DDX5 Functions as a Tumor Suppressor in Tongue Cancer
DEAD-box polypeptide 5 (DDX5), a DEAD-box RNA helicase, is a multifunctional protein that plays important roles in many physiological and pathological processes. Contrary to its documented oncogenic role in a wide array of cancers, we herein demonstrate that DDX5 serves as a tumor suppressor in tong...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/24/5882 |
| _version_ | 1797381636171497472 |
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| author | Qingqing Liu Yangqing Sun Min Long Xueyan Chen Shangwei Zhong Changhao Huang Rui Wei Jun-Li Luo |
| author_facet | Qingqing Liu Yangqing Sun Min Long Xueyan Chen Shangwei Zhong Changhao Huang Rui Wei Jun-Li Luo |
| author_sort | Qingqing Liu |
| collection | DOAJ |
| description | DEAD-box polypeptide 5 (DDX5), a DEAD-box RNA helicase, is a multifunctional protein that plays important roles in many physiological and pathological processes. Contrary to its documented oncogenic role in a wide array of cancers, we herein demonstrate that DDX5 serves as a tumor suppressor in tongue cancer. The high expression of DDX5 is correlated with better prognosis for clinical tongue cancer patients. DDX5 downregulates the genes associated with tongue cancer progression. The knockdown of DDX5 promotes, while the overexpression of DDX5 inhibits, tongue cancer proliferation, development, and cisplatin resistance. Furthermore, the expression of DDX5 in tongue cancer is associated with immune cell infiltration in the tumor microenvironment. Specifically, the expression of DDX5 is associated with the reduced infiltration of M2 macrophages and increased infiltration of T cell clusters, which may contribute to anticancer effects in the tumor microenvironment. In this study, we establish DDX5 as a valuable prognostic biomarker and an important tumor suppressor in tongue cancer. |
| first_indexed | 2024-03-08T20:54:19Z |
| format | Article |
| id | doaj.art-0623285da79e48209b18ffeca2b16a16 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-08T20:54:19Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-0623285da79e48209b18ffeca2b16a162023-12-22T13:59:09ZengMDPI AGCancers2072-66942023-12-011524588210.3390/cancers15245882DDX5 Functions as a Tumor Suppressor in Tongue CancerQingqing Liu0Yangqing Sun1Min Long2Xueyan Chen3Shangwei Zhong4Changhao Huang5Rui Wei6Jun-Li Luo7Department of Oncology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, Changsha 410008, ChinaThe Cancer Research Institute and the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, Changsha 410008, ChinaThe Cancer Research Institute and the Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, ChinaThe Organ Transplant Center, Xiangya Hospital Central South University, Changsha 410000, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDepartment of Oncology, Xiangya Hospital, Central South University, Changsha 410008, ChinaDEAD-box polypeptide 5 (DDX5), a DEAD-box RNA helicase, is a multifunctional protein that plays important roles in many physiological and pathological processes. Contrary to its documented oncogenic role in a wide array of cancers, we herein demonstrate that DDX5 serves as a tumor suppressor in tongue cancer. The high expression of DDX5 is correlated with better prognosis for clinical tongue cancer patients. DDX5 downregulates the genes associated with tongue cancer progression. The knockdown of DDX5 promotes, while the overexpression of DDX5 inhibits, tongue cancer proliferation, development, and cisplatin resistance. Furthermore, the expression of DDX5 in tongue cancer is associated with immune cell infiltration in the tumor microenvironment. Specifically, the expression of DDX5 is associated with the reduced infiltration of M2 macrophages and increased infiltration of T cell clusters, which may contribute to anticancer effects in the tumor microenvironment. In this study, we establish DDX5 as a valuable prognostic biomarker and an important tumor suppressor in tongue cancer.https://www.mdpi.com/2072-6694/15/24/5882DDX5tumor suppressortongue cancerCD8+ T cellmacrophageimmune cell infiltration |
| spellingShingle | Qingqing Liu Yangqing Sun Min Long Xueyan Chen Shangwei Zhong Changhao Huang Rui Wei Jun-Li Luo DDX5 Functions as a Tumor Suppressor in Tongue Cancer Cancers DDX5 tumor suppressor tongue cancer CD8+ T cell macrophage immune cell infiltration |
| title | DDX5 Functions as a Tumor Suppressor in Tongue Cancer |
| title_full | DDX5 Functions as a Tumor Suppressor in Tongue Cancer |
| title_fullStr | DDX5 Functions as a Tumor Suppressor in Tongue Cancer |
| title_full_unstemmed | DDX5 Functions as a Tumor Suppressor in Tongue Cancer |
| title_short | DDX5 Functions as a Tumor Suppressor in Tongue Cancer |
| title_sort | ddx5 functions as a tumor suppressor in tongue cancer |
| topic | DDX5 tumor suppressor tongue cancer CD8+ T cell macrophage immune cell infiltration |
| url | https://www.mdpi.com/2072-6694/15/24/5882 |
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