Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns
Preeclampsia is a condition that might severely impact the health of mothers and their newborns. The aim of this investigation is to examine hematological parameters in mothers with preeclampsia and umbilical cord blood. Eighty preecalmptic mothers were recruited in the study. In addition, eighty no...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2018.1441861 |
| _version_ | 1797681349100830720 |
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| author | Mahmoud M. Elgari Omar F. Khabour Samaher M. Alhag |
| author_facet | Mahmoud M. Elgari Omar F. Khabour Samaher M. Alhag |
| author_sort | Mahmoud M. Elgari |
| collection | DOAJ |
| description | Preeclampsia is a condition that might severely impact the health of mothers and their newborns. The aim of this investigation is to examine hematological parameters in mothers with preeclampsia and umbilical cord blood. Eighty preecalmptic mothers were recruited in the study. In addition, eighty normal pregnant mothers served as controls. Hematological parameters that include hemoglobin (Hb), red blood cell count (RBC), red cell distribution width (RDW), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell counts (WBC), platelet counts, mean platelet volume (MPV) and Platelet large cell ratio (PLCR) were examined. Results showed a strong association between preeclampsia and low birth weight, premature/cesarean delivery and proteinuria (P < 0.001). Hb and neutrophils were significantly lower (P < 0.01), whereas RDW, PCV, MCV, MCH, MCHC and lymphocytes were significantly higher than normal ones (P < 0.01). When cord blood of preeclamptic mothers were compared with that of normal ones, similar findings were observed. In addition, results showed significant and positive correlations between preeclamptic mothers and their newborn in Hb (r2 = 0.075, P < 0.05), PCV (r2 = 0.084, P < 0.01), MCV (r2 = 0.077, P < 0.05), MCHC (r2 = 0.115, P < 0.01), RBC (r2 = 0.086, P < 0.01) and retics (r2 = 0.306, P < 0.01). In conclusion, changes in several hematological parameters associated with preeclampsia were correlated in affected mothers and their newborns. Such biomarkers can be used to predict pregnancy outcomes in women with preeclampsia. |
| first_indexed | 2024-03-11T23:43:35Z |
| format | Article |
| id | doaj.art-0625238e48c042ffa2f48ce6808b27b6 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:43:35Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-0625238e48c042ffa2f48ce6808b27b62023-09-19T15:19:26ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062019-01-01411586110.1080/10641963.2018.14418611441861Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newbornsMahmoud M. Elgari0Omar F. Khabour1Samaher M. Alhag2Taibah UniversityTaibah UniversitySudan University for Sciences and TechnologyPreeclampsia is a condition that might severely impact the health of mothers and their newborns. The aim of this investigation is to examine hematological parameters in mothers with preeclampsia and umbilical cord blood. Eighty preecalmptic mothers were recruited in the study. In addition, eighty normal pregnant mothers served as controls. Hematological parameters that include hemoglobin (Hb), red blood cell count (RBC), red cell distribution width (RDW), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), white blood cell counts (WBC), platelet counts, mean platelet volume (MPV) and Platelet large cell ratio (PLCR) were examined. Results showed a strong association between preeclampsia and low birth weight, premature/cesarean delivery and proteinuria (P < 0.001). Hb and neutrophils were significantly lower (P < 0.01), whereas RDW, PCV, MCV, MCH, MCHC and lymphocytes were significantly higher than normal ones (P < 0.01). When cord blood of preeclamptic mothers were compared with that of normal ones, similar findings were observed. In addition, results showed significant and positive correlations between preeclamptic mothers and their newborn in Hb (r2 = 0.075, P < 0.05), PCV (r2 = 0.084, P < 0.01), MCV (r2 = 0.077, P < 0.05), MCHC (r2 = 0.115, P < 0.01), RBC (r2 = 0.086, P < 0.01) and retics (r2 = 0.306, P < 0.01). In conclusion, changes in several hematological parameters associated with preeclampsia were correlated in affected mothers and their newborns. Such biomarkers can be used to predict pregnancy outcomes in women with preeclampsia.http://dx.doi.org/10.1080/10641963.2018.1441861hypertensionpreeclampsiacord bloodpregnancybiomarkers |
| spellingShingle | Mahmoud M. Elgari Omar F. Khabour Samaher M. Alhag Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns Clinical and Experimental Hypertension hypertension preeclampsia cord blood pregnancy biomarkers |
| title | Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns |
| title_full | Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns |
| title_fullStr | Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns |
| title_full_unstemmed | Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns |
| title_short | Correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns |
| title_sort | correlations between changes in hematological indices of mothers with preeclampsia and umbilical cord blood of newborns |
| topic | hypertension preeclampsia cord blood pregnancy biomarkers |
| url | http://dx.doi.org/10.1080/10641963.2018.1441861 |
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