Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses

Multivalent DNA Vaccines as a Strategy to Combat Multiple Concurrent Epidemics: Mosquito-Borne and Hemorrhagic Fever Viruses

The emergence of multiple concurrent infectious diseases localized in the world creates a complex burden on global public health systems. Outbreaks of Ebola, Lassa, and Marburg viruses in overlapping regions of central and West Africa and the co-circulation of Zika, Dengue, and Chikungunya viruses i...

Full description

Bibliographic Details
Main Authors:	Jingjing Jiang, Stephanie J. Ramos, Preeti Bangalore, Dustin Elwood, Kathleen A. Cashman, Sagar B. Kudchodkar, Katherine Schultheis, Holly Pugh, Jewell Walters, Jared Tur, Jian Yan, Ami Patel, Kar Muthumani, Connie S. Schmaljohn, David B. Weiner, Laurent M. Humeau, Kate E. Broderick
Format:	Article
Language:	English
Published:	MDPI AG 2021-02-01
Series:	Viruses
Subjects:	DNA vaccine multivalent vaccine platform immunogenicity in vivo electroporation Ebola Lassa
Online Access:	https://www.mdpi.com/1999-4915/13/3/382

Similar Items

Immunogenicity of a protective intradermal DNA vaccine against lassa virus in cynomolgus macaques
by: Jingjing Jiang, et al.
Published: (2019-09-01)

A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever
by: Kathleen A. Cashman, et al.
Published: (2017-12-01)

Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal Electroporation
by: Niranjan Y. Sardesai, et al.
Published: (2013-07-01)

DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs
by: Kathleen A. Cashman, et al.
Published: (2017-12-01)

Hand-Foot-and-Mouth Disease-Associated Enterovirus and the Development of Multivalent HFMD Vaccines
by: Xinglong Zhang, et al.
Published: (2022-12-01)

Evaluating Temperature Sensitivity of Vesicular Stomatitis Virus–Based Vaccines
by: Derek R. Stein, et al.
Published: (2019-08-01)

Elicitation of immune responses against Nipah virus by an engineered synthetic DNA vaccine
by: Hyeree Choi, et al.
Published: (2022-11-01)

Immunogenic Properties of Sonicated Multivalent Antigen of Pseudomonas Aeruginosa
by: Sanam Rezaei Benam, et al.
Published: (2018-01-01)

Analysis of Determinants in Filovirus Glycoproteins Required for Tetherin Antagonism
by: Kerstin Gnirß, et al.
Published: (2014-04-01)

Broad and Effective Protection against <named-content content-type="genus-species">Staphylococcus aureus</named-content> Is Elicited by a Multivalent Vaccine Formulated with Novel Antigens
by: Jian Deng, et al.
Published: (2019-10-01)

Synthetic multivalent molecules : concepts and biomedical applications /
by: Choi, Seok-ki, 1964-
Published: (2004)

Vaccines against Ebola virus and Marburg virus: recent advances and promising candidates
by: John J. Suschak, et al.
Published: (2019-10-01)

Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-delivered Genetic Adjuvants
by: Seleeke eFlingai, et al.
Published: (2013-11-01)

Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification
by: Zhi-Hua Huang, et al.
Published: (2014-07-01)

Assessment of the immune interference effects of multivalent vaccine for influenza epidemic strain in 2022–2023 and evaluation of its efficacy
by: Eulhae Ga, et al.
Published: (2024-03-01)

Synthetic self‐adjuvanted multivalent Mucin 1 (MUC1) glycopeptide vaccines with improved in vivo antitumor efficacy
by: Yang Zhou, et al.
Published: (2024-02-01)

Multivalent glycosystems for nanoscience
by: Thisbe K. Lindhorst
Published: (2014-10-01)

Construction and Immunological Evaluation of an Adenoviral Vector-Based Vaccine Candidate for Lassa Fever
by: Meirong Wang, et al.
Published: (2021-03-01)

Inter-Lineage Variation of Lassa Virus Glycoprotein Epitopes: A Challenge to Lassa Virus Vaccine Development
by: Francis Ifedayo Ibukun
Published: (2020-03-01)

