The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid Arthritis
To evaluate the changes in anti cyclic citrullinated peptide (Anti-CCP) antibodies, rheumatoid factor (RF), interleukins 17 and 10 (IL-17 and IL-10), high sensitivity C- reactive protein (hs CRP) and T regulatory cells (Treg) count following an anti TNF-α biological agent (etanercept) therapy in pa...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacy / Mustansiriyah University
2014-06-01
|
| Series: | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/121 |
| _version_ | 1797223900146302976 |
|---|---|
| author | Madha Mohammed Sheet Laith Abdul-Elah Kamel Jamal Nasser Farhood |
| author_facet | Madha Mohammed Sheet Laith Abdul-Elah Kamel Jamal Nasser Farhood |
| author_sort | Madha Mohammed Sheet |
| collection | DOAJ |
| description |
To evaluate the changes in anti cyclic citrullinated peptide (Anti-CCP) antibodies,
rheumatoid factor (RF), interleukins 17 and 10 (IL-17 and IL-10), high sensitivity C- reactive
protein (hs CRP) and T regulatory cells (Treg) count following an anti TNF-α biological agent
(etanercept) therapy in patients with rheumatoid arthritis.
Refractory rheumatoid arthritis patients who failed treatment with DMARDs (disease
modifying anti rheumatic drugs) were treated with etanercept for three months. Serum and blood
samples were tested before and after therapy for six markers including ACCP, RF, IL- 10, IL 17,
hs CRP, and Treg cell. A significant dropping down in the serum level of ACCP, RF and hs CRP
was documented 3 months after etanercept therapy. On the other hand a non- significant elevation
in IL-10 serum level and peripheral blood Treg cell count, as well as a non significant dropping
down in the serum level of IL-17 were also reported. Etanercept is a successful anti-TNF-α
therapy in refractory RA patients for the first three months of the course therapy as indicated by
clinical improvement and amelioration in 6 disease activity markers.
|
| first_indexed | 2024-04-24T13:44:34Z |
| format | Article |
| id | doaj.art-062433fee1594188b65f112d1e034623 |
| institution | Directory Open Access Journal |
| issn | 1815-0993 2959-183X |
| language | English |
| last_indexed | 2024-04-24T13:44:34Z |
| publishDate | 2014-06-01 |
| publisher | College of Pharmacy / Mustansiriyah University |
| record_format | Article |
| series | Al-Mustansiriyah Journal of Pharmaceutical Sciences |
| spelling | doaj.art-062433fee1594188b65f112d1e0346232024-04-04T06:58:30ZengCollege of Pharmacy / Mustansiriyah UniversityAl-Mustansiriyah Journal of Pharmaceutical Sciences1815-09932959-183X2014-06-0114110.32947/ajps.v14i1.121The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid ArthritisMadha Mohammed Sheet0Laith Abdul-Elah Kamel1Jamal Nasser Farhood2Dept. Medical Labs., College of Health andMedical Technology, BaghdadAl-Karama Hospital, BaghdadDept. Medical Labs, College of Health andMedical Technology, Baghdad To evaluate the changes in anti cyclic citrullinated peptide (Anti-CCP) antibodies, rheumatoid factor (RF), interleukins 17 and 10 (IL-17 and IL-10), high sensitivity C- reactive protein (hs CRP) and T regulatory cells (Treg) count following an anti TNF-α biological agent (etanercept) therapy in patients with rheumatoid arthritis. Refractory rheumatoid arthritis patients who failed treatment with DMARDs (disease modifying anti rheumatic drugs) were treated with etanercept for three months. Serum and blood samples were tested before and after therapy for six markers including ACCP, RF, IL- 10, IL 17, hs CRP, and Treg cell. A significant dropping down in the serum level of ACCP, RF and hs CRP was documented 3 months after etanercept therapy. On the other hand a non- significant elevation in IL-10 serum level and peripheral blood Treg cell count, as well as a non significant dropping down in the serum level of IL-17 were also reported. Etanercept is a successful anti-TNF-α therapy in refractory RA patients for the first three months of the course therapy as indicated by clinical improvement and amelioration in 6 disease activity markers. https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/121rheumatoid arthritis, IL-17, etanercept, Treg, TNF-α |
| spellingShingle | Madha Mohammed Sheet Laith Abdul-Elah Kamel Jamal Nasser Farhood The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid Arthritis Al-Mustansiriyah Journal of Pharmaceutical Sciences rheumatoid arthritis, IL-17, etanercept, Treg, TNF-α |
| title | The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid Arthritis |
| title_full | The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid Arthritis |
| title_fullStr | The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid Arthritis |
| title_full_unstemmed | The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid Arthritis |
| title_short | The Role of Anti-TNFα Therapy in the Amelioration of Disease Burden in Patients with Refractory Rheumatoid Arthritis |
| title_sort | role of anti tnfα therapy in the amelioration of disease burden in patients with refractory rheumatoid arthritis |
| topic | rheumatoid arthritis, IL-17, etanercept, Treg, TNF-α |
| url | https://ajps.uomustansiriyah.edu.iq/index.php/AJPS/article/view/121 |
| work_keys_str_mv | AT madhamohammedsheet theroleofantitnfatherapyintheameliorationofdiseaseburdeninpatientswithrefractoryrheumatoidarthritis AT laithabdulelahkamel theroleofantitnfatherapyintheameliorationofdiseaseburdeninpatientswithrefractoryrheumatoidarthritis AT jamalnasserfarhood theroleofantitnfatherapyintheameliorationofdiseaseburdeninpatientswithrefractoryrheumatoidarthritis AT madhamohammedsheet roleofantitnfatherapyintheameliorationofdiseaseburdeninpatientswithrefractoryrheumatoidarthritis AT laithabdulelahkamel roleofantitnfatherapyintheameliorationofdiseaseburdeninpatientswithrefractoryrheumatoidarthritis AT jamalnasserfarhood roleofantitnfatherapyintheameliorationofdiseaseburdeninpatientswithrefractoryrheumatoidarthritis |