Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions
Drug-polymer miscibility is a critical requirement for the efficient design and development of amorphous solid dispersions. The objective of the current study was to determine the miscibility between dapsone (DAP) and poly(1-vinylpyrrolidone-co-vinyl acetate) (PVP-VA) through theoretical and experim...
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023013749 |
| _version_ | 1797851822729199616 |
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| author | Dinesh Choudhury Upadhyayula Suryanarayana Murty Subham Banerjee |
| author_facet | Dinesh Choudhury Upadhyayula Suryanarayana Murty Subham Banerjee |
| author_sort | Dinesh Choudhury |
| collection | DOAJ |
| description | Drug-polymer miscibility is a critical requirement for the efficient design and development of amorphous solid dispersions. The objective of the current study was to determine the miscibility between dapsone (DAP) and poly(1-vinylpyrrolidone-co-vinyl acetate) (PVP-VA) through theoretical and experimental approaches, including the use of a thermodynamic phase diagram and Gibbs free energy of mixing. In the theoretical study, the difference in the solubility parameter between the DAP and PVP-VA was 2.74, the interaction parameter was 0.50, and the distance between the drug and polymer in the Bagley plot was 2.60. Hence, all these theoretical parameters favour the miscibility between DAP and PVP-VA. Melting point depression study (through thermal analysis) and Flory-Huggins theory were utilized for the practical determination of drug-polymer miscibility, where the interaction parameter was positive, suggesting limited miscibility. The obtained thermodynamic phase diagram and Gibbs free energy of mixing plot can provide an indication for the selection of appropriate drug-polymer ratios in stable and metastable zones and the optimum processing temperature required for the preparation of amorphous solid dispersions. |
| first_indexed | 2024-04-09T19:24:04Z |
| format | Article |
| id | doaj.art-061ffb5759624de1b80275e9c9024541 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:24:04Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-061ffb5759624de1b80275e9c90245412023-04-05T08:21:06ZengElsevierHeliyon2405-84402023-03-0193e14167Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersionsDinesh Choudhury0Upadhyayula Suryanarayana Murty1Subham Banerjee2Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER)-Guwahati, Changsari-781101, Kamrup (Rural), Assam, India; National Centre for Pharmacoengineering, Changsari-781101, Kamrup (Rural), Assam, IndiaNational Centre for Pharmacoengineering, Changsari-781101, Kamrup (Rural), Assam, India; NIPER-Guwahati, Changsari-781101 Kamrup (Rural), Assam, IndiaDepartment of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER)-Guwahati, Changsari-781101, Kamrup (Rural), Assam, India; National Centre for Pharmacoengineering, Changsari-781101, Kamrup (Rural), Assam, India; Corresponding author. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER)-Guwahati, Changsari-781101, Kamrup (Rural), Assam, India.Drug-polymer miscibility is a critical requirement for the efficient design and development of amorphous solid dispersions. The objective of the current study was to determine the miscibility between dapsone (DAP) and poly(1-vinylpyrrolidone-co-vinyl acetate) (PVP-VA) through theoretical and experimental approaches, including the use of a thermodynamic phase diagram and Gibbs free energy of mixing. In the theoretical study, the difference in the solubility parameter between the DAP and PVP-VA was 2.74, the interaction parameter was 0.50, and the distance between the drug and polymer in the Bagley plot was 2.60. Hence, all these theoretical parameters favour the miscibility between DAP and PVP-VA. Melting point depression study (through thermal analysis) and Flory-Huggins theory were utilized for the practical determination of drug-polymer miscibility, where the interaction parameter was positive, suggesting limited miscibility. The obtained thermodynamic phase diagram and Gibbs free energy of mixing plot can provide an indication for the selection of appropriate drug-polymer ratios in stable and metastable zones and the optimum processing temperature required for the preparation of amorphous solid dispersions.http://www.sciencedirect.com/science/article/pii/S2405844023013749MiscibilitySolubility parameterInteraction parameterGibbs free energyThermodynamic phase diagram |
| spellingShingle | Dinesh Choudhury Upadhyayula Suryanarayana Murty Subham Banerjee Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions Heliyon Miscibility Solubility parameter Interaction parameter Gibbs free energy Thermodynamic phase diagram |
| title | Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions |
| title_full | Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions |
| title_fullStr | Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions |
| title_full_unstemmed | Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions |
| title_short | Selection of appropriate dapsone and poly(1-vinylpyrrolidone-co-vinyl acetate) ratios for the preparation of amorphous solid dispersions |
| title_sort | selection of appropriate dapsone and poly 1 vinylpyrrolidone co vinyl acetate ratios for the preparation of amorphous solid dispersions |
| topic | Miscibility Solubility parameter Interaction parameter Gibbs free energy Thermodynamic phase diagram |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023013749 |
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