 |
| publisher | College of Education for Pure Sciences |
| record_format | Article |
| series | مجلة التربية والعلم |
| spelling | doaj.art-061bdf8b3cfd4052b538736dea2200262022-12-21T18:38:11ZaraCollege of Education for Pure Sciencesمجلة التربية والعلم1812-125X2664-25301970-01-01221111810.33899/edusj.1970.5744357443Synthesis of Some Substituted Benzoxazole [3,4-b] imidazolesYaser Al-Jawharji0Department of Chemistry, College of Education, University of Mosul, Mosul, IraqABSTRACT<br /> In this paper the synthesis of 4-substituted benzoxazole [3,4-b] imidazole (9,10) and 4-aryl hexahydrobenzoxazole [3,4-b] imidazole (13,14) is reported. Glycine was treated with benzoyl chloride or p-nitrobenzoyl chloride to give N-aroyl glycine (1,2), the reaction of N-aroyl glycine with thionyl chloride followed by treatment the product (3,4) with ammonium hydroxide to give N-aroyl glycine amide (5,6). Treatment of the amide with 1-bromocyclohexanone gave N-methylene-2-hexahydrobenzoxazole) aryl amide (7,8), cyclization of this gave product (9,10), whereas the compounds (13,14) was synthesized from o-aminophenol and the acid chlorides to give N-methylene (2-benzoxazole) aryl amide (11,12) which cyclized with phosphorous oxychloride to give the products (13,14).<br /> The structure of all synthesized compounds were confirmed by physical and spectral data.https://edusj.mosuljournals.com/article_57443_1d7582214c1cb0fdaa9a94c0a73a63fd.pdfsubstituted benzoxazole[34-b] imidazolesaryl hexahydrobenzoxazole [34-b] imidazole |
| spellingShingle | Yaser Al-Jawharji Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles مجلة التربية والعلم substituted benzoxazole [3 4-b] imidazoles aryl hexahydrobenzoxazole [3 4-b] imidazole |
| title | Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles |
| title_full | Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles |
| title_fullStr | Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles |
| title_full_unstemmed | Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles |
| title_short | Synthesis of Some Substituted Benzoxazole [3,4-b] imidazoles |
| title_sort | synthesis of some substituted benzoxazole 3 4 b imidazoles |
| topic | substituted benzoxazole [3 4-b] imidazoles aryl hexahydrobenzoxazole [3 4-b] imidazole |
| url | https://edusj.mosuljournals.com/article_57443_1d7582214c1cb0fdaa9a94c0a73a63fd.pdf |
| work_keys_str_mv | AT yaseraljawharji synthesisofsomesubstitutedbenzoxazole34bimidazoles |