Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks
Aims: Cardiac manifestations are common in COVID-19, often elevated serum troponin levels or myocardial dysfunction on trans-thoracic echocardiography (TTE) is observed. Both parameters are associated with increased in-hospital mortality. Possibly, subclinical coronary atherosclerosis plays a role,...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
|
| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602223000320 |
| _version_ | 1811154299193917440 |
|---|---|
| author | R.A. Groen M.A. de Graaf J.L. Stöger P.R.M. van Dijkman J.W. Jukema M.J. Schalij J.J.M. Geelhoed M.L. Antoni |
| author_facet | R.A. Groen M.A. de Graaf J.L. Stöger P.R.M. van Dijkman J.W. Jukema M.J. Schalij J.J.M. Geelhoed M.L. Antoni |
| author_sort | R.A. Groen |
| collection | DOAJ |
| description | Aims: Cardiac manifestations are common in COVID-19, often elevated serum troponin levels or myocardial dysfunction on trans-thoracic echocardiography (TTE) is observed. Both parameters are associated with increased in-hospital mortality. Possibly, subclinical coronary atherosclerosis plays a role, of which severity can be assessed by calculating the coronary artery calcium (CAC) score. This study aims to determine the relation between coronary atherosclerosis and cardiac manifestations in COVID-19 survivors. Methods: This study was conducted at the Leiden University Medical Center. All patients admitted for COVID-19 were included and scheduled for a 6-week follow-up visit with trans-thoracic echocardiography (TTE). CAC was assessed according to an ordinal score on non-gated, non-contrast enhanced computed tomography of the chest. Patients with and without CAC were compared on cardiac injury as reflected by elevated serum troponin levels and impaired cardiac function assessed through TTE. Results: In total, 146 patients were included. Mean age was 62 years and 62 % of the patients were male. During admission, patients with CAC showed significantly higher levels of troponin (19 ng/L vs 10 ng/L; p < 0.01). Overall, mild echocardiographic abnormalities were seen; 12 % showed reduced left ventricular function (left ventricular ejection fraction of <50 %) and 14 % reduced right ventricular function (tricuspid annular planar systolic excursion ≤17 mm). Following multivariable adjustments, there was no significant relation between CAC and myocardial function at 6 weeks. Conclusion: The present study shows that coronary atherosclerosis is associated with cardiac injury in COVID-19 survivors. However, no significant relation with impaired cardiac function was demonstrated. |
| first_indexed | 2024-04-10T04:14:28Z |
| format | Article |
| id | doaj.art-06274a47a6ee4f008a05a5e7178813ae |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-10T04:14:28Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-06274a47a6ee4f008a05a5e7178813ae2023-03-12T04:22:23ZengElsevierAmerican Heart Journal Plus2666-60222023-03-0127100280Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeksR.A. Groen0M.A. de Graaf1J.L. Stöger2P.R.M. van Dijkman3J.W. Jukema4M.J. Schalij5J.J.M. Geelhoed6M.L. Antoni7Leiden University Medical Centre, Department of Cardiology, Albinusdreef 2, 2333ZA Leiden, the NetherlandsLeiden University Medical Centre, Department of Cardiology, Albinusdreef 2, 2333ZA Leiden, the NetherlandsLeiden University Medical Centre, Department of Radiology, Albinusdreef 2, 2333ZA Leiden, the NetherlandsLeiden University Medical Centre, Department of Cardiology, Albinusdreef 2, 2333ZA Leiden, the NetherlandsLeiden University Medical Centre, Department of Cardiology, Albinusdreef 2, 2333ZA Leiden, the Netherlands; The Netherlands Heart Institute, Moreelsepark 1, 3511 EP Utrecht, The NetherlandsLeiden University Medical Centre, Department of Cardiology, Albinusdreef 2, 2333ZA Leiden, the NetherlandsLeiden University Medical Centre, Department of Pulmonology, Albinusdreef 2, 2333ZA Leiden, the NetherlandsLeiden University Medical Centre, Department of Cardiology, Albinusdreef 2, 2333ZA Leiden, the Netherlands; Corresponding author.Aims: Cardiac manifestations are common in COVID-19, often elevated serum troponin levels or myocardial dysfunction on trans-thoracic echocardiography (TTE) is observed. Both parameters are associated with increased in-hospital mortality. Possibly, subclinical coronary atherosclerosis plays a role, of which severity can be assessed by calculating the coronary artery calcium (CAC) score. This study aims to determine the relation between coronary atherosclerosis and cardiac manifestations in COVID-19 survivors. Methods: This study was conducted at the Leiden University Medical Center. All patients admitted for COVID-19 were included and scheduled for a 6-week follow-up visit with trans-thoracic echocardiography (TTE). CAC was assessed according to an ordinal score on non-gated, non-contrast enhanced computed tomography of the chest. Patients with and without CAC were compared on cardiac injury as reflected by elevated serum troponin levels and impaired cardiac function assessed through TTE. Results: In total, 146 patients were included. Mean age was 62 years and 62 % of the patients were male. During admission, patients with CAC showed significantly higher levels of troponin (19 ng/L vs 10 ng/L; p < 0.01). Overall, mild echocardiographic abnormalities were seen; 12 % showed reduced left ventricular function (left ventricular ejection fraction of <50 %) and 14 % reduced right ventricular function (tricuspid annular planar systolic excursion ≤17 mm). Following multivariable adjustments, there was no significant relation between CAC and myocardial function at 6 weeks. Conclusion: The present study shows that coronary atherosclerosis is associated with cardiac injury in COVID-19 survivors. However, no significant relation with impaired cardiac function was demonstrated.http://www.sciencedirect.com/science/article/pii/S2666602223000320COVID-19Out-patient clinicEchocardiographyCoronary artery calcium |
| spellingShingle | R.A. Groen M.A. de Graaf J.L. Stöger P.R.M. van Dijkman J.W. Jukema M.J. Schalij J.J.M. Geelhoed M.L. Antoni Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks American Heart Journal Plus COVID-19 Out-patient clinic Echocardiography Coronary artery calcium |
| title | Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks |
| title_full | Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks |
| title_fullStr | Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks |
| title_full_unstemmed | Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks |
| title_short | Coronary calcium score in COVID-19 survivors: Association with cardiac injury and cardiac function after 6 weeks |
| title_sort | coronary calcium score in covid 19 survivors association with cardiac injury and cardiac function after 6 weeks |
| topic | COVID-19 Out-patient clinic Echocardiography Coronary artery calcium |
| url | http://www.sciencedirect.com/science/article/pii/S2666602223000320 |
| work_keys_str_mv | AT ragroen coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks AT madegraaf coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks AT jlstoger coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks AT prmvandijkman coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks AT jwjukema coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks AT mjschalij coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks AT jjmgeelhoed coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks AT mlantoni coronarycalciumscoreincovid19survivorsassociationwithcardiacinjuryandcardiacfunctionafter6weeks |