Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey
ObjectivesThis study aimed to investigate the relationship between frailty and all-cause mortality in hypertensive population.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANES) 1999–2002 and mortality data from the National Death Index. Frailty was assessed using...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.945468/full |
| _version_ | 1797839984586129408 |
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| author | Li Li Yuge Wang Chunlei Yang Chenhui Huang Lanzhi Duan Jianghua Zhou Yanyu Lu Guojun Zhao |
| author_facet | Li Li Yuge Wang Chunlei Yang Chenhui Huang Lanzhi Duan Jianghua Zhou Yanyu Lu Guojun Zhao |
| author_sort | Li Li |
| collection | DOAJ |
| description | ObjectivesThis study aimed to investigate the relationship between frailty and all-cause mortality in hypertensive population.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANES) 1999–2002 and mortality data from the National Death Index. Frailty was assessed using the revised version of the Fried frailty criteria (weakness, exhaustion, low physical activity, shrinking, and slowness). This study aimed to evaluate the association between frailty and all-cause mortality. Cox proportional hazard models were used to evaluate the association between frailty category and all-cause mortality, adjusted for age, sex, race, education, poverty–income ratio, smoking, alcohol, diabetes, arthritis, congestive heart failure, coronary heart disease, stroke, overweight, cancer or malignancy, chronic obstructive pulmonary disease, chronic kidney disease, and taking medicine for hypertension.ResultsWe gathered data of 2,117 participants with hypertension; 17.81%, 28.77%, and 53.42% were classified as frail, pre-frail, and robust, respectively. We found that frail [hazard ratio (HR) = 2.76, 95% confidence interval (CI) = 2.33–3.27] and pre-frail (HR = 1.38, 95% CI = 1.19–1.59] were significantly associated with all-cause mortality after controlling for variables. We found that frail (HR = 3.02, 95% CI = 2.50–3.65) and pre-frail (HR = 1.35, 95% CI = 1.15–1.58) were associated with all-cause mortality in the age group ≥65 years. For the frailty components, weakness (HR = 1.77, 95% CI = 1.55–2.03), exhaustion (HR = 2.25, 95% CI = 1.92–2.65), low physical activity (HR = 2.25, 95% CI = 1.95–2.61), shrinking (HR = 1.48, 95% CI = 1.13–1.92), and slowness (HR = 1.44, 95% CI = 1.22–1.69) were associated with all-cause mortality.ConclusionThis study demonstrated that frailty and pre-frailty were associated with an increased risk of all-cause mortality in patients with hypertension. More attention should be paid to frailty in hypertensive patients, and interventions to reduce the burden of frailty may improve outcomes in these patients. |
| first_indexed | 2024-04-09T16:05:54Z |
| format | Article |
| id | doaj.art-0624f2c9d4ff4983b4bdf12f4ac10e9f |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-09T16:05:54Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-0624f2c9d4ff4983b4bdf12f4ac10e9f2023-04-25T05:15:12ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-04-011010.3389/fcvm.2023.945468945468Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination SurveyLi Li0Yuge Wang1Chunlei Yang2Chenhui Huang3Lanzhi Duan4Jianghua Zhou5Yanyu Lu6Guojun Zhao7Department of Cardiovascular Surgery, The First Affliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Medicine, Jinggangshan University, Ji'an, ChinaDepartment of Cardiology, The First Affliated Hospital of Zhengzhou University, Zhengzhou, ChinaCollege of Nursing, Wenzhou Medical University, Wenzhou, ChinaDepartment of Medicine, Jinggangshan University, Ji'an, ChinaDepartment of Cardiology, The First Affliated Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Cardiology, The First Affliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cardiology, The First Affliated Hospital of Zhengzhou University, Zhengzhou, ChinaObjectivesThis study aimed to investigate the relationship between frailty and all-cause mortality in hypertensive population.MethodsWe used data from the National Health and Nutrition Examination Survey (NHANES) 1999–2002 and mortality data from the National Death Index. Frailty was assessed using the revised version of the Fried frailty criteria (weakness, exhaustion, low physical activity, shrinking, and slowness). This study aimed to evaluate the association between frailty and all-cause mortality. Cox proportional hazard models were used to evaluate the association between frailty category and all-cause mortality, adjusted for age, sex, race, education, poverty–income ratio, smoking, alcohol, diabetes, arthritis, congestive heart failure, coronary heart disease, stroke, overweight, cancer or malignancy, chronic obstructive pulmonary disease, chronic kidney disease, and taking medicine for hypertension.ResultsWe gathered data of 2,117 participants with hypertension; 17.81%, 28.77%, and 53.42% were classified as frail, pre-frail, and robust, respectively. We found that frail [hazard ratio (HR) = 2.76, 95% confidence interval (CI) = 2.33–3.27] and pre-frail (HR = 1.38, 95% CI = 1.19–1.59] were significantly associated with all-cause mortality after controlling for variables. We found that frail (HR = 3.02, 95% CI = 2.50–3.65) and pre-frail (HR = 1.35, 95% CI = 1.15–1.58) were associated with all-cause mortality in the age group ≥65 years. For the frailty components, weakness (HR = 1.77, 95% CI = 1.55–2.03), exhaustion (HR = 2.25, 95% CI = 1.92–2.65), low physical activity (HR = 2.25, 95% CI = 1.95–2.61), shrinking (HR = 1.48, 95% CI = 1.13–1.92), and slowness (HR = 1.44, 95% CI = 1.22–1.69) were associated with all-cause mortality.ConclusionThis study demonstrated that frailty and pre-frailty were associated with an increased risk of all-cause mortality in patients with hypertension. More attention should be paid to frailty in hypertensive patients, and interventions to reduce the burden of frailty may improve outcomes in these patients.https://www.frontiersin.org/articles/10.3389/fcvm.2023.945468/fullfrailtypre-frailtymortalityhypertensionNHANES |
| spellingShingle | Li Li Yuge Wang Chunlei Yang Chenhui Huang Lanzhi Duan Jianghua Zhou Yanyu Lu Guojun Zhao Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey Frontiers in Cardiovascular Medicine frailty pre-frailty mortality hypertension NHANES |
| title | Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey |
| title_full | Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey |
| title_fullStr | Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey |
| title_full_unstemmed | Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey |
| title_short | Frailty in hypertensive population and its association with all-cause mortality: data from the National Health and Nutrition Examination Survey |
| title_sort | frailty in hypertensive population and its association with all cause mortality data from the national health and nutrition examination survey |
| topic | frailty pre-frailty mortality hypertension NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.945468/full |
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