Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer
Abstract Prostate cancer remains the second‐most common cancer diagnosed in men, despite the increasingly widespread use of serum prostate‐specific antigen (PSA) screening. The controversial clinical implications and cost benefits of PSA screening have been highlighted due to its poor specificity, r...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2023-02-01
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| Series: | Smart Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/SMMD.20220020 |
| _version_ | 1797796702963367936 |
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| author | Caizhi Liao Zhihao Wu Chan Lin Xiaofeng Chen Yaqun Zou Wan Zhao Xin Li Guangqi Huang Baisheng Xu Giovanni E. Briganti Yan Qi Xianshu Wang Tao Zeng Alain Wuethrich Hongzhi Zou |
| author_facet | Caizhi Liao Zhihao Wu Chan Lin Xiaofeng Chen Yaqun Zou Wan Zhao Xin Li Guangqi Huang Baisheng Xu Giovanni E. Briganti Yan Qi Xianshu Wang Tao Zeng Alain Wuethrich Hongzhi Zou |
| author_sort | Caizhi Liao |
| collection | DOAJ |
| description | Abstract Prostate cancer remains the second‐most common cancer diagnosed in men, despite the increasingly widespread use of serum prostate‐specific antigen (PSA) screening. The controversial clinical implications and cost benefits of PSA screening have been highlighted due to its poor specificity, resulting in a high rate of overdiagnosis and underdiagnosis. Thus, the development of novel biomarkers for prostate cancer detection remains an intriguing challenge. Urine is emerging as a source for prostate cancer biomarker discovery. Currently, new urine biomarkers already outperform serum PSA in clinical diagnosis. Meanwhile, the advances in nanotechnology have provided a suite of diagnostic tools to study prostate cancer in more detail, sparking a new era of biomarker discoveries. In this review, we envision that future prostate cancer diagnosis will probably integrate multiplex nano‐diagnostic approaches to detect novel urinary biomarkers. However, challenges remain in differentiating indolent from aggressive cancers to better inform treatment decisions, and clinical translation still needs to be overcome. |
| first_indexed | 2024-03-13T03:37:02Z |
| format | Article |
| id | doaj.art-062578dc704843b582ae2596f5747a71 |
| institution | Directory Open Access Journal |
| issn | 2751-1871 |
| language | English |
| last_indexed | 2024-03-13T03:37:02Z |
| publishDate | 2023-02-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Smart Medicine |
| spelling | doaj.art-062578dc704843b582ae2596f5747a712023-06-23T15:10:25ZengWiley-VCHSmart Medicine2751-18712023-02-0121n/an/a10.1002/SMMD.20220020Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancerCaizhi Liao0Zhihao Wu1Chan Lin2Xiaofeng Chen3Yaqun Zou4Wan Zhao5Xin Li6Guangqi Huang7Baisheng Xu8Giovanni E. Briganti9Yan Qi10Xianshu Wang11Tao Zeng12Alain Wuethrich13Hongzhi Zou14Creative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaCreative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaCreative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaSchool of Environmental and Geographical Sciences Shanghai Normal University Shanghai ChinaCreative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaCreative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaDepartment of Urology Sir Run Run Shaw Hospital Zhejiang University Hangzhou ChinaPeking University Health Science Center Beijing ChinaDepartment of Urology The First People's Hospital of Xiushui Jiujiang ChinaDepartment of Urology University of Florence Florence ItalyCreative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaCreative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaDepartment of Urology the Second Affiliated Hospital of Nanchang University Nanchang ChinaCentre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland Brisbane Queensland AustraliaCreative Biosciences (Guangzhou) Co., Ltd Guangzhou ChinaAbstract Prostate cancer remains the second‐most common cancer diagnosed in men, despite the increasingly widespread use of serum prostate‐specific antigen (PSA) screening. The controversial clinical implications and cost benefits of PSA screening have been highlighted due to its poor specificity, resulting in a high rate of overdiagnosis and underdiagnosis. Thus, the development of novel biomarkers for prostate cancer detection remains an intriguing challenge. Urine is emerging as a source for prostate cancer biomarker discovery. Currently, new urine biomarkers already outperform serum PSA in clinical diagnosis. Meanwhile, the advances in nanotechnology have provided a suite of diagnostic tools to study prostate cancer in more detail, sparking a new era of biomarker discoveries. In this review, we envision that future prostate cancer diagnosis will probably integrate multiplex nano‐diagnostic approaches to detect novel urinary biomarkers. However, challenges remain in differentiating indolent from aggressive cancers to better inform treatment decisions, and clinical translation still needs to be overcome.https://doi.org/10.1002/SMMD.20220020nano diagnosticsnanomaterialprostate cancer (PCa)urinary biomarkerurinary liquid biopsy |
| spellingShingle | Caizhi Liao Zhihao Wu Chan Lin Xiaofeng Chen Yaqun Zou Wan Zhao Xin Li Guangqi Huang Baisheng Xu Giovanni E. Briganti Yan Qi Xianshu Wang Tao Zeng Alain Wuethrich Hongzhi Zou Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer Smart Medicine nano diagnostics nanomaterial prostate cancer (PCa) urinary biomarker urinary liquid biopsy |
| title | Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer |
| title_full | Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer |
| title_fullStr | Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer |
| title_full_unstemmed | Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer |
| title_short | Nurturing the marriages of urinary liquid biopsies and nano‐diagnostics for precision urinalysis of prostate cancer |
| title_sort | nurturing the marriages of urinary liquid biopsies and nano diagnostics for precision urinalysis of prostate cancer |
| topic | nano diagnostics nanomaterial prostate cancer (PCa) urinary biomarker urinary liquid biopsy |
| url | https://doi.org/10.1002/SMMD.20220020 |
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