Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

Statin Treatment as a Targeted Therapy for APC-Mutated Colorectal Cancer

BackgroundMutations in the tumor suppressor gene Adenomatous Polyposis Coli (APC) are found in 80% of sporadic colorectal cancer (CRC) tumors and are also responsible for the inherited form of CRC, Familial adenomatous polyposis (FAP).MethodsTo identify novel therapeutic strategies for the treatment...

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Bibliographic Details
Main Authors: Hannah Shailes, Wai Yiu Tse, Marta O. Freitas, Andrew Silver, Sarah A. Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
colorectal (colon) cancer
APC
synthetic lethality
personalized medicine
statin (HMG-CoA reductase inhibitor)
biomarker
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.880552/full

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