The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex

The RNA-Binding Protein HuD Regulates Alternative Splicing and Alternative Polyadenylation in the Mouse Neocortex

The neuronal Hu/ELAV-like proteins HuB, HuC and HuD are a class of RNA-binding proteins that are crucial for proper development and maintenance of the nervous system. These proteins bind to AU-rich elements (AREs) in the untranslated regions (3′-UTRs) of target mRNAs regulating mRNA stability, trans...

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Bibliographic Details
Main Authors: Rebecca M. Sena, Jeffery L. Twiss, Amy S. Gardiner, Michela Dell’Orco, David N. Linsenbardt, Nora I. Perrone-Bizzozero
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
HuD
<i>Elavl4</i> KO
alternative splicing
alternative polyadenylation
neocortex
Online Access:https://www.mdpi.com/1420-3049/26/10/2836

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