The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer
As an important complementary imaging agent for 18F-FDG, 18F-fluoroethyl-choline (18F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer, 18F-FECH was synthesized by different reagents and consumable supplies. The C18 c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Board of Journal of Isotopes
2016-02-01
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| Series: | Journal of Isotopes |
| Subjects: | |
| Online Access: | http://www.tws.org.cn/CN/10.7538/tws.2016.29.01.0019 |
| Summary: | As an important complementary imaging agent for 18F-FDG, 18F-fluoroethyl-choline (18F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer, 18F-FECH was synthesized by different reagents and consumable supplies. The C18 column was added before the product collection bottle to remove K2.2.2. The 18F-FECH was synthesized by PET-FDG-IT-I synthesizer efficiently about 30 minutes by radiochemical yield of 42.0% (no decay corrected, n=5), and the radiochemical purity was still more than 99.0% after 6 hours. The results showed the domestic PET-FDG-IT-I synthesizer could semi-automatically synthesize injectable 18F-FECH in high efficiency and radiochemical purity |
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| ISSN: | 1000-7512 1000-7512 |