New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells
Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F5a monoester (1), 23-valine demalonylazalomycin F5a ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F3a ester (3), F4a est...
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| Format: | Article |
| Language: | English |
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MDPI AG
2013-03-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/3/817 |
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| author | Haipeng Lin Zhigang She Jia Li Kui Hong Ganjun Yuan |
| author_facet | Haipeng Lin Zhigang She Jia Li Kui Hong Ganjun Yuan |
| author_sort | Haipeng Lin |
| collection | DOAJ |
| description | Seven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F5a monoester (1), 23-valine demalonylazalomycin F5a ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F3a ester (3), F4a ester (4) and F5a ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F4a ester (6) and 23-(10-methyl)undecanoic acid demalony lazalomycin F4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F3a, F4a and F5a. Biological assays exhibited that 1–7 showed broad-spectrum antimicrobial and anti HCT-116 activities. |
| first_indexed | 2024-04-11T11:12:29Z |
| format | Article |
| id | doaj.art-06239499a0db4461b98553f1eaa717d4 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T11:12:29Z |
| publishDate | 2013-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-06239499a0db4461b98553f1eaa717d42022-12-22T04:27:26ZengMDPI AGMarine Drugs1660-33972013-03-0111381782910.3390/md11030817New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer CellsHaipeng LinZhigang SheJia LiKui HongGanjun YuanSeven new azalomycin F analogs (1–7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F5a monoester (1), 23-valine demalonylazalomycin F5a ester (2), 23-(6-methyl)heptanoic acid demalonylazalomycins F3a ester (3), F4a ester (4) and F5a ester (5), 23-(9-methyl)decanoic acid demalonylazalomycin F4a ester (6) and 23-(10-methyl)undecanoic acid demalony lazalomycin F4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F3a, F4a and F5a. Biological assays exhibited that 1–7 showed broad-spectrum antimicrobial and anti HCT-116 activities.http://www.mdpi.com/1660-3397/11/3/817azalomycin FStreptomyces sp. 211726cytotoxicityantimicrobial activity |
| spellingShingle | Haipeng Lin Zhigang She Jia Li Kui Hong Ganjun Yuan New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells Marine Drugs azalomycin F Streptomyces sp. 211726 cytotoxicity antimicrobial activity |
| title | New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells |
| title_full | New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells |
| title_fullStr | New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells |
| title_full_unstemmed | New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells |
| title_short | New Azalomycin F Analogs from Mangrove Streptomyces sp. 211726 with Activity against Microbes and Cancer Cells |
| title_sort | new azalomycin f analogs from mangrove streptomyces sp 211726 with activity against microbes and cancer cells |
| topic | azalomycin F Streptomyces sp. 211726 cytotoxicity antimicrobial activity |
| url | http://www.mdpi.com/1660-3397/11/3/817 |
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