The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer
As an important complementary imaging agent for 18F-FDG, 18F-fluoroethyl-choline (18F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer, 18F-FECH was synthesized by different reagents and consumable supplies. The C18 c...
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| Format: | Article |
| Language: | zho |
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Editorial Board of Journal of Isotopes
2016-02-01
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| Series: | Journal of Isotopes |
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| Online Access: | http://www.tws.org.cn/CN/10.7538/tws.2016.29.01.0019 |
| _version_ | 1818849587911196672 |
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| author | ZHOU Ming ZHANG Xiao-jun LIU Jian LI Yun-gang |
| author_facet | ZHOU Ming ZHANG Xiao-jun LIU Jian LI Yun-gang |
| author_sort | ZHOU Ming |
| collection | DOAJ |
| description | As an important complementary imaging agent for 18F-FDG, 18F-fluoroethyl-choline (18F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer, 18F-FECH was synthesized by different reagents and consumable supplies. The C18 column was added before the product collection bottle to remove K2.2.2. The 18F-FECH was synthesized by PET-FDG-IT-I synthesizer efficiently about 30 minutes by radiochemical yield of 42.0% (no decay corrected, n=5), and the radiochemical purity was still more than 99.0% after 6 hours. The results showed the domestic PET-FDG-IT-I synthesizer could semi-automatically synthesize injectable 18F-FECH in high efficiency and radiochemical purity |
| first_indexed | 2024-12-19T06:35:37Z |
| format | Article |
| id | doaj.art-061e57767d2347d28b9550c9786472e1 |
| institution | Directory Open Access Journal |
| issn | 1000-7512 1000-7512 |
| language | zho |
| last_indexed | 2024-12-19T06:35:37Z |
| publishDate | 2016-02-01 |
| publisher | Editorial Board of Journal of Isotopes |
| record_format | Article |
| series | Journal of Isotopes |
| spelling | doaj.art-061e57767d2347d28b9550c9786472e12022-12-21T20:32:14ZzhoEditorial Board of Journal of IsotopesJournal of Isotopes1000-75121000-75122016-02-01291192410.7538/tws.2016.29.01.0019 The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG SynthesizerZHOU Ming0ZHANG Xiao-jun1LIU Jian2LI Yun-gang3PET Center, Department of Nuclear Medicine, XiangYa HospitalDepartment of Nuclear Medicine, the PLA General HospitalDepartment of Nuclear Medicine, the PLA General HospitalDepartment of Nuclear Medicine, the PLA General HospitalAs an important complementary imaging agent for 18F-FDG, 18F-fluoroethyl-choline (18F-FECH) has been demonstrated to be promising in brain and prostate cancer imaging. By using domestic PET-FDG-TI-I CPCU synthesizer, 18F-FECH was synthesized by different reagents and consumable supplies. The C18 column was added before the product collection bottle to remove K2.2.2. The 18F-FECH was synthesized by PET-FDG-IT-I synthesizer efficiently about 30 minutes by radiochemical yield of 42.0% (no decay corrected, n=5), and the radiochemical purity was still more than 99.0% after 6 hours. The results showed the domestic PET-FDG-IT-I synthesizer could semi-automatically synthesize injectable 18F-FECH in high efficiency and radiochemical purityhttp://www.tws.org.cn/CN/10.7538/tws.2016.29.01.0019 18F-fluoroethyl-choline (18F-FECH)PETimaging agent |
| spellingShingle | ZHOU Ming ZHANG Xiao-jun LIU Jian LI Yun-gang The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer Journal of Isotopes 18F-fluoroethyl-choline (18F-FECH) PET imaging agent |
| title | The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer |
| title_full | The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer |
| title_fullStr | The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer |
| title_full_unstemmed | The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer |
| title_short | The Semi-automatic Synthesis of 18F-fluoroethyl-choline by Domestic FDG Synthesizer |
| title_sort | semi automatic synthesis of 18f fluoroethyl choline by domestic fdg synthesizer |
| topic | 18F-fluoroethyl-choline (18F-FECH) PET imaging agent |
| url | http://www.tws.org.cn/CN/10.7538/tws.2016.29.01.0019 |
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