Activity of omadacycline in vitro against Clostridioides difficile and preliminary efficacy assessment in a hamster model of C. difficile-associated diarrhoea

Activity of omadacycline in vitro against Clostridioides difficile and preliminary efficacy assessment in a hamster model of C. difficile-associated diarrhoea

ABSTRACT: Objectives: Antibiotics are associated with increased risk of Clostridioides difficile infection, which has limited treatment options. We assessed in vitro activity of omadacycline (an aminomethylcycline antibiotic) against the C. difficile infection strain and efficacy in a hamster model...

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Bibliographic Details
Main Authors: Raina Gay Leahy, Alisa W. Serio, Kelly Wright, Maria M. Traczewski, S. Ken Tanaka
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Journal of Global Antimicrobial Resistance
Subjects:
Clostridioides difficile
Clostridium difficile
Omadacycline
Hamster model
Survival
Minimum inhibitory concentration
Online Access:http://www.sciencedirect.com/science/article/pii/S2213716522000960

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