Combinatorial peptide-based epitope mapping from Ebola virus DNA vaccines and infections reveals residue-level determinants of antibody binding
by: Daniel R. Ripoll, et al.
Published: (2017-12-01)

Development of a multivalent adjuvanted inactivated vaccine against variant arthrotropic avian reoviruses
by: Lisanework E. Ayalew, et al.
Published: (2023-10-01)

Immunogenicity Evaluating of the Multivalent COVID-19 Inactivated Vaccine against the SARS-CoV-2 Variants
by: Yuntao Zhang, et al.
Published: (2022-06-01)

Multivalent vaccines demonstrate immunogenicity and protect against Coxiella burnetii aerosol challenge
by: Sharon Jan, et al.
Published: (2023-07-01)

Immunoinformatics design of multivalent epitope vaccine against monkeypox virus and its variants using membrane-bound, enveloped, and extracellular proteins as targets
by: Muhammad Waqas, et al.
Published: (2023-01-01)

Lassa virus: characterization of infectious agent, biological models for pathogenesis studies and variants of vaccine
by: E. I. Kazachinskaya, et al.
Published: (2021-03-01)

Immunization with a Multivalent <i>Listeria monocytogenes</i> Vaccine Leads to a Strong Reduction in Vertical Transmission and Cerebral Parasite Burden in Pregnant and Non-Pregnant Mice Infected with <i>Neospora caninum</i>
by: Dennis Imhof, et al.
Published: (2023-01-01)

Ebola vaccine 2014: remained problems to be answered
by: Somsri Wiwanitkit, et al.
Published: (2015-02-01)

Multivalency as a chemical organization and action principle
by: Rainer Haag
Published: (2015-05-01)

Oral Immunization with a Multivalent Epitope-Based Vaccine, Based on NAP, Urease, HSP60, and HpaA, Provides Therapeutic Effect on H. pylori Infection in Mongolian gerbils
by: Le Guo, et al.
Published: (2017-08-01)

Ebola outbreak in Guinea, 2021: Clinical care of patients with Ebola virus disease
by: Boyo C. Pare, et al.
Published: (2023-01-01)

La Fièvre Hémorragique à Virus Lassa au Bénin en 2014 en contexte d’Ebola : une épidémie révélatrice de la faiblesse du système sanitaire
by: Emmanuel N’koué Sambiéni, et al.

Different Types of Vaccines against Pestiviral Infections: “Barriers” for “<i>Pestis</i>”
by: Mengqi Yuan, et al.
Published: (2022-12-01)

Pregnancy Outcomes among Women Receiving rVSVΔ-ZEBOV-GP Ebola Vaccine during the Sierra Leone Trial to Introduce a Vaccine against Ebola
by: Jennifer K. Legardy-Williams, et al.
Published: (2020-03-01)

Multivalent scaffolds induce galectin-3 aggregation into nanoparticles
by: Candace K. Goodman, et al.
Published: (2014-07-01)

A Multivalent Vaccine Containing Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae Antigens Elicits Strong Immune Responses and Promising Protection in Pigs
by: Hoai Thu Dao, et al.
Published: (2021-03-01)

Intradermal DNA vaccine delivery using vacuum-controlled, needle-free electroporation
by: Alison Generotti, et al.
Published: (2023-12-01)

Immune-Mediated Systemic Vasculitis as the Proposed Cause of Sudden-Onset Sensorineural Hearing Loss following Lassa Virus Exposure in Cynomolgus Macaques
by: Kathleen A. Cashman, et al.
Published: (2018-11-01)

Effects of Shock and Vibration on Product Quality during Last-Mile Transportation of Ebola Vaccine under Refrigerated Conditions
by: Linda Bus-Jacobs, et al.
Published: (2024-04-01)

Ebola vaccine uptake and attitudes among healthcare workers in North Kivu, Democratic Republic of the Congo, 2021
by: Reena H. Doshi, et al.
Published: (2023-07-01)

Comparison of the Efficacy of Different Schemes for Using Recombinant Vector Vaccines against Ebola Fever, Based on Vaccinia Virus, MVA Strain
by: L. F. Stovba, et al.
Published: (2024-01-01)